Title:
TETRAHYDROPROTOBERBERINE COMPOUNDS, THEIR MANUFACTURE, MEDICINAL COMPOSITION AND USES.
Document Type and Number:
WIPO Patent Application WO/2008/014661
Kind Code:
A1
Abstract:
The present invention affords tetrahydroprotoberberine compounds listed as
formula (I) and their pharmaceutically acceptable inorganic or organic salts, crystallized
hydrates, solvates and medicinal compositions. In the formula (I), R1,
R2, R3 and R4 represent H, lined or branched chain
C1-4 alkyl, cyclopropyl, cyclopropyl methyl, methoxyl methyl, methoxycarbonylmethyl,
aryl, benzyl, allyl, or substituted aryl or benzyl. R5 and R6
represent H, halogen, OH, SH, NO2, NH2, substituted or non-substituted
lined or branched C1-4 alkyl. The configuration of C-14 is R, S or its
racemate. The present invention also provides their preparation process and
application in preparing medicine for treating neurological diseases, especially
dopamine receptor related neurological diseases.
Inventors:
YANG YUSHE (CN)
DING YU (CN)
SUN PEIHUA (CN)
MO JIAO (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
ZHEN XUECHU (CN)
DING YU (CN)
SUN PEIHUA (CN)
MO JIAO (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
ZHEN XUECHU (CN)
Application Number:
PCT/CN2007/001734
Publication Date:
February 07, 2008
Filing Date:
May 29, 2007
Export Citation:
Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
YANG YUSHE (CN)
DING YU (CN)
SUN PEIHUA (CN)
MO JIAO (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
ZHEN XUECHU (CN)
YANG YUSHE (CN)
DING YU (CN)
SUN PEIHUA (CN)
MO JIAO (CN)
JIN GUOZHANG (CN)
JI RUYUN (CN)
ZHEN XUECHU (CN)
International Classes:
C07D455/03; A61K31/4375; A61P25/00; A61P25/18
Foreign References:
| CN1115318A | 1996-01-24 | |||
| CN1603324A | 2005-04-06 | |||
| CN1900076A | 2007-01-24 | |||
| CN1900075A | 2007-01-24 |
Other References:
DATABASE CHEM ABS [online] 1977, CHIANG H-C. ET AL.: "An efficient synthesis of 9,10-substituted protoberberine alkaloid:(+-)-stepholidine", Database accession no. (88:89910)
DATABASE CHEM ABS [online] 1977, RAJESWARI S. ET AL.: "Studies in protoberberine alkaloids. VIII. Synthesis of (+-)-stepholidine", Database accession no. (87:201844)
DATABASE CHEM ABS [online] 1977, CHIANG H-C ET AL.: "Total synthesis of (+-)-discretamine and (+-)-stepholidine", Database accession no. (87:152440)
DATABASE CHEM ABS [online] 1984, MCMURTREY K.D. ET AL.: "Kinetics and product distribution in Pictet-Spengler cyclization of tetrahydropapaveroline to tetrahydroprotoberberine alkaloids", Database accession no. (100:139420)
DATABASE CHEM ABS [online] 1989, XU S. ET AL.: "Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain", Database accession no. (110:205069)
DATABASE CHEM ABS [online] 1976, TEITEL S. ET AL.: "Preferential removal of a methylenedioxy group from optically active isoquinolines", Database accession no. (86:43874)
JIN GUOZHANG ET AL: "New chemical dopamine receptor retarder in the brain-tetrahydroprotoberberine", CHINA SCIENCE, vol. B, no. 10, 1985, pages 925 - 930
JIN GUOZHANG ET AL: "New pharmacological effects of tetrahydroprotoberberines on dopamine receptor", CHINA SCIENCE FUND, no. 5, 2000, pages 300 - 304
DATABASE CHEM ABS [online] 1977, RAJESWARI S. ET AL.: "Studies in protoberberine alkaloids. VIII. Synthesis of (+-)-stepholidine", Database accession no. (87:201844)
DATABASE CHEM ABS [online] 1977, CHIANG H-C ET AL.: "Total synthesis of (+-)-discretamine and (+-)-stepholidine", Database accession no. (87:152440)
DATABASE CHEM ABS [online] 1984, MCMURTREY K.D. ET AL.: "Kinetics and product distribution in Pictet-Spengler cyclization of tetrahydropapaveroline to tetrahydroprotoberberine alkaloids", Database accession no. (100:139420)
DATABASE CHEM ABS [online] 1989, XU S. ET AL.: "Effects of tetrahydroprotoberberines on dopamine receptor subtypes in brain", Database accession no. (110:205069)
DATABASE CHEM ABS [online] 1976, TEITEL S. ET AL.: "Preferential removal of a methylenedioxy group from optically active isoquinolines", Database accession no. (86:43874)
JIN GUOZHANG ET AL: "New chemical dopamine receptor retarder in the brain-tetrahydroprotoberberine", CHINA SCIENCE, vol. B, no. 10, 1985, pages 925 - 930
JIN GUOZHANG ET AL: "New pharmacological effects of tetrahydroprotoberberines on dopamine receptor", CHINA SCIENCE FUND, no. 5, 2000, pages 300 - 304
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B Kingsound International Center, 116 Zizhuyuan Road, Haidian District, Beijing 7, CN)
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