Title:
TETRAHYDROTHIENOPYRIDINE DEUTERATED DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/202383
Kind Code:
A1
Abstract:
Disclosed in the present invention are a tetrahydrothienopyridine deuterated derivative, a preparation method therefor, and pharmaceutical use thereof. The derivative can be used for preparing a medicament for the prevention or treatment of a thrombus-related disease. The derivative can balance and optimize the safety and effectiveness of the medicament, and avoid the rapid hydrolysis of the thienopyridine derivative in the gastrointestinal tract, thereby achieving a better therapeutic effect without increasing the risk of bleeding in a patient.
Inventors:
GU JINGKAI (CN)
SUN DONG (CN)
LIU YINGZE (CN)
XU ZHIPING (CN)
ZHANG YUYAO (CN)
LI HAIPENG (CN)
SUN DONG (CN)
LIU YINGZE (CN)
XU ZHIPING (CN)
ZHANG YUYAO (CN)
LI HAIPENG (CN)
Application Number:
PCT/CN2023/086546
Publication Date:
October 26, 2023
Filing Date:
April 06, 2023
Export Citation:
Assignee:
ZHONGRONG KAITE BEIJING BIOTECHNOLOGY CO LTD (CN)
International Classes:
A61K31/4365; C07D495/04; A61K31/4545; A61K31/496; A61K31/551; A61P7/02; A61P9/00; A61P9/10; C07D519/00
Domestic Patent References:
| WO2022028347A1 | 2022-02-10 |
Foreign References:
| CN114736215A | 2022-07-12 | |||
| CN103554132A | 2014-02-05 | |||
| CN107304215A | 2017-10-31 | |||
| CN106467546A | 2017-03-01 | |||
| CN113350338A | 2021-09-07 |
Other References:
XUEYU XU, XUE ZHAO, ZHICHAO YANG, HAO WANG, XIANGJUN MENG, CHONG SU, MINGYUAN LIU, JOHN FAWCETT, YAN YANG, JINGKAI GU: "Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration", MOLECULES, SPRINGER VERLAG, BERLIN, DE, vol. 21, no. 6, 1 June 2016 (2016-06-01), DE , pages 704, XP055768003, ISSN: 1433-1373, DOI: 10.3390/molecules21060704
ZHIPING XU ET AL.: "Study on antiplatelet effect of a new thiophenopyridine platelets P2Y12 receptor antagonist DV-127", THROMBOSIS RESEARCH, no. 170, 1 September 2018 (2018-09-01), XP085495759, ISSN: 0049-3848, DOI: 10.1016/j.thromres.2018.08.022
ZHIPING XU ET AL.: "Study on antiplatelet effect of a new thiophenopyridine platelets P2Y12 receptor antagonist DV-127", THROMBOSIS RESEARCH, no. 170, 1 September 2018 (2018-09-01), XP085495759, ISSN: 0049-3848, DOI: 10.1016/j.thromres.2018.08.022
Attorney, Agent or Firm:
ZJLH INTELLECTUAL PR0PERTY LAW FIRM (GENERAL PARTNER) et al. (CN)
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