Title:
TETRAVALENT PLATINUM COMPLEX AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2013/011858
Kind Code:
A1
Abstract:
[Problem] To provide a novel tetravalent platinum complex characterized by having a high anti-tumor activity on malignant tumors and has relatively reduced adverse side effects.
[Solution] A tetravalent platinum dichloromalonic acid salt complex characterized by having cis, cis-spiro[4,4]nonane-1,6-diamine or an optical active diamine thereof, particularly (S,S,S)-cis, cis-spiro[4,4]nonane-1,6-diamine represented by formula (G), as a ligand.
Inventors:
ARAI HISAE (JP)
KONDO HISAO (JP)
MASUDA NORIO (JP)
KONDO HISAO (JP)
MASUDA NORIO (JP)
Application Number:
PCT/JP2012/067471
Publication Date:
January 24, 2013
Filing Date:
July 09, 2012
Export Citation:
Assignee:
UNITECH CO LTD (JP)
ARAI HISAE (JP)
KONDO HISAO (JP)
MASUDA NORIO (JP)
ARAI HISAE (JP)
KONDO HISAO (JP)
MASUDA NORIO (JP)
International Classes:
C07C211/38; A61K31/282; A61P35/00; C07C55/08; C07F15/00
Domestic Patent References:
| WO2010026711A1 | 2010-03-11 | |||
| WO2010082503A1 | 2010-07-22 | |||
| WO2005007662A2 | 2005-01-27 |
Foreign References:
| JPH02108693A | 1990-04-20 | |||
| JP4664424B2 | 2011-04-06 | |||
| US4140707A | 1979-02-20 | |||
| JP2008225698A | 2008-09-25 | |||
| JP2009004077W | 2009-08-25 |
Other References:
NATURE, vol. 222, 1969, pages 385 - 386
CANCER TREAT REVIEWS, vol. 12, 1985, pages 21 - 33
CANCER LETTERS, vol. 27, 1985, pages 135 - 143
J. INORG. BIOCHEM., vol. 61, 1996, pages 291 - 310
J. MED. CHEM., vol. 40, 1997, pages 112 - 116
See also references of EP 2743252A4
CANCER TREAT REVIEWS, vol. 12, 1985, pages 21 - 33
CANCER LETTERS, vol. 27, 1985, pages 135 - 143
J. INORG. BIOCHEM., vol. 61, 1996, pages 291 - 310
J. MED. CHEM., vol. 40, 1997, pages 112 - 116
See also references of EP 2743252A4
Attorney, Agent or Firm:
MORIYA, KAZUO (JP)
Kazuo Moriya (JP)
Kazuo Moriya (JP)
Download PDF:
Claims: