Title:
TGF-BETA THERAPEUTICS FOR AGE DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/251102
Kind Code:
A3
Abstract:
This invention relates to methods, compositions, kits and uses of medicaments for treating or ameliorating the symptoms of age disease in a human or animal, or for treating or ameliorating the symptoms of a viral disease, or for inhibiting or suppressing entry or replication of a virus in a cell, or for suppressing an inflammatory response or a cytokine storm. These purposes can be achieved with formulations of agents for inhibiting or suppressing expression of TGF-β. More particularly, this invention discloses compositions, methods and uses for anti-TGF-β agents, such as antisense oligonucleotides against TGF-β, artemisinin, or a combination thereof, in a regimen for age disease.
Inventors:
TRIEU VUONG (US)
Application Number:
PCT/US2022/030512
Publication Date:
December 29, 2022
Filing Date:
May 23, 2022
Export Citation:
Assignee:
TRIEU VUONG (US)
GMP BIOTECHNOLOGY LTD (US)
GMP BIOTECHNOLOGY LTD (US)
International Classes:
A61K31/513; A61P31/00; A61P37/02; A61K31/711
Domestic Patent References:
| WO2017138924A1 | 2017-08-17 |
Other References:
TRIEU VUONG, SAUND SARAN, RAHATE PRASHANT V., BARGE VILJAY B., NALK K. SUNIL, WINDLASS HITESH, UCKUN FATIH M.: "Targeting TGF-β pathway with COVID-19 Drug Candidate ARTIVeda/PulmoHeal Accelerates Recovery from Mild-Moderate COVID-19", MEDRXIV, 1 February 2021 (2021-02-01), XP093020983, Retrieved from the Internet [retrieved on 20230206], DOI: 10.1101/2021.01.24.21250418
YAMAMOTO VICKY, BOLANOS JOE F., FIALLOS JOHN, STRAND SUSANNE E., MORRIS KEVIN, SHAHROKHINIA SANAM, CUSHING TIM R., HOPP LAWRENCE, : "COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications", JOURNAL OF ALZHEIMER`S DISEASE, IOS PRESS, NL, vol. 77, no. 2, 15 September 2020 (2020-09-15), NL , pages 459 - 504, XP093020984, ISSN: 1387-2877, DOI: 10.3233/JAD-200831
WEISBERG ELLEN; PARENT ALEXANDER; YANG PRISCILLA L.; SATTLER MARTIN; LIU QINGSONG; LIU QINGWANG; WANG JINHUA; MENG CHENGCHENG; BUH: "Repurposing of Kinase Inhibitors for Treatment of COVID-19", PHARMACEUTICAL RESEARCH, SPRINGER US, NEW YORK, vol. 37, no. 9, 10 August 2020 (2020-08-10), New York, XP037215005, ISSN: 0724-8741, DOI: 10.1007/s11095-020-02851-7
YAMAMOTO VICKY, BOLANOS JOE F., FIALLOS JOHN, STRAND SUSANNE E., MORRIS KEVIN, SHAHROKHINIA SANAM, CUSHING TIM R., HOPP LAWRENCE, : "COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications", JOURNAL OF ALZHEIMER`S DISEASE, IOS PRESS, NL, vol. 77, no. 2, 15 September 2020 (2020-09-15), NL , pages 459 - 504, XP093020984, ISSN: 1387-2877, DOI: 10.3233/JAD-200831
WEISBERG ELLEN; PARENT ALEXANDER; YANG PRISCILLA L.; SATTLER MARTIN; LIU QINGSONG; LIU QINGWANG; WANG JINHUA; MENG CHENGCHENG; BUH: "Repurposing of Kinase Inhibitors for Treatment of COVID-19", PHARMACEUTICAL RESEARCH, SPRINGER US, NEW YORK, vol. 37, no. 9, 10 August 2020 (2020-08-10), New York, XP037215005, ISSN: 0724-8741, DOI: 10.1007/s11095-020-02851-7
Attorney, Agent or Firm:
ECKMAN, Richard R. (US)
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