Title:
THERAPEUTIC AGENT FOR AGITATION
Document Type and Number:
WIPO Patent Application WO/2018/117063
Kind Code:
A1
Abstract:
[Problem] To provide a medicine, in particular, a medicine that is useful for treating agitation.
[Solution] The present inventors conducted intensive studies to provide a therapeutic agent for agitation. As a result, they found that 4-{5-[2-(4-chloro-2,6-difluorophenoxy)propan-2-yl]-4-methyl-4H-1,2,4-triazol-3-yl}-3-fluorobenzamide, which is a 11β-hydroxydehydrogenase type 1 (11β-HSD1) inhibitor, or a salt thereof exhibits an effect of ameliorating agitation. According to the present invention, namely, a medicinal composition comprising 4-{5-[2-(4-chloro-2,6-difluorophenoxy)propan-2-yl]-4-methyl-4H-1,2,4-triazol-3-yl}-3-fluorobenzamide or a salt thereof as an active ingredient is useful for preventing or treating agitation, in particular, agitation associated with Alzheimer's disease.
Inventors:
AKUZAWA SHINOBU (JP)
YARIMIZU JUNKO (JP)
NII KENI (US)
MAREK GERARD (US)
YARIMIZU JUNKO (JP)
NII KENI (US)
MAREK GERARD (US)
Application Number:
PCT/JP2017/045407
Publication Date:
June 28, 2018
Filing Date:
December 19, 2017
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
A61K31/4196; A61P25/28; C07D249/08
Domestic Patent References:
| WO2012033070A1 | 2012-03-15 |
Foreign References:
| JP2016056143A | 2016-04-21 |
Other References:
HATTORI HIDEYUKI: "Aggression and Agitation (Special Feature : Biology of BPSD", JAPANESE JOURNAL OF GERIATRIC PSYCHIATRIY, vol. 16, no. 1, pages 24 - 29, ISSN: 0915-6305
YAU, JOYCE L. W. ET AL.: "Lack of tissue glucocorticoid reactivation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments", PNAS, vol. 98, no. 8, 10 April 2001 (2001-04-10), pages 4716 - 4721, XP002220012, ISSN: 1091-6490, DOI: doi:10.1073/pnas.071562698
YAU, JOYCE L. W. ET AL.: "Lack of tissue glucocorticoid reactivation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice ameliorates age-related learning impairments", PNAS, vol. 98, no. 8, 10 April 2001 (2001-04-10), pages 4716 - 4721, XP002220012, ISSN: 1091-6490, DOI: doi:10.1073/pnas.071562698
Attorney, Agent or Firm:
MORIHIRA, Koichiro et al. (JP)
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