Title:
THERAPEUTIC AGENT FOR AUTOIMMUNE DISEASES
Document Type and Number:
WIPO Patent Application WO/2022/168861
Kind Code:
A1
Abstract:
The present invention provides a polypeptide having an amino acid sequence capable of binding to NRP1 and an amino acid sequence capable of inducing apoptosis.
Inventors:
OKI SHINJI (JP)
YAMAMURA TAKASHI (JP)
RAVENEY BENJAMIN JOSEPH EDWARD (JP)
YAMAMURA TAKASHI (JP)
RAVENEY BENJAMIN JOSEPH EDWARD (JP)
Application Number:
PCT/JP2022/004026
Publication Date:
August 11, 2022
Filing Date:
February 02, 2022
Export Citation:
Assignee:
NAT CENTER NEUROLOGY & PSYCHIATRY (JP)
International Classes:
C07K7/08; A61K38/16; A61K39/395; A61K47/65; A61P37/02; C07K14/435; C07K16/28; C07K19/00; C12N15/13; C12Q1/06; G01N33/53
Domestic Patent References:
| WO2011055550A1 | 2011-05-12 |
Foreign References:
| JP2015172050A | 2015-10-01 | |||
| JP2013504579A | 2013-02-07 | |||
| US20160244835A1 | 2016-08-25 | |||
| KR20190046489A | 2019-05-07 | |||
| JP2018172436A | 2018-11-08 |
Other References:
TEESALU TAMBET; SUGAHARA KAZUKI N; KOTAMRAJU VENKATA RAMANA; RUOSLAHTI ERKKI: "C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 106, no. 38, 22 September 2009 (2009-09-22), pages 16157 - 16162, XP009137580, ISSN: 0027-8424, DOI: 10.1073/pnas.0908201106
Z VADASZ, E TOUBI: "Semaphorin 3A - a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus.", LUPUS, vol. 21, no. 12, 1 October 2012 (2012-10-01), GB , pages 1266 - 1270, XP009538760, ISSN: 0961-2033, DOI: 10.1177/0961203312456753
ALFONSO CATALANO: "The Neuroimmune Semaphorin-3A Reduces Inflammation and Progression of Experimental Autoimmune Arthritis", THE JOURNAL OF IMMUNOLOGY, vol. 185, no. 10, 15 November 2010 (2010-11-15), pages 6373 - 6383, XP055093501, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0903527
Z VADASZ, E TOUBI: "Semaphorin 3A - a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus.", LUPUS, vol. 21, no. 12, 1 October 2012 (2012-10-01), GB , pages 1266 - 1270, XP009538760, ISSN: 0961-2033, DOI: 10.1177/0961203312456753
ALFONSO CATALANO: "The Neuroimmune Semaphorin-3A Reduces Inflammation and Progression of Experimental Autoimmune Arthritis", THE JOURNAL OF IMMUNOLOGY, vol. 185, no. 10, 15 November 2010 (2010-11-15), pages 6373 - 6383, XP055093501, ISSN: 0022-1767, DOI: 10.4049/jimmunol.0903527
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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