Title:
THERAPEUTIC AGENT CONTAINING FUSED PYRIMIDINE COMPOUND AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/125313
Kind Code:
A1
Abstract:
[Problem] To provide a novel therapeutic agent for chronic glomerulonephritis. [Solution] This therapeutic agent for chronic glomerulonephritis contains a compound represented by the following general formula (I) or a salt thereof as an active ingredient.
Inventors:
ARIMA YASUNOBU (JP)
KANEKO RYUSUKE (JP)
KANEKO RYUSUKE (JP)
Application Number:
PCT/JP2020/047370
Publication Date:
June 24, 2021
Filing Date:
December 18, 2020
Export Citation:
Assignee:
TAIHO PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K31/519; A61P13/12; A61P43/00; C07D487/04
Domestic Patent References:
| WO2015022926A1 | 2015-02-19 | |||
| WO2016121953A1 | 2016-08-04 | |||
| WO2016121954A1 | 2016-08-04 | |||
| WO2019043609A1 | 2019-03-07 | |||
| WO2015022926A1 | 2015-02-19 | |||
| WO2016121953A1 | 2016-08-04 | |||
| WO2016121954A1 | 2016-08-04 |
Foreign References:
| JP2017533881A | 2017-11-16 | |||
| JP2019229171A | 2019-12-19 |
Other References:
CHEN JIN-SHUEN, CHANG LI-CHIEN, HUANG SHYH-JER, CHENG CHAO-WEN: "Targeting Spleen Tyrosine Kinase-Bruton’s Tyrosine Kinase Axis for Immunologically Mediated Glomerulonephritis", BIOMED RESEARCH INTERNATIONAL, HINDAWI PUBLISHING CORPORATION, vol. 2014, 1 January 2014 (2014-01-01), pages 1 - 6, XP055836051, ISSN: 2314-6133, DOI: 10.1155/2014/814869
CHALMERS SAMANTHA A., CHALMERS SAMANTHA, DOERNER JESSICA, BOSANAC TODD, KHALIL SARA, SMITH DUSTIN, HARCKEN CHRISTIAN, DIMOCK JANIC: "Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, vol. 6, no. 1, 1 May 2016 (2016-05-01), pages 26164, XP055836052, DOI: 10.1038/srep26164
PRAKASH ET AL., CLIN NEPHROL., vol. 70, no. 5, November 2008 (2008-11-01), pages 377 - 84
LAI ET AL.: "2", NAT REV DIS PRIMERS., 11 February 2016 (2016-02-11), pages 16001
YEO ET AL., PEDIATR NEPHROL., vol. 33, no. 5, May 2018 (2018-05-01), pages 763 - 777
SUZUKI ET AL., CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol. 23, 2019, pages 26 - 31
LIM ET AL., NEPHROLOGY, vol. 8, no. 1, 2003, pages 21 - 7
LAI ET AL., KIDNEY DIS, vol. 1, no. 1, 2015, pages 19 - 26
DONADIO ET AL., N ENGL J MED, vol. 347, 2002, pages 738 - 748
SCHAEFFERSCHWARTZBERG, CURR OP IMM, 2000, pages 282 - 288
SCHMIDT U. ET AL., INT ARCH ALLERGY IMMUNOL, vol. 134, 2004
ELLMEIER W. ET AL., FEBS JOURNAL, vol. 278, 2011
ROMMEL C. ET AL., NATURE REVIEWS IMMUNOLOGY, vol. 7, 2007
CHENGYUAN L. ET AL., EUR J MED, vol. 151, 2018, pages 315 - 326
HIROKAWA SHOTEN: "Iyakuhin no Kaihatsu (Development of Pharmaceutical Products", MOLECULAR DESIGNING, vol. 7, 1990, pages 163 - 198
CASTIGLI ET AL., J ALLERGY CLIN IMMUNOL, vol. 120, no. 4, 2007, pages 885 - 91
CHANG ET AL., ARTHRITIS RES THER, vol. 13, no. 4, 2011, pages R115
MUSO ET AL., KIDNEY INTERNATIONAL, vol. 50, 1996, pages 1946 - 1957
LIU ET AL., RENAL FAILURE, vol. 38, no. 9, 2016, pages 1347 - 1352
See also references of EP 4079306A4
CHALMERS SAMANTHA A., CHALMERS SAMANTHA, DOERNER JESSICA, BOSANAC TODD, KHALIL SARA, SMITH DUSTIN, HARCKEN CHRISTIAN, DIMOCK JANIC: "Therapeutic Blockade of Immune Complex-Mediated Glomerulonephritis by Highly Selective Inhibition of Bruton’s Tyrosine Kinase", SCIENTIFIC REPORTS, NATURE PUBLISHING GROUP, vol. 6, no. 1, 1 May 2016 (2016-05-01), pages 26164, XP055836052, DOI: 10.1038/srep26164
PRAKASH ET AL., CLIN NEPHROL., vol. 70, no. 5, November 2008 (2008-11-01), pages 377 - 84
LAI ET AL.: "2", NAT REV DIS PRIMERS., 11 February 2016 (2016-02-11), pages 16001
YEO ET AL., PEDIATR NEPHROL., vol. 33, no. 5, May 2018 (2018-05-01), pages 763 - 777
SUZUKI ET AL., CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol. 23, 2019, pages 26 - 31
LIM ET AL., NEPHROLOGY, vol. 8, no. 1, 2003, pages 21 - 7
LAI ET AL., KIDNEY DIS, vol. 1, no. 1, 2015, pages 19 - 26
DONADIO ET AL., N ENGL J MED, vol. 347, 2002, pages 738 - 748
SCHAEFFERSCHWARTZBERG, CURR OP IMM, 2000, pages 282 - 288
SCHMIDT U. ET AL., INT ARCH ALLERGY IMMUNOL, vol. 134, 2004
ELLMEIER W. ET AL., FEBS JOURNAL, vol. 278, 2011
ROMMEL C. ET AL., NATURE REVIEWS IMMUNOLOGY, vol. 7, 2007
CHENGYUAN L. ET AL., EUR J MED, vol. 151, 2018, pages 315 - 326
HIROKAWA SHOTEN: "Iyakuhin no Kaihatsu (Development of Pharmaceutical Products", MOLECULAR DESIGNING, vol. 7, 1990, pages 163 - 198
CASTIGLI ET AL., J ALLERGY CLIN IMMUNOL, vol. 120, no. 4, 2007, pages 885 - 91
CHANG ET AL., ARTHRITIS RES THER, vol. 13, no. 4, 2011, pages R115
MUSO ET AL., KIDNEY INTERNATIONAL, vol. 50, 1996, pages 1946 - 1957
LIU ET AL., RENAL FAILURE, vol. 38, no. 9, 2016, pages 1347 - 1352
See also references of EP 4079306A4
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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