Title:
THERAPEUTIC AGENT FOR FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2020/152869
Kind Code:
A1
Abstract:
Disclosed is an antisense nucleic acid that suppresses the expression of an NEK6 gene.
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Inventors:
NAKAO KAZUHISA (JP)
ISHIYAMA JUNICHI (JP)
ICHIKAWA WATARU (JP)
MASUI ATSUSHI (JP)
AKASAKA YUNIKE (JP)
HONDA AYA (JP)
ISHIYAMA JUNICHI (JP)
ICHIKAWA WATARU (JP)
MASUI ATSUSHI (JP)
AKASAKA YUNIKE (JP)
HONDA AYA (JP)
Application Number:
PCT/JP2019/002560
Publication Date:
July 30, 2020
Filing Date:
January 25, 2019
Export Citation:
Assignee:
KYORIN SEIYAKU KK (JP)
International Classes:
A61K31/7105; A61P1/16; A61P11/00; A61P13/12
Domestic Patent References:
| WO2019022257A1 | 2019-01-31 | |||
| WO2012017919A1 | 2012-02-09 | |||
| WO2012005368A1 | 2012-01-12 | |||
| WO2012017919A1 | 2012-02-09 | |||
| WO2013027843A1 | 2013-02-28 | |||
| WO2016159374A1 | 2016-10-06 | |||
| WO2013027843A1 | 2013-02-28 |
Foreign References:
| US20040097441A1 | 2004-05-20 | |||
| US20040097441A1 | 2004-05-20 | |||
| US3687808A | 1972-08-29 |
Other References:
ATISH D. CHOUDHURY, SCHINZEL ANNA C., COTTER MAURA B., LIS ROSINA T., LABELLA KATHERINE, LOCK YING JIE, IZZO FRANCESCA, GUNEY ISIL: "Castration resistance in prostate cancer is mediated by the kinase NEK6", CANCER RESEACH, vol. 77, no. 3, 29 November 2016 (2016-11-29) - 1 February 2017 (2017-02-01), pages 753 - 765, XP055728097, ISSN: 0008-5472
JEE, H. J. ET AL.: "The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment", CANCER LETTERS, vol. 335, no. 1, 2013, pages 175 - 182, XP028551320, ISSN: 0304-3835, DOI: 10.1016/j.canlet.2013.02.012
MARTA DE DONATO, RIGHINO BENEDETTA, FILIPPETTI FLAVIA, BATTAGLIA ALESSANDRA, PETRILLO MARCO, PIROLLI DAVIDE, SCAMBIA GIOVANNI, DE : "Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6", SCIENTIFIC REPORTS, vol. 8, no. 16047, 30 October 2018 (2018-10-30), pages 1 - 13, XP055728118, ISSN: 2045-2322
ZHOUYAN BIAN, LIAO HAIHAN, ZHANG YAN, WU QINGQING, ZHOU HENG, YANG ZHENG, FU JINRONG, WANG TENG, YAN LING, SHEN DIFEI, LI HONGLIAN: "Never in mitosis gene a related kinase-6 attenuates pressure overload-induced activation of the protein kinase b pathway and cardiac hypertrophy", PLOS ONE, vol. 9, no. 4, 14 April 2014 (2014-04-14), pages e96095, XP055728121, ISSN: 1932-6203
ZUO, J. ET AL.: "An inhibitory role of NEK6 in TGFp/Smad signaling pathway", BMB REPORTS, vol. 48, no. 8, 2015831, pages 473 - 478, XP055728131, ISSN: 1976-670X
"GenBank", Database accession no. NM 014397
LIMBACH ET AL.: "Summary: the modified nucleosides of RNA", NUCLEIC ACIDS RES., vol. 22, 1994, pages 2183 - 2196, XP001152667
"Concise Encyclopedia Of Polymer Science And Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL., ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 30, 1991, pages 613
See also references of EP 3915567A4
JEE, H. J. ET AL.: "The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment", CANCER LETTERS, vol. 335, no. 1, 2013, pages 175 - 182, XP028551320, ISSN: 0304-3835, DOI: 10.1016/j.canlet.2013.02.012
MARTA DE DONATO, RIGHINO BENEDETTA, FILIPPETTI FLAVIA, BATTAGLIA ALESSANDRA, PETRILLO MARCO, PIROLLI DAVIDE, SCAMBIA GIOVANNI, DE : "Identification and antitumor activity of a novel inhibitor of the NIMA-related kinase NEK6", SCIENTIFIC REPORTS, vol. 8, no. 16047, 30 October 2018 (2018-10-30), pages 1 - 13, XP055728118, ISSN: 2045-2322
ZHOUYAN BIAN, LIAO HAIHAN, ZHANG YAN, WU QINGQING, ZHOU HENG, YANG ZHENG, FU JINRONG, WANG TENG, YAN LING, SHEN DIFEI, LI HONGLIAN: "Never in mitosis gene a related kinase-6 attenuates pressure overload-induced activation of the protein kinase b pathway and cardiac hypertrophy", PLOS ONE, vol. 9, no. 4, 14 April 2014 (2014-04-14), pages e96095, XP055728121, ISSN: 1932-6203
ZUO, J. ET AL.: "An inhibitory role of NEK6 in TGFp/Smad signaling pathway", BMB REPORTS, vol. 48, no. 8, 2015831, pages 473 - 478, XP055728131, ISSN: 1976-670X
"GenBank", Database accession no. NM 014397
LIMBACH ET AL.: "Summary: the modified nucleosides of RNA", NUCLEIC ACIDS RES., vol. 22, 1994, pages 2183 - 2196, XP001152667
"Concise Encyclopedia Of Polymer Science And Engineering", 1990, JOHN WILEY & SONS, pages: 858 - 859
ENGLISCH ET AL., ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 30, 1991, pages 613
See also references of EP 3915567A4
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
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