Title:
THERAPEUTIC AGENT FOR GAIT DISTURBANCE
Document Type and Number:
WIPO Patent Application WO/2022/211052
Kind Code:
A1
Abstract:
The present invention relates to a therapeutic agent for a gait disturbance of a patient associated with an ischemic disease, the therapeutic agent containing, as an active ingredient, a heterocyclic derivative represented by general formula (1) or a pharmaceutically acceptable salt thereof. In formula (1), R1 and R2, which may be the same or different, each represent aryl that may be substituted; R3 and R4, which may be the same or different, each represent a hydrogen atom or alkyl; R5 represents a hydrogen atom, alkyl or a halogen atom; Y represents N or N→O; A represents NR6 and R6 represents a hydrogen atom, alkyl or the like; D represents alkylene or alkenylene that may be substituted with hydroxy; E represents phenylene or a single bond; G represents O, S, or the like; and Q represents carboxy, alkoxycarbonyl, or the like.
Inventors:
MURAKAMI KOJI (JP)
MINAMI TOSHIYUKI (JP)
MINAMI TOSHIYUKI (JP)
Application Number:
PCT/JP2022/016648
Publication Date:
October 06, 2022
Filing Date:
March 31, 2022
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
A61K31/4965; A61P9/10; A61P19/00; A61P21/00
Domestic Patent References:
| WO2009157396A1 | 2009-12-30 | |||
| WO2002088084A1 | 2002-11-07 | |||
| WO2002088084A1 | 2002-11-07 |
Other References:
TETSURO MIYATA, KOHEI AKAZAWA, MASAHIRO AKISHITA ET AL. : "Guidelines for the management of peripheral occlusive arterial diseases (2015 revised edition)", 2014 JOINT RESEARCH REPORT. DIGEST EDITION, JP, JP, pages 1 - 15-36, XP009543363
ANONYMOUS: "Lumbar spinal canal stenosis", THE JAPANESE ORTHOPAEDIC ASSOCIATION CORPORATION, 2 September 2020 (2020-09-02), XP055971710, Retrieved from the Internet [retrieved on 20221017]
ANONYMOUS: "Lumbar spinal canal stenosis", THE JAPANESE ORTHOPAEDIC ASSOCIATION CORPORATION, 2 September 2020 (2020-09-02), XP055971710, Retrieved from the Internet
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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