Title:
THERAPEUTIC AGENT FOR MENISCUS
Document Type and Number:
WIPO Patent Application WO/2024/005133
Kind Code:
A1
Abstract:
Provided are: a pharmaceutical composition for treating damage to the white-white zone or red-white zone of the meniscus, said composition containing an HMGB1 fragment peptide containing an amino acid sequence delimited by SEQ ID NO 1, or a variant thereof; and a pharmaceutical composition for treating a meniscus excision site, said composition containing an HMGB1 fragment peptide containing an amino acid sequence delimited by SEQ ID NO 1, or a variant thereof.
Inventors:
TAMAI KATSUTO (JP)
SHIMBO TAKASHI (JP)
ISHIBASHI KYOTA (JP)
YAMAZAKI TAKEHIKO (JP)
SHIMBO TAKASHI (JP)
ISHIBASHI KYOTA (JP)
YAMAZAKI TAKEHIKO (JP)
Application Number:
PCT/JP2023/024150
Publication Date:
January 04, 2024
Filing Date:
June 29, 2023
Export Citation:
Assignee:
UNIV OSAKA (JP)
STEMRIM INC (JP)
STEMRIM INC (JP)
International Classes:
A61P19/04; A61K38/16; C07K14/47
Domestic Patent References:
| WO2020085506A1 | 2020-04-30 | |||
| WO2019156137A1 | 2019-08-15 | |||
| WO2014065347A1 | 2014-05-01 |
Foreign References:
| JP6994729B1 | 2022-02-10 | |||
| US20090060971A1 | 2009-03-05 |
Other References:
XU HONGYAO, HUANG HE, ZOU XIANGJIE, XIA PENGCHENG, FOON WARREN A. L. S., WANG JINWEN: "A novel bio-active microsphere for meniscus regeneration via inducing cell migration and chondrocyte differentiation. ", BIO-DESIGN AND MANUFACTURING, vol. 4, no. 2, 1 January 2021 (2021-01-01), pages 203 - 221, XP009552275, ISSN: 2096-5524, DOI: 10.1007/s42242-020-00118-z
KYOTA ISHIBASHI, HIDETSUGU SASAKI, TAKASHI SHINBO, HOMADAI, YOSHI NAKAMURA, YASUYUKI ISHIBASHI, KATSUTO TAMAI: "1-7-38: Therapeutic effect of intravenous administration of regeneration-inducing drug HMGB1 peptide on meniscal damage.", JOURNAL OF THE JAPANESE ORTHOPEDIC SOCIETY, JP, vol. 96, no. 8, 15 September 2022 (2022-09-15), JP, pages S1595, XP009551668, ISSN: 0021-5325
KYOTA ISHIBASHI, HIDETSUGU SASAKI, TAKASHI SHINBO, HOMADAI, YOSHI NAKAMURA, YASUYUKI ISHIBASHI, KATSUTO TAMAI: "1-7-38: Therapeutic effect of intravenous administration of regeneration-inducing drug HMGB1 peptide on meniscal damage.", JOURNAL OF THE JAPANESE ORTHOPEDIC SOCIETY, JP, vol. 96, no. 8, 15 September 2022 (2022-09-15), JP, pages S1595, XP009551668, ISSN: 0021-5325
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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