Title:
THERAPEUTIC AGENT FOR NEUROGENIC PAIN
Document Type and Number:
WIPO Patent Application WO/2007/043365
Kind Code:
A1
Abstract:
Disclosed is a therapeutic agent for neurogenic pain, which has an excellent therapeutic effect on neurogenic pain which is an intractable disease. Specifically, disclosed is a therapeutic agent for neurogenic pain or a pharmaceutical composition for the treatment of neurogenic pain which comprises, as an active ingredient, (1) a compound having an anti-progesterone activity (e.g., fulvestrant (ICI182.780), fluocinolone acetonide, triamcinolone acetonide), (2) a compound having an estrogenic activity (e.g., 17β-estradiol) or (3) a mixture of a compound having an anti-progesterone activity and a compound having an estrogenic activity (e.g., 17β-estradiol and fulvestrant). Also disclosed is a method for treatment of neurogenic pain by using any one of the compounds.
Inventors:
TANABE TSUTOMU (JP)
Application Number:
PCT/JP2006/319637
Publication Date:
April 19, 2007
Filing Date:
September 26, 2006
Export Citation:
Assignee:
JAPAN SCIENCE & TECH AGENCY (JP)
NAT UNIV CORP TOKYO MED & DENT (JP)
TANABE TSUTOMU (JP)
NAT UNIV CORP TOKYO MED & DENT (JP)
TANABE TSUTOMU (JP)
International Classes:
A61K31/05; A61K45/00; A61K31/565; A61K31/566; A61K31/573; A61K31/58; A61P5/30; A61P5/36; A61P25/00; A61P25/02; A61P25/04; A61P43/00
Domestic Patent References:
| WO2002069995A2 | 2002-09-12 | |||
| WO2004089410A1 | 2004-10-21 | |||
| WO2004037199A2 | 2004-05-06 |
Foreign References:
| JPH11509844A | 1999-08-31 | |||
| JPH10511378A | 1998-11-04 | |||
| JP2002505279A | 2002-02-19 | |||
| US4386085A | 1983-05-31 | |||
| JPH10511378A | 1998-11-04 |
Other References:
GOTO H. ET AL: "Taijo Hoshintsu ni Taisuru Triamcinolone Acetonide Komakugai Toyo no Koka", PAIN CLINIC, vol. 9, no. 4, 1988, pages 489 - 494, XP003011714
OKADO H. ET AL: "Taijo Hoshin Shinkeitsu ni Taisuru Shinkeikon Block no Yuyosei", JOURNALOF THE JAPAN SOCIETY OF PAIN CLINICIANS, vol. 12, no. 3, 25 June 2005 (2005-06-25), 1-A-21, pages 241, XP003011715
ITO A. ET AL: "OVX Rat ni Okeru Elcatonin no Koshingai Juyo (Chintsu) Sayo - Estrogen tono Hikaku", OSTEOPOROSIS JAPAN, vol. 10, no. 2, 2002, pages 83 - 85, XP003011716
INAMORI K.: "Taijo Hoshingo Shinkeitsu no Naifuku Ryoho", PAIN CLINIC, vol. 17, no. 4, 1996, pages 533 - 537, XP003011717
WANG S. ET AL: "Expression of Central Glucocorticoid Receptors after Peripheral Nerve Injury Contributes to Neuropathic Pain Behaviors in Rats", JOURNAL OF NEUROSCIENCE, vol. 24, no. 39, 2004, pages 8595 - 8605, XP003011718
OKADA H.: "Shinkei Insei Totsu no Yakubutsu Ryoho to Shinkei Block Ryoho", JOURNAL OF PAIN AND CLINICAL MEDICINE, vol. 3, no. 1, 2003, pages 26 - 32, XP003011719
MORIWAKI K.: "Shinkei Insei Totsu (Neuropathic Pain)", CURRENT THERAPY, vol. 23, no. 8, 25 July 2005 (2005-07-25), XP003011720
TOMINAGA T.: "Sekizui Sonsho no Mahiiki no Itami", SOGO REHABILITATION, vol. 31, no. 5, 2003, pages 411 - 417, XP003011721
NAGAI A. ET AL: "Shishi Setsudango no Genshitsu", SOGO REHABILITATION, vol. 31, no. 5, 2003, pages 431 - 436, XP003011722
J. NEUROSCI, vol. 24, 2004, pages 8595 - 8605
J. NEUROSCI, vol. 25, 2005, pages 488 - 495
CANCER RESEARCH, vol. 59, 1999, pages 372 - 376
MOL. CELL BIOL., vol. 25, 2005, pages 5417 - 5428
See also references of EP 1944041A4
OKADO H. ET AL: "Taijo Hoshin Shinkeitsu ni Taisuru Shinkeikon Block no Yuyosei", JOURNALOF THE JAPAN SOCIETY OF PAIN CLINICIANS, vol. 12, no. 3, 25 June 2005 (2005-06-25), 1-A-21, pages 241, XP003011715
ITO A. ET AL: "OVX Rat ni Okeru Elcatonin no Koshingai Juyo (Chintsu) Sayo - Estrogen tono Hikaku", OSTEOPOROSIS JAPAN, vol. 10, no. 2, 2002, pages 83 - 85, XP003011716
INAMORI K.: "Taijo Hoshingo Shinkeitsu no Naifuku Ryoho", PAIN CLINIC, vol. 17, no. 4, 1996, pages 533 - 537, XP003011717
WANG S. ET AL: "Expression of Central Glucocorticoid Receptors after Peripheral Nerve Injury Contributes to Neuropathic Pain Behaviors in Rats", JOURNAL OF NEUROSCIENCE, vol. 24, no. 39, 2004, pages 8595 - 8605, XP003011718
OKADA H.: "Shinkei Insei Totsu no Yakubutsu Ryoho to Shinkei Block Ryoho", JOURNAL OF PAIN AND CLINICAL MEDICINE, vol. 3, no. 1, 2003, pages 26 - 32, XP003011719
MORIWAKI K.: "Shinkei Insei Totsu (Neuropathic Pain)", CURRENT THERAPY, vol. 23, no. 8, 25 July 2005 (2005-07-25), XP003011720
TOMINAGA T.: "Sekizui Sonsho no Mahiiki no Itami", SOGO REHABILITATION, vol. 31, no. 5, 2003, pages 411 - 417, XP003011721
NAGAI A. ET AL: "Shishi Setsudango no Genshitsu", SOGO REHABILITATION, vol. 31, no. 5, 2003, pages 431 - 436, XP003011722
J. NEUROSCI, vol. 24, 2004, pages 8595 - 8605
J. NEUROSCI, vol. 25, 2005, pages 488 - 495
CANCER RESEARCH, vol. 59, 1999, pages 372 - 376
MOL. CELL BIOL., vol. 25, 2005, pages 5417 - 5428
See also references of EP 1944041A4
Attorney, Agent or Firm:
KOBAYASHI, Hiroshi et al. (IKUBO & KATAYAMA Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-k, Tokyo 28, JP)
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