Title:
THERAPEUTIC AGENT OR PREVENTIVE AGENT FOR DRUG-INDUCED MYOCARDIAL DISORDERS
Document Type and Number:
WIPO Patent Application WO/2023/249105
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a therapeutic agent or a preventive agent for drug-induced myocardial disorders and having ferroptosis inhibitory action. The present invention provides a therapeutic agent or a preventive agent for drug-induced myocardial disorders, comprising, as an active ingredient, a tetrahydroquinoline derivative represented by the following compound, or a pharmacologically acceptable salt thereof.
Inventors:
TAKAHASHI TAKEHIRO (JP)
NARUMI HIDEKI (JP)
OSHIDA KEIYU (JP)
HIRAKATA MIKITO (JP)
TAKAGAKI KOZUE (JP)
MEGURO HIROYUKI (JP)
YAMAMOTO MASASHI (JP)
ASABA KEN NUNETTSU (JP)
NOGAMI MARINA (JP)
TSUJI RIICHIRO (JP)
UKEGAWA NAOYA (JP)
NARUMI HIDEKI (JP)
OSHIDA KEIYU (JP)
HIRAKATA MIKITO (JP)
TAKAGAKI KOZUE (JP)
MEGURO HIROYUKI (JP)
YAMAMOTO MASASHI (JP)
ASABA KEN NUNETTSU (JP)
NOGAMI MARINA (JP)
TSUJI RIICHIRO (JP)
UKEGAWA NAOYA (JP)
Application Number:
PCT/JP2023/023262
Publication Date:
December 28, 2023
Filing Date:
June 23, 2023
Export Citation:
Assignee:
TORAY INDUSTRIES (JP)
International Classes:
A61K31/47; A61K31/4709; A61K31/496; A61K31/5377; A61P9/04; A61P43/00
Domestic Patent References:
| WO2013011930A1 | 2013-01-24 | |||
| WO2019106434A1 | 2019-06-06 | |||
| WO2022138888A1 | 2022-06-30 |
Foreign References:
| JP2022523860A | 2022-04-26 |
Other References:
LIU X., ET AL.: "Highly regio-, diastereo- and enantioselective one-pot gold/chiral Bronsted acid-catalyzed cascade synthesis of bioactive diversely substituted tetrahydroquinolines", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, vol. 10, no. 35, 1 January 2012 (2012-01-01), pages 7208 - 7219, XP055944584, ISSN: 1477-0520, DOI: 10.1039/C2OB25753J
FANG XUEXIAN, WANG HAO, HAN DAN, XIE ENJUN, YANG XIANG, WEI JIAYU, GU SHANSHAN, GAO FENG, ZHU NALI, YIN XIANGJU, CHENG QI, ZHANG P: "Ferroptosis as a target for protection against cardiomyopathy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 7, 12 February 2019 (2019-02-12), pages 2672 - 2680, XP055905845, ISSN: 0027-8424, DOI: 10.1073/pnas.1821022116
TADOKORO TOMONORI, IKEDA MASATAKA, IDE TOMOMI, DEGUCHI HIROKO, IKEDA SOICHIRO, OKABE KOSUKE, ISHIKITA AKIHITO, MATSUSHIMA SHOUJI, : "Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity", JCI INSIGHT, vol. 5, no. 9, 7 May 2020 (2020-05-07), XP093119987, ISSN: 2379-3708, DOI: 10.1172/jci.insight.132747
FANG XUEXIAN, WANG HAO, HAN DAN, XIE ENJUN, YANG XIANG, WEI JIAYU, GU SHANSHAN, GAO FENG, ZHU NALI, YIN XIANGJU, CHENG QI, ZHANG P: "Ferroptosis as a target for protection against cardiomyopathy", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 7, 12 February 2019 (2019-02-12), pages 2672 - 2680, XP055905845, ISSN: 0027-8424, DOI: 10.1073/pnas.1821022116
TADOKORO TOMONORI, IKEDA MASATAKA, IDE TOMOMI, DEGUCHI HIROKO, IKEDA SOICHIRO, OKABE KOSUKE, ISHIKITA AKIHITO, MATSUSHIMA SHOUJI, : "Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity", JCI INSIGHT, vol. 5, no. 9, 7 May 2020 (2020-05-07), XP093119987, ISSN: 2379-3708, DOI: 10.1172/jci.insight.132747
Attorney, Agent or Firm:
TANIGAWA AND PARTNERS, PATENT FIRM (JP)
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