Title:
THERAPEUTIC AGENT FOR SPINAL CORD INJURY
Document Type and Number:
WIPO Patent Application WO/2023/171808
Kind Code:
A1
Abstract:
[Problem] To provide a therapeutic agent for spinal cord injury, namely, chronic incomplete spinal cord injury or chronic complete spinal cord injury, for which treatment has been conventionally difficult. [Solution] The present invention was accomplished upon confirming that this agent has a spinal injury therapeutic effect, a motor function improvement effect, and a urinary function improvement effect for chronic incomplete spinal cord injury or chronic complete spinal cord injury, the agent comprising: (a) a hepatocyte growth factor; a carrier which carries said (a) and can release said (a) in a sustained manner; and iPS cell-derived neural stem and/or progenitor cells.
Inventors:
HASHIMOTO SHOGO (JP)
NAGOSHI NARIHITO (JP)
NAKAMURA MASAYA (JP)
OKANO HIDEYUKI (JP)
NAGOSHI NARIHITO (JP)
NAKAMURA MASAYA (JP)
OKANO HIDEYUKI (JP)
Application Number:
PCT/JP2023/009421
Publication Date:
September 14, 2023
Filing Date:
March 10, 2023
Export Citation:
Assignee:
UNIV KEIO (JP)
KRINGLE PHARMA INC (JP)
KRINGLE PHARMA INC (JP)
International Classes:
A61K35/12; A61K38/18; A61K47/42; A61P25/28
Domestic Patent References:
| WO2008105507A1 | 2008-09-04 |
Other References:
FUJIYOSHI, KANEHIRO; TSUJI, OSAHIKO: "Development of Spinal Cord Injury Treatment Methods, Initiatives at Murayama Medical Center: Novel Treatment Method HGF for Acute Spinal Cord Injury", IRYO NO HIROBA = MEDICAL AGORA, vol. 60, no. 9, 1 January 2020 (2020-01-01), pages 4 - 6, XP009548883
YAMANE KENTARO, MAZAKI TETSURO, SHIOZAKI YASUYUKI, YOSHIDA AKI, SHINOHARA KENSUKE, NAKAMURA MARIKO, YOSHIDA YASUHIRO, ZHOU DI, KIT: "Collagen-Binding Hepatocyte Growth Factor (HGF) alone or with a Gelatin- furfurylamine Hydrogel Enhances Functional Recovery in Mice after Spinal Cord Injury", SCIENTIFIC REPORTS, vol. 8, no. 1, 17 June 2018 (2018-06-17), pages 917, XP093088992, DOI: 10.1038/s41598-018-19316-y
DRAGAS RACHEL, JAMES HONG, AHAD SIDDIQUI, MICHAEL FEHLINGS: "B28-01 A COMBINATORIAL TREATMENT STRATEGY FOR REDUCING ASTROCYTE REACTIVITY USING NEURAL PROGENITOR CELLS AND HEPATOCYTE GROWTH FACTOR", JOURNAL OF NEUROTRAUMA., M.A. LIEBERT, NEW YORK, NY., US, vol. 34, no. 13, 1 July 2017 (2017-07-01), US , pages A - 147, XP093089240, ISSN: 0897-7151, DOI: 10.1089/neu.2017.29011.abstracts
IWANAMI, AKIO : "Establishment of Neural Stem Cell Transplantation and Hepatocyte Growth Factor Combined Treatment for Spinal Cord Injury", CLINICAL RESEARCH, 1 January 2006 (2006-01-01), pages 9 - 14, XP009553129
YAMANE KENTARO, MAZAKI TETSURO, SHIOZAKI YASUYUKI, YOSHIDA AKI, SHINOHARA KENSUKE, NAKAMURA MARIKO, YOSHIDA YASUHIRO, ZHOU DI, KIT: "Collagen-Binding Hepatocyte Growth Factor (HGF) alone or with a Gelatin- furfurylamine Hydrogel Enhances Functional Recovery in Mice after Spinal Cord Injury", SCIENTIFIC REPORTS, vol. 8, no. 1, 17 June 2018 (2018-06-17), pages 917, XP093088992, DOI: 10.1038/s41598-018-19316-y
DRAGAS RACHEL, JAMES HONG, AHAD SIDDIQUI, MICHAEL FEHLINGS: "B28-01 A COMBINATORIAL TREATMENT STRATEGY FOR REDUCING ASTROCYTE REACTIVITY USING NEURAL PROGENITOR CELLS AND HEPATOCYTE GROWTH FACTOR", JOURNAL OF NEUROTRAUMA., M.A. LIEBERT, NEW YORK, NY., US, vol. 34, no. 13, 1 July 2017 (2017-07-01), US , pages A - 147, XP093089240, ISSN: 0897-7151, DOI: 10.1089/neu.2017.29011.abstracts
IWANAMI, AKIO : "Establishment of Neural Stem Cell Transplantation and Hepatocyte Growth Factor Combined Treatment for Spinal Cord Injury", CLINICAL RESEARCH, 1 January 2006 (2006-01-01), pages 9 - 14, XP009553129
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
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