Title:
THERAPEUTIC AGENT FOR SUBRETINAL HYPERREFLECTIVE MATERIAL OR RETINAL DISORDERS ACCOMPANYING SUBRETINAL HYPERREFLECTIVE MATERIAL
Document Type and Number:
WIPO Patent Application WO/2021/157681
Kind Code:
A1
Abstract:
The present invention provides a therapeutic agent effective against subretinal hyperreflective material or retinal disorders accompanying subretinal hyperreflective material. Specifically, provided is a therapeutic agent for subretinal hyperreflective material or retinal disorders accompanying subretinal hyperreflective material, the therapeutic agent containing an aptamer that binds to FGF2 or a salt thereof.
Inventors:
NAKAMURA YOSHIKAZU (JP)
FUJIWARA MASATOSHI (JP)
ALI YUSUF (US)
PEREIRA DANIEL (US)
FUJIWARA MASATOSHI (JP)
ALI YUSUF (US)
PEREIRA DANIEL (US)
Application Number:
PCT/JP2021/004215
Publication Date:
August 12, 2021
Filing Date:
February 05, 2021
Export Citation:
Assignee:
RIBOMIC INC (JP)
International Classes:
A61K31/7088; A61K45/00; A61P27/02; C12N15/115
Domestic Patent References:
| WO2020004607A1 | 2020-01-02 | |||
| WO2020004607A1 | 2020-01-02 |
Foreign References:
| JP2009509962A | 2009-03-12 | |||
| JP2020500938A | 2020-01-16 | |||
| US5660985A | 1997-08-26 | |||
| USPP62970842P |
Other References:
MATSUDA YUSAKU, NONAKA YOSUKE, FUTAKAWA SATOSHI, IMAI HIROTAKA, AKITA KAZUMASA, NISHIHATA TOSHIAKI, FUJIWARA MASATOSHI, ALI YUSUF,: "Anti-angiogenic and anti-scarring dual action of an anti-fibroblast growth factor 2 aptamer in animal models of retinal disease", MOL. THER. NUCLEIC ACIDS, vol. 17, 2019, pages 819 - 828, XP055845855
KIMURA, KAZUHIRO: "Action of Sex Hormone for Proliferative Fibrocellular Tissue Formation in Refractory Vitreoretinal Diseases", YAMAGUCHI MEDICAL JOURNAL, vol. 64, 2015, pages 11 - 16, XP055845856
BROWN DM ET AL., N ENGL J MED., vol. 355, no. 14, 5 October 2006 (2006-10-05), pages 1432 - 44
BHISITKUL RB ET AL., OPHTHALMOLOGY, vol. 123, no. 6, June 2016 (2016-06-01), pages 1269 - 77
ALEX S. WILLOUGHBY, BS ET AL., GRAEFES ARCH CLIN EXP OPHTHALMOL, vol. 256, 2018, pages 2089 - 2096
EBENEZER DANIEL ET AL., OPHTHALMOLOGY, vol. 121, no. 3, March 2014 (2014-03-01), pages 656 - 666
CICINELLI, MARIA VITTORIA ET AL., RETIN CASES BRIEF REP., 2019
DANIELA C. FERRARA ET AL., GRAEFES ARCH CLIN EXP OPHTHALMOL., vol. 248, no. 10, October 2010 (2010-10-01), pages 1377 - 1386
SARRA GATTOUSSI ET AL., ACTA OPHTHALMOL., vol. 97, 2019, pages 364 - 371
NIROJ K SAHOO ET AL., INDIAN JOURNAL OF OPHTALMOLOGY, vol. 68, pages 126 - 129
A OZKAYA ET AL., J FR OPHTALMOL., vol. 41, 2018, pages 21 - 29
KIMURA, KAZUHIRO: "Action of Sex Hormone for Proliferative Fibrocellular Tissue Formation in Refractory Vitreoretinal Diseases", YAMAGUCHI MEDICAL JOURNAL, vol. 64, 2015, pages 11 - 16, XP055845856
BROWN DM ET AL., N ENGL J MED., vol. 355, no. 14, 5 October 2006 (2006-10-05), pages 1432 - 44
BHISITKUL RB ET AL., OPHTHALMOLOGY, vol. 123, no. 6, June 2016 (2016-06-01), pages 1269 - 77
ALEX S. WILLOUGHBY, BS ET AL., GRAEFES ARCH CLIN EXP OPHTHALMOL, vol. 256, 2018, pages 2089 - 2096
EBENEZER DANIEL ET AL., OPHTHALMOLOGY, vol. 121, no. 3, March 2014 (2014-03-01), pages 656 - 666
CICINELLI, MARIA VITTORIA ET AL., RETIN CASES BRIEF REP., 2019
DANIELA C. FERRARA ET AL., GRAEFES ARCH CLIN EXP OPHTHALMOL., vol. 248, no. 10, October 2010 (2010-10-01), pages 1377 - 1386
SARRA GATTOUSSI ET AL., ACTA OPHTHALMOL., vol. 97, 2019, pages 364 - 371
NIROJ K SAHOO ET AL., INDIAN JOURNAL OF OPHTALMOLOGY, vol. 68, pages 126 - 129
A OZKAYA ET AL., J FR OPHTALMOL., vol. 41, 2018, pages 21 - 29
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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