Title:
THERAPEUTIC AGENT FOR TRAUMATIC NEUROLOGICAL DISORDERS
Document Type and Number:
WIPO Patent Application WO/2012/074043
Kind Code:
A1
Abstract:
Provided is a novel drug for treating traumatic neurological disorders, i.e., traumatic brain injury or brain injury and/or spinal cord injury associated with brain surgery. As the results of studies on the relation between an external physical force applied on the brain and HMGB1, it was found for the first time that HMGB1, which existed in the nucleus of nerve cells in the normal state, was released to the outside of the nucleus of nerve cells at a damaged site or neighborhood tissues. Based on this finding, it was also clarified that motility disturbance caused by traumatic brain injury or brain injury and/or spinal cord injury associated with brain surgery can be ameliorated by capturing HMGB1 having been released from the nucleus of nerve cells, thereby completing the present invention.
Inventors:
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
TAKAHASHI HIDEO (JP)
WAKE HIDENORI (JP)
LIU KEYUE (JP)
DATE ISAO (JP)
OKUMA YU (JP)
TOMONO YASUKO (JP)
MORI SHUJI (JP)
TAKAHASHI HIDEO (JP)
WAKE HIDENORI (JP)
LIU KEYUE (JP)
DATE ISAO (JP)
OKUMA YU (JP)
TOMONO YASUKO (JP)
Application Number:
PCT/JP2011/077782
Publication Date:
June 07, 2012
Filing Date:
December 01, 2011
Export Citation:
Assignee:
UNIV OKAYAMA NAT UNIV CORP (JP)
SOWAKAI MEDICAL FOUNDATION (JP)
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
TAKAHASHI HIDEO (JP)
WAKE HIDENORI (JP)
LIU KEYUE (JP)
DATE ISAO (JP)
OKUMA YU (JP)
TOMONO YASUKO (JP)
SOWAKAI MEDICAL FOUNDATION (JP)
NISHIBORI MASAHIRO (JP)
MORI SHUJI (JP)
TAKAHASHI HIDEO (JP)
WAKE HIDENORI (JP)
LIU KEYUE (JP)
DATE ISAO (JP)
OKUMA YU (JP)
TOMONO YASUKO (JP)
International Classes:
A61K39/395; A61P25/00
Foreign References:
| JP2007527406A | 2007-09-27 |
Other References:
COHEN, M.J. ET AL.: "Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion", CRIT CARE, vol. 13, no. 6, 2009, pages R174
TSUYOSHI MAEKAWA ET AL.: "Shinshu no Unmei Kettei Inshi HMGB1 o Bunshi Hyoteki to shita Kyumeiteki Chiryoho no Kaihatsu Kyukyu Tobu Gaisho Kanja ni Okeru Kecchu Zuiekichu HMGB1 no Dotai to Seimei Yogo", HEISEI 18 TO 20 NENDO SOGO KENKYU HOKOKUSHO, 2009, pages 35 - 44
KIKUCHI, K. ET AL.: "Musanso Muto Jokenka deno Shinkeiyo Saibo ni Okeru Minocycline no HMGB1 ni Taisuru Koka", THE JAPAN SOCIETY OF NEUROTRAUMATOLOGY PROGRAM SHOROKUSHU, vol. 33, March 2010 (2010-03-01), pages 56
HIROKI TANAKA ET AL.: "Shinkei Saibo Shogai ni yoru Glial Saibo Kasseika ni Okeru HMGB1 no Yakuwari", THE JAPANESE PHARMACOLOGICAL SOCIETY HOKUBUKAI PROGRAM SHOROKUSHU, vol. 61, September 2010 (2010-09-01), pages 14
KIGERL, K.A. ET AL.: "High mobility group box-1 (HMGB1) contributes to post-traumatic spinal cord inflammation", SOCIETY FOR NEUROSCIENCE, 40TH ANNUAL MEETING, November 2010 (2010-11-01), Retrieved from the Internet [retrieved on 20111221]
ESPOSITO, E. ET AL.: "Melatonin reduces stress- activated/mitogen-activated protein kinases in spinal cord injury", JOURNAL OF PINEAL RESEARCH, vol. 46, no. 1, 2009, pages 79 - 86
HIDEAKI NAKAJIMA ET AL.: "Sonsho Sekizui ni Okeru high mobility group box-1(HMGB-1) no Dotai to Yakuwari", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 84, no. 8, August 2010 (2010-08-01), pages S1050
TSUYOSHI MAEKAWA ET AL.: "Shinshu no Unmei Kettei Inshi HMGB1 o Bunshi Hyoteki to shita Kyumeiteki Chiryoho no Kaihatsu Kyukyu Tobu Gaisho Kanja ni Okeru Kecchu Zuiekichu HMGB1 no Dotai to Seimei Yogo", HEISEI 18 TO 20 NENDO SOGO KENKYU HOKOKUSHO, 2009, pages 35 - 44
KIKUCHI, K. ET AL.: "Musanso Muto Jokenka deno Shinkeiyo Saibo ni Okeru Minocycline no HMGB1 ni Taisuru Koka", THE JAPAN SOCIETY OF NEUROTRAUMATOLOGY PROGRAM SHOROKUSHU, vol. 33, March 2010 (2010-03-01), pages 56
HIROKI TANAKA ET AL.: "Shinkei Saibo Shogai ni yoru Glial Saibo Kasseika ni Okeru HMGB1 no Yakuwari", THE JAPANESE PHARMACOLOGICAL SOCIETY HOKUBUKAI PROGRAM SHOROKUSHU, vol. 61, September 2010 (2010-09-01), pages 14
KIGERL, K.A. ET AL.: "High mobility group box-1 (HMGB1) contributes to post-traumatic spinal cord inflammation", SOCIETY FOR NEUROSCIENCE, 40TH ANNUAL MEETING, November 2010 (2010-11-01), Retrieved from the Internet
ESPOSITO, E. ET AL.: "Melatonin reduces stress- activated/mitogen-activated protein kinases in spinal cord injury", JOURNAL OF PINEAL RESEARCH, vol. 46, no. 1, 2009, pages 79 - 86
HIDEAKI NAKAJIMA ET AL.: "Sonsho Sekizui ni Okeru high mobility group box-1(HMGB-1) no Dotai to Yakuwari", THE JOURNAL OF THE JAPANESE ORTHOPAEDIC ASSOCIATION, vol. 84, no. 8, August 2010 (2010-08-01), pages S1050
Attorney, Agent or Firm:
SHOJI, Takashi et al. (JP)
Takashi Shoji (JP)
Takashi Shoji (JP)
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