Title:
THERAPEUTIC AGENTS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/061292
Kind Code:
A3
Abstract:
The present disclosure relates generally to therapeutic agents and related uses thereof, including, agents for reducing leptin in a patient or subject and methods of treatment thereof. The therapeutic agents can comprise (without limitation), an antibody or specific binding fragment thereof, a leptin antagonist, a leptin targeting antisense oligonucleotide, a leptin targeting small interfering RNA (siRNA), a leptin targeting short hairpin RNA (shRNA), and/or a gene editing composition directed to at least one target sequence of a leptin polynucleotide. The therapeutic agents can be used in various methods of treatment, including (without limitation), treating liver fibrosis, cancer, inducing or maintaining weight loss, reducing or preventing weight gain, and increasing insulin sensitivity, among others.
Inventors:
SCHERER PHILIPP (US)
ZHAO SHANGANG (US)
AN ZHIQIANG (US)
ZHANG NINGYAN (US)
ZHAO SHANGANG (US)
AN ZHIQIANG (US)
ZHANG NINGYAN (US)
Application Number:
PCT/US2021/051304
Publication Date:
April 28, 2022
Filing Date:
September 21, 2021
Export Citation:
Assignee:
UNIV TEXAS (US)
International Classes:
A61P3/10; A61P3/04; C07K16/26
Domestic Patent References:
| WO2019241660A2 | 2019-12-19 | |||
| WO2016089829A1 | 2016-06-09 |
Foreign References:
| US20130156781A1 | 2013-06-20 | |||
| US20070071763A1 | 2007-03-29 |
Attorney, Agent or Firm:
HILLMAN, Lisa, M.W. et al. (US)
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