Title:
THERAPEUTIC COMPOSITION CONTAINING CORNEAL ENDOTHELIUM REPLACEMENT CELLS
Document Type and Number:
WIPO Patent Application WO/2023/282337
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a therapeutic composition, in particular, a transplant therapy composition, which allows for cryopreservation without damage to cells due to thawing, and which can be administered to a patient without undergoing an additional process such as washing or centrifuging the thawed cells. A therapeutic composition for transplantation, the therapeutic composition containing corneal endothelium replacement cells that have a CD24-positive phenotype, a phenolphthalein derivative, and a cryoprotectant. Despite containing the cryoprotectant, this therapeutic composition is capable of safe intraocular transplantation. Due to being CD24-positive, the therapeutic composition is expected to have the effect of avoiding phagocytosis.
Inventors:
YOSHIZAKI SHINJI (JP)
HATOU SHIN (JP)
TSUKAMOTO MASASHI (JP)
HATOU SHIN (JP)
TSUKAMOTO MASASHI (JP)
Application Number:
PCT/JP2022/027002
Publication Date:
January 12, 2023
Filing Date:
July 07, 2022
Export Citation:
Assignee:
CELLUSION INC (JP)
International Classes:
A61K35/30; A01N1/02; A61L27/38; A61L27/50; C12N5/071
Domestic Patent References:
| WO2019142833A1 | 2019-07-25 |
Foreign References:
| JP2021052661A | 2021-04-08 | |||
| JP2019510509A | 2019-04-18 | |||
| JP2020073602A | 2020-05-14 | |||
| US198662632190P | ||||
| US194662633208P |
Other References:
HATO, SHIN: "iPSC-derived corneal endothelial cell substitute cells and transplantation method aimed at regenerative medicine for bullous keratopathy", KIKAN GANKA SHUJUTSU - JAPANESE SOCIETY OF OPHTHALMIC SURGEONS.JOURNAL, MEDIKARU AOI SHUPPAN, TOKYO, JP, vol. 32, no. Suppl. 1, 1 January 2018 (2018-01-01), JP , pages 98, XP009542509, ISSN: 0914-6806
NUMA, KOSAKU ET AL.: "O02 Function of Cultured Human Corneal Endothelial Cell and Plasticity of Energy Metabolism", PROGRAMS AND ABSTRACTS OF GENERAL CONFERENCE OF THE 43RD JAPAN CORNEA SOCIETY AND THE 35TH ANNUAL MEETING OF THE KERATOPLASTY SOCIETY OF JAPAN 2019; FEBRUARY 7-9, 2019, JAPAN CORNEA SOCIETY, KERATOPLASTY SOCIETY OF JAPAN, JP, vol. 43rd-35th, 1 January 2019 (2019-01-01) - 9 February 2019 (2019-02-09), JP, pages 50, XP009543203
HATOU SHIN, SHIMMURA SHIGETO: "Review: corneal endothelial cell derivation methods from ES/iPS cells", INFLAMMATION AND REGENERATION, vol. 39, no. 1, 1 December 2019 (2019-12-01), XP055858361, DOI: 10.1186/s41232-019-0108-y
HATOU SHIN, SAYANO TOMOKO, HIGA KAZUNARI, INAGAKI EMI, OKANO YUJI, SATO YASUNORI, OKANO HIDEYUKI, TSUBOTA KAZUO, SHIMMURA SHIGETO: "Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model", STEM CELL RESEARCH, ELSEVIER, NL, vol. 55, 9 August 2021 (2021-08-09), NL , pages 102497, XP055939733, ISSN: 1873-5061, DOI: 10.1016/j.scr.2021.102497
HATOU SSHIMMURA S, INFLAMM REGEN, vol. 39, 2019, pages 19
NAT BIOTECHNOL, vol. 26, 2008, pages 101 - 106
NATURE, vol. 454, no. 7204, 31 July 2008 (2008-07-31), pages 646 - 50
CELL STEM CELL, vol. 4, no. 1, 9 January 2009 (2009-01-09), pages 16 - 9
CELL STEM CELL, vol. 5, no. 5, 6 November 2009 (2009-11-06), pages 491 - 503
CELL STEM CELL, vol. 4, no. 5, 8 May 2009 (2009-05-08), pages 381 - 4
STEM CELL RESEARCH, vol. 55, 2021, pages 102497
STEM CELL RES, vol. 55, August 2021 (2021-08-01), pages 102497
NUMA, KOSAKU ET AL.: "O02 Function of Cultured Human Corneal Endothelial Cell and Plasticity of Energy Metabolism", PROGRAMS AND ABSTRACTS OF GENERAL CONFERENCE OF THE 43RD JAPAN CORNEA SOCIETY AND THE 35TH ANNUAL MEETING OF THE KERATOPLASTY SOCIETY OF JAPAN 2019; FEBRUARY 7-9, 2019, JAPAN CORNEA SOCIETY, KERATOPLASTY SOCIETY OF JAPAN, JP, vol. 43rd-35th, 1 January 2019 (2019-01-01) - 9 February 2019 (2019-02-09), JP, pages 50, XP009543203
HATOU SHIN, SHIMMURA SHIGETO: "Review: corneal endothelial cell derivation methods from ES/iPS cells", INFLAMMATION AND REGENERATION, vol. 39, no. 1, 1 December 2019 (2019-12-01), XP055858361, DOI: 10.1186/s41232-019-0108-y
HATOU SHIN, SAYANO TOMOKO, HIGA KAZUNARI, INAGAKI EMI, OKANO YUJI, SATO YASUNORI, OKANO HIDEYUKI, TSUBOTA KAZUO, SHIMMURA SHIGETO: "Transplantation of iPSC-derived corneal endothelial substitutes in a monkey corneal edema model", STEM CELL RESEARCH, ELSEVIER, NL, vol. 55, 9 August 2021 (2021-08-09), NL , pages 102497, XP055939733, ISSN: 1873-5061, DOI: 10.1016/j.scr.2021.102497
HATOU SSHIMMURA S, INFLAMM REGEN, vol. 39, 2019, pages 19
NAT BIOTECHNOL, vol. 26, 2008, pages 101 - 106
NATURE, vol. 454, no. 7204, 31 July 2008 (2008-07-31), pages 646 - 50
CELL STEM CELL, vol. 4, no. 1, 9 January 2009 (2009-01-09), pages 16 - 9
CELL STEM CELL, vol. 5, no. 5, 6 November 2009 (2009-11-06), pages 491 - 503
CELL STEM CELL, vol. 4, no. 5, 8 May 2009 (2009-05-08), pages 381 - 4
STEM CELL RESEARCH, vol. 55, 2021, pages 102497
STEM CELL RES, vol. 55, August 2021 (2021-08-01), pages 102497
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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