Title:
THERAPEUTIC COMPOSITION CONTAINING ENDOTHELIN AS AN ACTIVE COMPONENT
Document Type and Number:
WIPO Patent Application WO/2012/138043
Kind Code:
A3
Abstract:
The present invention relates to a composition for preventing or treating ischemic disease comprising endothelin or a nucleotide sequence encoding endothelin as an active ingredient, and more particularly to a composition for preventing or treating ischemic heart disease, myocardial infarction, angina pectoris, lower limb artery ischemia, distal limb ischemia and ischemic cerebrovascular disease, wherein the composition is administered by intramuscular injection. According to the present invention, administering endothelin-1 by intramuscular injection may efficiently inhibit the progress of ischemia, fibrosis and tissue necrosis, and induce angiogenesis, such that it is promising for preventing or treating the ischemic disease.
Inventors:
LEE EUN JU (KR)
KIM HYO SOO (KR)
KIM HYO SOO (KR)
Application Number:
PCT/KR2011/010320
Publication Date:
November 29, 2012
Filing Date:
December 29, 2011
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
LEE EUN JU (KR)
KIM HYO SOO (KR)
LEE EUN JU (KR)
KIM HYO SOO (KR)
International Classes:
A61K31/19; A61P9/00; A61P9/10
Domestic Patent References:
| WO2007112069A2 | 2007-10-04 |
Foreign References:
| US20100209433A1 | 2010-08-19 | |||
| US20030104976A1 | 2003-06-05 |
Other References:
HO, M. C. Y. ET AL.: "Endothelin-1 protects astrocytes from hypoxic/ischemic injury.", THE FASEB JOURNAL., vol. 15, 2001, pages 618 - 626
MIMA, T. ET AL.: "Endothelin acts in feline and canine cerebral arteries from the adventitial side.", STROKE., vol. 20, 1989, pages 1553 - 1556
MIMA, T. ET AL.: "Endothelin acts in feline and canine cerebral arteries from the adventitial side.", STROKE., vol. 20, 1989, pages 1553 - 1556
Attorney, Agent or Firm:
YANG, Boo-Hyun (1659-2 Inhundong Gwanak-gu, Seoul 151-832, KR)
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