Title:
THERAPEUTIC COMPOSITIONS FOR REPAIRING CHONDROPATHY
Document Type and Number:
WIPO Patent Application WO/2002/094320
Kind Code:
A1
Abstract:
Therapeutic compositions for repairing chondropathy which contain as the active ingredient a phosphodiesterase (PDE) 4 inhibitor having an effect of inhibiting PDE4. In particular, medicinal compositions containing the PDE4 inhibitor and a biocompatible and biodegradable polymer which exert an excellent effect of repairing cartilage when processed into dosage forms adequate for topical administration to sites suffering from chondropathy, for example, microspherical preparations.
More Like This:
Inventors:
TAKIGAWA MASAHARU (JP)
SAKURAI NAOKI (JP)
TAKAGI TOSHIKI (JP)
YANAKA NORIYUKI (JP)
HORIKIRI YUJI (JP)
TAMURA TAKASHI (JP)
SAKURAI NAOKI (JP)
TAKAGI TOSHIKI (JP)
YANAKA NORIYUKI (JP)
HORIKIRI YUJI (JP)
TAMURA TAKASHI (JP)
Application Number:
PCT/JP2002/004930
Publication Date:
November 28, 2002
Filing Date:
May 22, 2002
Export Citation:
Assignee:
TANABE SEIYAKU CO (JP)
TAKIGAWA MASAHARU (JP)
SAKURAI NAOKI (JP)
TAKAGI TOSHIKI (JP)
YANAKA NORIYUKI (JP)
HORIKIRI YUJI (JP)
TAMURA TAKASHI (JP)
TAKIGAWA MASAHARU (JP)
SAKURAI NAOKI (JP)
TAKAGI TOSHIKI (JP)
YANAKA NORIYUKI (JP)
HORIKIRI YUJI (JP)
TAMURA TAKASHI (JP)
International Classes:
A61K9/16; A61K31/27; A61K31/277; A61K31/343; A61K31/381; A61K31/40; A61K31/4166; A61K31/42; A61K31/423; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4425; A61K31/4453; A61K31/4709; A61K31/4985; A61K31/50; A61K31/501; A61K31/502; A61K31/5025; A61K31/519; A61K31/522; A61K31/5377; A61K31/551; A61P19/02; (IPC1-7): A61K45/00; A61K9/10; A61K9/14; A61K9/19; A61K31/27; A61K31/277; A61K31/343; A61K31/381; A61K31/40; A61K31/4166; A61K31/42; A61K31/423; A61K31/44; A61K31/4409; A61K31/4418; A61K31/4425; A61K31/4453; A61K31/4709; A61K31/4985; A61K31/50; A61K31/501; A61K31/502; A61K31/5025; A61K31/519; A61K31/522; A61K31/5377; A61K31/551; A61K47/14; A61K47/36; A61K47/38; A61P19/02
Domestic Patent References:
| WO1998009961A1 | 1998-03-12 | |||
| WO1995014667A1 | 1995-06-01 |
Foreign References:
| US6011060A | 2000-01-04 | |||
| EP0748805A1 | 1996-12-18 | |||
| EP0557016A1 | 1993-08-25 | |||
| JP2000503678A | 2000-03-28 | |||
| JP2000502724A | 2000-03-07 | |||
| JP2000510105A | 2000-08-08 | |||
| JP2000514804A | 2000-11-07 | |||
| JP2000502350A | 2000-02-29 | |||
| JP2000501741A | 2000-02-15 |
Other References:
TENOR,HERMANN ET AL.: "Phosphodiesterase isoenzyme families in human osteoarthritis chondrocytes-functional importance of phosphodiesterase 4", BRITISH JOURNAL OF PHARMACOLOGY, vol. 135, no. 3, 2002, pages 609 - 618, XP002957336
FRANCISCHI,JANETTI N. ET AL.: "Anti-inflammatory and analogestic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 399, no. 2-3, 2000, pages 243 - 249, XP002957337
HITOSHI SEZAKI: "Drug delivery system (first print)", 1986, NANKODO CO., LTD., XP002957338
See also references of EP 1389467A4
CARDIOL., vol. 12, no. I.I, 1989, pages 561
FRANCISCHI,JANETTI N. ET AL.: "Anti-inflammatory and analogestic effects of the phosphodiesterase 4 inhibitor rolipram in a rat model of arthritis", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 399, no. 2-3, 2000, pages 243 - 249, XP002957337
HITOSHI SEZAKI: "Drug delivery system (first print)", 1986, NANKODO CO., LTD., XP002957338
See also references of EP 1389467A4
CARDIOL., vol. 12, no. I.I, 1989, pages 561
Attorney, Agent or Firm:
Aoyama, Tamotsu (IMP Building 3-7, Shiromi 1-chome, Chuo-k, Osaka-shi Osaka, JP)
Download PDF: