Title:
THERAPEUTIC DRUG FOR PNEUMONIA
Document Type and Number:
WIPO Patent Application WO/2023/037562
Kind Code:
A1
Abstract:
The inventors of the present invention found that a peptide derived from HMGB1 can be used for non-conventional applications such as treatment of pneumonia. The present application provides a non-conventional application of a peptide derived from HMGB1 on the basis of this knowledge.
Inventors:
TAMAI KATSUTO
SHIMBO TAKASHI
YAMAZAKI TAKEHIKO
IMOTO JUN-ICHI
SHIMBO TAKASHI
YAMAZAKI TAKEHIKO
IMOTO JUN-ICHI
Application Number:
PCT/JP2021/034806
Publication Date:
March 16, 2023
Filing Date:
September 22, 2021
Export Citation:
Assignee:
UNIV OSAKA (JP)
STEMRIM INC (JP)
STEMRIM INC (JP)
International Classes:
A61K38/17; A61P11/00; A61P37/06
Domestic Patent References:
| WO2018186480A1 | 2018-10-11 | |||
| WO2008099920A1 | 2008-08-21 |
Foreign References:
| JP2005537253A | 2005-12-08 |
Other References:
OH BINNA; LEE MINHYUNG: "Combined delivery of HMGB-1 box A peptide and S1PLyase siRNA in animal models of acute lung injury", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 175, 18 December 2013 (2013-12-18), AMSTERDAM, NL , pages 25 - 35, XP028820800, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2013.12.008
KIM JIYEON; SONG JIHYUN; LEE MINHYUNG: "Combinational delivery of HMGB1 A box and heparin for acute lung injury", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 213, 1 January 1900 (1900-01-01), AMSTERDAM, NL , XP029259193, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2015.05.094
NAMBA TAKAHIRO; TSUGE MITSURU; YASHIRO MASATO; SAITO YUKIE; LIU KEYUE; NISHIBORI MASAHIRO; MORISHIMA TSUNEO; TSUKAHARA HIROKAZU: "Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus", INFLAMMATION RESEARCH, BIRKHAEUSER VERSLAG , BASEL, CH, vol. 70, no. 10-12, 29 August 2021 (2021-08-29), CH , pages 1101 - 1111, XP037610941, ISSN: 1023-3830, DOI: 10.1007/s00011-021-01496-5
LIMING SHI, GUIXIA LI, WENXIN SHI, GUIRONG TIAN: "HMGB1 signaling blocking protects against carbapenem-resistant klebsiella pneumoniae in a murine model of infection", EXPERIMENTAL LUNG RESEARCH., TAYLOR & FRANCIS GROUP, UK, vol. 44, no. 6, 1 January 2018 (2018-01-01), UK , pages 263 - 271, XP009544366, ISSN: 0190-2148, DOI: 10.1080/01902148.2018.1505976
NOBUYUKI NOSAKA;MASATO YASHIRO;MUTSUKO YAMADA;YOSUKE FUJII;HIROKAZU TSUKAHARA;KEYUE LIU;MASAHIRO NISHIBORI;AKIHIRO MATSUKAWA;TSUNE: "Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice", CRITICAL CARE, BIOMED CENTRAL LTD LONDON, GB, vol. 19, no. 1, 11 June 2015 (2015-06-11), GB , pages 249, XP021227923, ISSN: 1364-8535, DOI: 10.1186/s13054-015-0983-9
ZHAI RUOYANG, BLONDONNET RAIKO, EBRAHIMI EBRAHIM, BELVILLE CORINNE, AUDARD JULES, GROSS CHRISTELLE, CHOLTUS HELENA, HENRIOUX FANNY: "The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study", EXPERIMENTAL CELL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 391, no. 2, 1 June 2020 (2020-06-01), AMSTERDAM, NL , pages 112030, XP093045868, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2020.112030
KIM JIYEON; SONG JIHYUN; LEE MINHYUNG: "Combinational delivery of HMGB1 A box and heparin for acute lung injury", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 213, 1 January 1900 (1900-01-01), AMSTERDAM, NL , XP029259193, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2015.05.094
NAMBA TAKAHIRO; TSUGE MITSURU; YASHIRO MASATO; SAITO YUKIE; LIU KEYUE; NISHIBORI MASAHIRO; MORISHIMA TSUNEO; TSUKAHARA HIROKAZU: "Anti-high mobility group box 1 monoclonal antibody suppressed hyper-permeability and cytokine production in human pulmonary endothelial cells infected with influenza A virus", INFLAMMATION RESEARCH, BIRKHAEUSER VERSLAG , BASEL, CH, vol. 70, no. 10-12, 29 August 2021 (2021-08-29), CH , pages 1101 - 1111, XP037610941, ISSN: 1023-3830, DOI: 10.1007/s00011-021-01496-5
LIMING SHI, GUIXIA LI, WENXIN SHI, GUIRONG TIAN: "HMGB1 signaling blocking protects against carbapenem-resistant klebsiella pneumoniae in a murine model of infection", EXPERIMENTAL LUNG RESEARCH., TAYLOR & FRANCIS GROUP, UK, vol. 44, no. 6, 1 January 2018 (2018-01-01), UK , pages 263 - 271, XP009544366, ISSN: 0190-2148, DOI: 10.1080/01902148.2018.1505976
NOBUYUKI NOSAKA;MASATO YASHIRO;MUTSUKO YAMADA;YOSUKE FUJII;HIROKAZU TSUKAHARA;KEYUE LIU;MASAHIRO NISHIBORI;AKIHIRO MATSUKAWA;TSUNE: "Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice", CRITICAL CARE, BIOMED CENTRAL LTD LONDON, GB, vol. 19, no. 1, 11 June 2015 (2015-06-11), GB , pages 249, XP021227923, ISSN: 1364-8535, DOI: 10.1186/s13054-015-0983-9
ZHAI RUOYANG, BLONDONNET RAIKO, EBRAHIMI EBRAHIM, BELVILLE CORINNE, AUDARD JULES, GROSS CHRISTELLE, CHOLTUS HELENA, HENRIOUX FANNY: "The receptor for advanced glycation end-products enhances lung epithelial wound repair: An in vitro study", EXPERIMENTAL CELL RESEARCH, ELSEVIER, AMSTERDAM, NL, vol. 391, no. 2, 1 June 2020 (2020-06-01), AMSTERDAM, NL , pages 112030, XP093045868, ISSN: 0014-4827, DOI: 10.1016/j.yexcr.2020.112030
Attorney, Agent or Firm:
HOSODA, Yoshinori (JP)
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