Title:
THERAPEUTIC INTERFERING PARTICLES FOR CORONA VIRUS
Document Type and Number:
WIPO Patent Application WO/2022/226423
Kind Code:
A3
Abstract:
Described herein are compositions of recombinant SARS-CoV-2 constructs and particles that can interfere with or block infection of uninfected cells. The compositions and methods described herein are useful for treatment of SARS-Co V-2 infections. The recombinant SARS-CoV-2 construct cannot replicate by itself, but can replicate in the presence of infective SARS-CoV-2 (e.g., replication competent SARS-CoV-2). Thus, the present application in one aspect provides a recombinant SARS-Co V-2 construct (e.g., SARS-CoV-2 TIP) capable of interfering with SARS-CoV-2 replication, wherein the recombinant SARS-CoV-2 construct cannot replicate by itself, and wherein the recombinant SARS-CoV-2 construct can replicate in the presence of SARS-CoV-2.
Inventors:
RODICK ROBERT (US)
WEINBERGER LEOR S (US)
CHATURVEDI SONALI (US)
WEINBERGER LEOR S (US)
CHATURVEDI SONALI (US)
Application Number:
PCT/US2022/026223
Publication Date:
December 15, 2022
Filing Date:
April 25, 2022
Export Citation:
Assignee:
THE J DAVID GLADSTONE INST A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J DAVID GLADSTONE (US)
RODICK ROBERT (US)
RODICK ROBERT (US)
International Classes:
A61P31/14; C07K14/005; C12N15/11
Domestic Patent References:
| WO2021216979A2 | 2021-10-28 |
Foreign References:
| RU2733361C1 | 2020-10-01 | |||
| CN112029781A | 2020-12-04 |
Other References:
DéMOULINS THOMAS; EBENSEN THOMAS; SCHULZE KAI; ENGLEZOU PAVLOS C.; PELLICCIA MARIA; GUZMáN CARLOS A.; RUGGLI NICOLAS; MC: "Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 266, 19 September 2017 (2017-09-19), AMSTERDAM, NL , pages 256 - 271, XP085292691, ISSN: 0168-3659, DOI: 10.1016/j.jconrel.2017.09.018
YANG DONG; LEIBOWITZ JULIAN L.: "The structure and functions of coronavirus genomic 3′ and 5 ", VIRUS RESEARCH, AMSTERDAM, NL, vol. 206, 1 January 1900 (1900-01-01), NL , pages 120 - 133, XP029178954, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2015.02.025
FREED NIKKI E, VLKOVÁ MARKÉTA, FAISAL MUHAMMAD B, SILANDER OLIN K: "Rapid and inexpensive whole-genome sequencing of SARS-CoV-2 using 1200 bp tiled amplicons and Oxford Nanopore Rapid Barcoding", BIOLOGY METHODS AND PROTOCOLS, vol. 5, no. 1, 1 January 2020 (2020-01-01), XP055904595, DOI: 10.1093/biomethods/bpaa014
M. HUANG ET AL.: "Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA", NUCLEIC ACIDS RESEARCH, vol. 18, no. 4, 11 December 1989 (1989-12-11), pages 937 - 947, XP055345599, DOI: 10.1093/nar/18.4.937
YANG DONG; LEIBOWITZ JULIAN L.: "The structure and functions of coronavirus genomic 3′ and 5 ", VIRUS RESEARCH, AMSTERDAM, NL, vol. 206, 1 January 1900 (1900-01-01), NL , pages 120 - 133, XP029178954, ISSN: 0168-1702, DOI: 10.1016/j.virusres.2015.02.025
FREED NIKKI E, VLKOVÁ MARKÉTA, FAISAL MUHAMMAD B, SILANDER OLIN K: "Rapid and inexpensive whole-genome sequencing of SARS-CoV-2 using 1200 bp tiled amplicons and Oxford Nanopore Rapid Barcoding", BIOLOGY METHODS AND PROTOCOLS, vol. 5, no. 1, 1 January 2020 (2020-01-01), XP055904595, DOI: 10.1093/biomethods/bpaa014
M. HUANG ET AL.: "Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA", NUCLEIC ACIDS RESEARCH, vol. 18, no. 4, 11 December 1989 (1989-12-11), pages 937 - 947, XP055345599, DOI: 10.1093/nar/18.4.937
Attorney, Agent or Firm:
BRADLEY, Michelle Celine et al. (US)
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