Title:
THERAPEUTIC MODULATION OF GENES IN MYELOID LINEAGE CELLS AND USES THEREOF IN OPHTHALMOLOGY
Document Type and Number:
WIPO Patent Application WO/2023/212707
Kind Code:
A3
Abstract:
Provided herein are methods for reducing the activation of myeloid lineage cells of a subject by targeting the expression and/or activity of factors that contribute to myeloid cell activation with a therapeutic agent. As a result of these methods, the activity of myeloid lineage cells that contribute to neovascularization in the retina of a subject may be reduced. The methods are useful for the treatment and/or prevention of various retinal diseases and injuries, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), retinitis pigmentosa, or diabetic retinopathy.
Inventors:
SUN YE (US)
WANG TIANXI (US)
WANG TIANXI (US)
Application Number:
PCT/US2023/066379
Publication Date:
November 30, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
CHILDRENS MEDICAL CT CORP (US)
International Classes:
A61K35/15; C12N15/79
Domestic Patent References:
| WO2015123561A2 | 2015-08-20 | |||
| WO2017062672A2 | 2017-04-13 |
Foreign References:
| US20120202733A1 | 2012-08-09 |
Attorney, Agent or Firm:
JULIAN, Victoria, L. et al. (US)
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