Title:
THERAPEUTIC PHARMACEUTICAL AGENT FOR DISEASES ASSOCIATED WITH DECREASE IN FUNCTION OF GNE PROTEIN, FOOD COMPOSITION, AND FOOD ADDITIVE
Document Type and Number:
WIPO Patent Application WO/2010/131712
Kind Code:
A1
Abstract:
Disclosed are a therapeutic pharmaceutical agent for diseases associated with the decrease in the function of GNE protein, a food composition, and a food additive.
The therapeutic pharmaceutical agent is characterized by comprising a compound capable of increasing the quantity of N-acetylneuraminic acid in cells. Examples of the compound to be contained in the therapeutic pharmaceutical agent include N-acetylneuraminic acid, an intermediate produced downstream from N-acetylmannosamine in an N-acetylneuraminic acid biosynthesis pathway, an N-acetylneuraminic acid derivative, an N-acetylmannosamine derivative, an N-acetylneuraminic acid-containing compound, an N-acetylneuraminic acid derivative-containing compound, an N-acetylmannosamine-containing compound, an N-acetylmannosamine derivative-containing compound, an inhibitor of a degrading enzyme for N-acetylneuraminic acid, an inhibitor of a degrading enzyme for N-acetylmannosamine, an inhibitor of a degrading enzyme for the intermediate, and others.
Inventors:
NOGUCHI SATORU (JP)
MALICDAN MAY CHRISTINE (JP)
NISHINO ICHIZO (JP)
MALICDAN MAY CHRISTINE (JP)
NISHINO ICHIZO (JP)
Application Number:
PCT/JP2010/058116
Publication Date:
November 18, 2010
Filing Date:
May 13, 2010
Export Citation:
Assignee:
JAPAN HEALTH SCIENCE FOUND (JP)
NOGUCHI SATORU (JP)
MALICDAN MAY CHRISTINE (JP)
NISHINO ICHIZO (JP)
NOGUCHI SATORU (JP)
MALICDAN MAY CHRISTINE (JP)
NISHINO ICHIZO (JP)
International Classes:
A61K31/7012; A61K31/7016; A61K31/7024; A61P13/12; A61P21/00; A61P43/00; C07H7/027; C07H11/04
Domestic Patent References:
| WO2008150477A2 | 2008-12-11 | |||
| WO1998006418A1 | 1998-02-19 |
Foreign References:
| JP2001240599A | 2001-09-04 | |||
| JP2003292444A | 2003-10-15 | |||
| JP2007061058A | 2007-03-15 | |||
| JPH05105694A | 1993-04-27 |
Other References:
"Towards the development of therapy for distal myopathy with rimmed vacuoles", HEISEI 19 NENDO SOKATSU.BUNTAN KENKYU HOKOKUSHO, April 2008 (2008-04-01), pages 1 - 7
"Towards the development of therapy for distal myopathy with rimmed vacuoles", HEISEI 19 NENDO SOKATSU-BUNTAN KENKYU HOKOKUSHO, April 2008 (2008-04-01), pages 8 - 11
MARJAN HUIZING ET AL.: "N-acetylmannosamine treatment rescues a mouse model of hereditary inclusion body myopathy", GLYCOBIOLOGY, vol. 16, no. 11, November 2006 (2006-11-01), pages 1110 - 1111
"Towards the development of therapy for distal myopathy with rimmed vacuoles", HEISEI 19 NENDO SOKATSU-BUNTAN KENKYU HOKOKUSHO, April 2008 (2008-04-01), pages 8 - 11
MARJAN HUIZING ET AL.: "N-acetylmannosamine treatment rescues a mouse model of hereditary inclusion body myopathy", GLYCOBIOLOGY, vol. 16, no. 11, November 2006 (2006-11-01), pages 1110 - 1111
Attorney, Agent or Firm:
ISSHIKI & CO. (JP)
All international patent business corporation (JP)
All international patent business corporation (JP)
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