Title:
THERAPEUTIC PHARMACEUTICAL COMPOSITION FOR BONE AND SOFT TISSUE TUMORS
Document Type and Number:
WIPO Patent Application WO/2022/244792
Kind Code:
A1
Abstract:
The present invention relates to a conditionally replicating adenovirus which has the E1A gene under expression control by Survivin promoter and in which the E3 region is not deleted, and a therapeutic pharmaceutical composition for bone and soft tissue tumors which has, as an active ingredient, the conditionally replicating adenovirus.
Inventors:
KOSAI KEN-ICHIRO (JP)
NAGANO SATOSHI (JP)
FUTAGAWA TOSHITAKA (JP)
NAGANO SATOSHI (JP)
FUTAGAWA TOSHITAKA (JP)
Application Number:
PCT/JP2022/020609
Publication Date:
November 24, 2022
Filing Date:
May 18, 2022
Export Citation:
Assignee:
WYK BIOTECH PHARMA CO LTD (JP)
International Classes:
A61K35/761; A61P19/00; A61P35/00
Domestic Patent References:
| WO2005012536A1 | 2005-02-10 | |||
| WO2005115476A1 | 2005-12-08 |
Foreign References:
| JP2021084823A | 2021-06-03 |
Other References:
KAMIZONO J, ET AL.: "Survivin-responsive conditionally replicating adenovirus exhibits cancer-specific and efficient viral replication.", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, vol. 65, no. 12, 15 June 2005 (2005-06-15), US, pages 5284 - 5291, XP002997036, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-04-2657
NAGANO S ET AL: "An efficient construction of conditionally replicating adenoviruses that target tumor cells with multiple factors", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 12, no. 18, 1 September 2005 (2005-09-01), GB , pages 1385 - 1393, XP002409299, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302540
FANNY GEORGI; URS F. GREBER: "The Adenovirus Death Protein – a small membrane protein controls cell lysis and disease", FEBS LETTERS, ELSEVIER, AMSTERDAM., NL, vol. 594, no. 12, 19 June 2020 (2020-06-19), NL , pages 1861 - 1878, XP071257033, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13848
MURALI V. K., ORNELLES D. A., GOODING L. R., WILMS H. T., HUANG W., TOLLEFSON A. E., WOLD W. S. M., GARNETT-BENSON C.: "Adenovirus Death Protein (ADP) Is Required for Lytic Infection of Human Lymphocytes", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 88, no. 2, 15 January 2014 (2014-01-15), US , pages 903 - 912, XP093006519, ISSN: 0022-538X, DOI: 10.1128/JVI.01675-13
FARRERA-SAL MARTÍ, DE SOSTOA JANA, NUÑEZ-MANCHÓN ESTELA, MORENO RAFAEL, FILLAT CRISTINA, BAZAN-PEREGRINO MIRIAM, ALEMANY RAMON: "Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 14, 21 July 2020 (2020-07-21), pages 5158, XP093006520, DOI: 10.3390/ijms21145158
SUZUKI KAORI, ALEMANY RAMÓN, YAMAMOTO MASATO, CURIEL DAVID T: "The Presence of the Adenovirus E3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses ", CLINICAL CANCER RESEARCH, vol. 8, 30 November 2002 (2002-11-30), pages 3348 - 3359, XP093006526
THANINDRATARN PICHAYA; DEAN DYLAN C.; FENG WENLONG; WEI RAN; NELSON SCOTT D.; HORNICEK FRANCIS J.; DUAN ZHENFENG: "Cyclin-dependent kinase 12 (CDK12) in chordoma: prognostic and therapeutic value", EUROPEAN SPINE JOURNAL, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 29, no. 12, 1 January 1900 (1900-01-01), Berlin/Heidelberg, pages 3214 - 3228, XP037312988, ISSN: 0940-6719, DOI: 10.1007/s00586-020-06543-z
FARIBA NAVID ET AL., CANCER, vol. 113, no. 2, 2008, pages 419 - 425
A. ITALIANO. ET AL., ANNALS OF ONCOLOGY, vol. 24, 2013, pages 2916 - 2922
ELIZABETH FOX. ET AL., THE ONCOLOGIST, vol. 17, 2012, pages 321
STACCHIOTTI S. ET AL., LANCET ONCOL., vol. 16, no. 2, February 2015 (2015-02-01), pages e71 - 83
IMAI R. ET AL., INT J RADIATION ONCOL BIOL PHYS, vol. 95, no. 1, 2016, pages 322 - 327
LOIC LEBELLEC ET AL., HEMATOLOGY, vol. 95, 2015, pages 125 - 131
NAGANO S. ET AL., GENE THER., vol. 12, no. 18, 2005, pages 1385 - 1393
KAMIZONO J ET AL., CANCER RES, vol. 65, 2005, pages 5284 - 5291
JAMES R. BISCHOFF ET AL., SCIENCE, 18 October 1996 (1996-10-18), pages 373 - 376
KAMIZONO ET AL., CANCER RES, vol. 65, no. 12, 15 June 2005 (2005-06-15), pages 5284 - 5291
FANNY GEORGI ET AL., FEBS LETTERS, vol. 594, 2020, pages 1861 - 1878
CANCER CHEMOTHER PHARMACOL, vol. 77, no. 1, January 2016 (2016-01-01), pages 133 - 46
NAGANO S ET AL: "An efficient construction of conditionally replicating adenoviruses that target tumor cells with multiple factors", GENE THERAPY, NATURE PUBLISHING GROUP, LONDON, GB, vol. 12, no. 18, 1 September 2005 (2005-09-01), GB , pages 1385 - 1393, XP002409299, ISSN: 0969-7128, DOI: 10.1038/sj.gt.3302540
FANNY GEORGI; URS F. GREBER: "The Adenovirus Death Protein – a small membrane protein controls cell lysis and disease", FEBS LETTERS, ELSEVIER, AMSTERDAM., NL, vol. 594, no. 12, 19 June 2020 (2020-06-19), NL , pages 1861 - 1878, XP071257033, ISSN: 0014-5793, DOI: 10.1002/1873-3468.13848
MURALI V. K., ORNELLES D. A., GOODING L. R., WILMS H. T., HUANG W., TOLLEFSON A. E., WOLD W. S. M., GARNETT-BENSON C.: "Adenovirus Death Protein (ADP) Is Required for Lytic Infection of Human Lymphocytes", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 88, no. 2, 15 January 2014 (2014-01-15), US , pages 903 - 912, XP093006519, ISSN: 0022-538X, DOI: 10.1128/JVI.01675-13
FARRERA-SAL MARTÍ, DE SOSTOA JANA, NUÑEZ-MANCHÓN ESTELA, MORENO RAFAEL, FILLAT CRISTINA, BAZAN-PEREGRINO MIRIAM, ALEMANY RAMON: "Arming Oncolytic Adenoviruses: Effect of Insertion Site and Splice Acceptor on Transgene Expression and Viral Fitness", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 21, no. 14, 21 July 2020 (2020-07-21), pages 5158, XP093006520, DOI: 10.3390/ijms21145158
SUZUKI KAORI, ALEMANY RAMÓN, YAMAMOTO MASATO, CURIEL DAVID T: "The Presence of the Adenovirus E3 Region Improves the Oncolytic Potency of Conditionally Replicative Adenoviruses ", CLINICAL CANCER RESEARCH, vol. 8, 30 November 2002 (2002-11-30), pages 3348 - 3359, XP093006526
THANINDRATARN PICHAYA; DEAN DYLAN C.; FENG WENLONG; WEI RAN; NELSON SCOTT D.; HORNICEK FRANCIS J.; DUAN ZHENFENG: "Cyclin-dependent kinase 12 (CDK12) in chordoma: prognostic and therapeutic value", EUROPEAN SPINE JOURNAL, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 29, no. 12, 1 January 1900 (1900-01-01), Berlin/Heidelberg, pages 3214 - 3228, XP037312988, ISSN: 0940-6719, DOI: 10.1007/s00586-020-06543-z
FARIBA NAVID ET AL., CANCER, vol. 113, no. 2, 2008, pages 419 - 425
A. ITALIANO. ET AL., ANNALS OF ONCOLOGY, vol. 24, 2013, pages 2916 - 2922
ELIZABETH FOX. ET AL., THE ONCOLOGIST, vol. 17, 2012, pages 321
STACCHIOTTI S. ET AL., LANCET ONCOL., vol. 16, no. 2, February 2015 (2015-02-01), pages e71 - 83
IMAI R. ET AL., INT J RADIATION ONCOL BIOL PHYS, vol. 95, no. 1, 2016, pages 322 - 327
LOIC LEBELLEC ET AL., HEMATOLOGY, vol. 95, 2015, pages 125 - 131
NAGANO S. ET AL., GENE THER., vol. 12, no. 18, 2005, pages 1385 - 1393
KAMIZONO J ET AL., CANCER RES, vol. 65, 2005, pages 5284 - 5291
JAMES R. BISCHOFF ET AL., SCIENCE, 18 October 1996 (1996-10-18), pages 373 - 376
KAMIZONO ET AL., CANCER RES, vol. 65, no. 12, 15 June 2005 (2005-06-15), pages 5284 - 5291
FANNY GEORGI ET AL., FEBS LETTERS, vol. 594, 2020, pages 1861 - 1878
CANCER CHEMOTHER PHARMACOL, vol. 77, no. 1, January 2016 (2016-01-01), pages 133 - 46
Attorney, Agent or Firm:
UMEDA Shinsuke et al. (JP)
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