Title:
THERAPEUTIC AND PROPHYLACTIC TREATMENT OF AGING AND DISORDERS OF AGING IN HUMANS
Document Type and Number:
WIPO Patent Application WO2003070167
Kind Code:
A3
Abstract:
A method for the treatment and prophylaxis of conditions of aging in humans, such conditions of aging associated with a decreased presence of cell-specific carbonic anhydrase enzymes in the brain, such as conditions associated with chronic neurodegenerative conditions including dementia such as Alzheimer's disease, which method includes the administering over an extended period of time, ranging from 6 months to 5 years, of a pharmaceutically effective, non-toxic amount of a compound that increases the presence of cell-specific carbonic anhydrase enzymes in the brain. That compound may be the cell-specific carbonic anhydrase enzyme, a compound that when absorbed by the body reacts or dissociates to form the cell-specific carbonic anhydrase enzyme, or a compound that promotes the natural generation of the cell-specific carbonic anhydrase enzyme within the body.
Inventors:
RODRIGUEZ VICTORIO C (US)
Application Number:
PCT/US2003/004232
Publication Date:
February 05, 2004
Filing Date:
February 12, 2003
Export Citation:
Assignee:
RODRIGUEZ VICTORIO C (US)
International Classes:
A61K31/00; A61K31/145; A61K31/22; A61K31/405; A61K31/417; A61K31/59; A61K33/30; A61K38/51; A61P25/28; A61K45/00; (IPC1-7): A61K31/593; A61K31/4164; A61K31/315; A61K31/23; A61K31/231; A61K31/232; A61K31/145; A61K33/30; A61K38/43
Domestic Patent References:
| WO2001093744A2 | 2001-12-13 |
Foreign References:
| EP0680960A1 | 1995-11-08 |
Other References:
TOZER M.J. ET AL.: "4-Chlorobenzyl sulfonamide and sulfamide derivatives of histamine homologues: the design of potent histamine H3 receptor antagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 9, 1999, pages 3103 - 3108, XP004181015
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE, (BETHESDA, MD, USA); ONODERA K. ET AL.: "The roles of histamine H3 receptors in the behavioral disorders and neuropsychopharmacological aspects of its ligands in the brain", XP002968991, accession no. STN Database accession no. 1999441621
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE, (BETHESDA, MD, USA); ONODERA K. ET AL.: "The roles of histamine H3 receptors in the behavioral disorders and neuropsychopharmacological aspects of its ligands in the brain", XP002968991, accession no. STN Database accession no. 1999441621
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