Title:
THERAPEUTIC USES OF UROLITHIN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2024/025953
Kind Code:
A3
Abstract:
Disclosed are Urolithin derivatives for use in methods for treating a neuromuscular disorder, muscle disorder, heart disease, pulmonary fibrosis, liver disease, inflammatory bowel disease, or cancer. Also disclosed are Urolithin derivatives for use in a method of enhancing cancer immunotherapy.
Inventors:
GRETEN FLORIAN (DE)
DENK DOMINIC (DE)
ANDREUX PENELOPE (CH)
DUGI KLAUS (CH)
RINSCH CHRISTOPHER (CH)
DENK DOMINIC (DE)
ANDREUX PENELOPE (CH)
DUGI KLAUS (CH)
RINSCH CHRISTOPHER (CH)
Application Number:
PCT/US2023/028706
Publication Date:
March 07, 2024
Filing Date:
July 26, 2023
Export Citation:
Assignee:
VANDRIA SA (CH)
GRETEN FLORIAN (DE)
DENK DOMINIC (DE)
GRETEN FLORIAN (DE)
DENK DOMINIC (DE)
International Classes:
A61K31/335; A61K31/352; A61K31/365; A61K31/366; A61K31/38; A61K31/382; A61K31/453; A61K31/473; A61K31/496; A61K31/5377; A61K31/5415; A61K31/55; A61K45/06; A61P1/00; A61P1/16; A61P9/00; A61P11/00; A61P21/00; A61P25/28; A61P35/00
Domestic Patent References:
| WO2022162471A1 | 2022-08-04 | |||
| WO2014111580A1 | 2014-07-24 | |||
| WO2015097231A1 | 2015-07-02 | |||
| WO2014004902A2 | 2014-01-03 | |||
| WO2014129989A1 | 2014-08-28 | |||
| WO2019222146A1 | 2019-11-21 | |||
| WO2019165372A1 | 2019-08-29 | |||
| WO2002045702A2 | 2002-06-13 | |||
| WO2019084271A1 | 2019-05-02 |
Foreign References:
| US20070197567A1 | 2007-08-23 | |||
| US20050234031A1 | 2005-10-20 |
Other References:
TANG LONG ET AL: "Design, Synthesis, and Biological Evaluation of Novel 6H-Benzo[c]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 22, no. 11, 26 May 2021 (2021-05-26), Basel, CH, pages 5680, XP093122592, ISSN: 1422-0067, DOI: 10.3390/ijms22115680
SAVI MONIA ET AL: "Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide", MOLECULES, vol. 23, no. 3, 1 March 2018 (2018-03-01), CH, pages 549, XP093122624, ISSN: 1420-3049, DOI: 10.3390/molecules23030549
PACHER PÁL ET AL: "Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 40, no. 5, 1 September 2002 (2002-09-01), AMSTERDAM, NL, pages 1006 - 1016, XP093123200, ISSN: 0735-1097, DOI: 10.1016/S0735-1097(02)02062-4
SAVI MONIA ET AL: "Trimethylamine-N-Oxide (TMAO)-Induced Impairment of Cardiomyocyte Function and the Protective Role of Urolithin B-Glucuronide", MOLECULES, vol. 23, no. 3, 1 March 2018 (2018-03-01), CH, pages 549, XP093122624, ISSN: 1420-3049, DOI: 10.3390/molecules23030549
PACHER PÁL ET AL: "Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, vol. 40, no. 5, 1 September 2002 (2002-09-01), AMSTERDAM, NL, pages 1006 - 1016, XP093123200, ISSN: 0735-1097, DOI: 10.1016/S0735-1097(02)02062-4
Attorney, Agent or Firm:
GORDON, Dana, M. (US)
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