Title:
THERMOSENSITIVE MODIFIED CHITIN SPONGE DRUG-LOADED IMPLANTED SUSTAINED-RELEASE SYSTEM, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/208059
Kind Code:
A1
Abstract:
The present invention provides a thermosensitive modified chitin sponge drug-loaded implanted sustained-release system, a preparation method therefor, and use thereof. The system comprises the following components: a spongy matrix, the matrix comprising at least one thermosensitive modified chitin polymer; and at least one drug, the drug being a local anesthetic and analgesic drug and/or an anti-inflammatory and antibacterial drug, and the drug being uniformly dispersed in the matrix.
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Inventors:
JIANG XULIN (CN)
QIAO QIANQIAN (CN)
LI TAOTAO (CN)
YANG FAN (CN)
QIAO QIANQIAN (CN)
LI TAOTAO (CN)
YANG FAN (CN)
Application Number:
PCT/CN2023/090930
Publication Date:
November 02, 2023
Filing Date:
April 26, 2023
Export Citation:
Assignee:
JIANG XULIN (CN)
International Classes:
A61K9/00; A61K45/00; A61K47/36; A61P23/02; A61P29/00
Foreign References:
| CN109432496A | 2019-03-08 | |||
| CN111297513A | 2020-06-19 | |||
| CN103951764A | 2014-07-30 |
Other References:
YANG FAN, QIAO QIANQIAN, CAI MINGZHEN, XIA ZHONGYUAN, JIANG XULIN: "Bupivacaine-loaded hydroxypropyl chitin based sponges prepared via a solvent-free process provide long-acting local anesthesia for postoperative pain", JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, ED. DE SANTé, FR, vol. 73, 1 July 2022 (2022-07-01), FR , pages 103453, XP093102650, ISSN: 1773-2247, DOI: 10.1016/j.jddst.2022.103453
QIAO QIANQIAN, FU XIANGYUN, HUANG RUI, LEI SHAOQING, LENG YAN, LIU ZHIGANG, XIA ZHONGYUAN, JIANG XULIN: "Ropivacaine-loaded,hydroxypropyl chitin thermosensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats", REGIONAL ANESTHESIA AND PAIN MEDICINE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 47, no. 4, 15 February 2022 (2022-02-15), US , pages 234 - 241, XP009549831, ISSN: 1098-7339, DOI: 10.1136/rapm-2021-102726
QIAO QIANQIAN, FU XIANGYUN, HUANG RUI, LEI SHAOQING, LENG YAN, LIU ZHIGANG, XIA ZHONGYUAN, JIANG XULIN: "Ropivacaine-loaded,hydroxypropyl chitin thermosensitive hydrogel combined with hyaluronan: an injectable, sustained-release system for providing long-lasting local anesthesia in rats", REGIONAL ANESTHESIA AND PAIN MEDICINE, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 47, no. 4, 15 February 2022 (2022-02-15), US , pages 234 - 241, XP009549831, ISSN: 1098-7339, DOI: 10.1136/rapm-2021-102726
Attorney, Agent or Firm:
HUBEI WUHAN YONGJIA PATENT AGENCY CO., LTD. (CN)
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