THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Title:

THIADIAZOLEDIOXIDES AND THIADIAZOLEOXIDES AS CXC- AND CC-CHEMOKINE RECEPTOR LIGANDS

Document Type and Number:

WIPO Patent Application WO2004033440

Kind Code:

A8

Abstract:

Disclosed are novel compounds of the formula (IA) and the pharmaceutically acceptable salts and solvates thereof. Examples of groups comprising Substituent A include heteroaryl, aryl, heterocycloalkyl, cycloalkyl, aryl, alkynyl, alkenyl, aminoalkyl, alkyl or amino. Examples of groups comprising Substituent B include aryl and heteroaryl. Also disclosed is a method of treating a chemokine mediated diseases, such as, cancer, angiogenisis, angiogenic ocular diseases, pulmonary diseases, multiple sclerosis, rheumatoid arthritis, osteoarthritis, stroke and cardiac reperfusion injury, acute pain, acute and chronic inflammatory pain, and neuropathic pain using a compound of formula (IA).

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Inventors:

TAVERAS ARTHUR G
CHAO JIANHUA
BIJU PURAKKATTLE J
YU YOUNONG
FINE JAY S
HIPKIN WILLIAM
AKI CYNTHIA J
MERRITT J ROBERT
LI GE
BALDWIN JOHN J
LAI GAIFA
WU MINGLANG
HECKER EVAN A

Application Number:

PCT/US2003/031707

Publication Date:

June 02, 2005

Filing Date:

October 07, 2003

Export Citation:

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Assignee:

SCHERING CORP (US)
PHARMACOPEIA DRUG DISCOVERY (US)

International Classes:

A61K31/433; A61K31/4439; C07D285/10; C07D417/02; C07D417/12; C07D417/14; (IPC1-7): C07D285/10; C07D417/12; C07D417/14; A61K31/433; A61K31/4436

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