Title:
THIENO[2,3-D]PYRIMIDINE HIV-1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/164052
Kind Code:
A1
Abstract:
Disclosed are a thieno[2,3-d]pyrimidine HIV-1 reverse transcriptase inhibitor, DK6-1, a preparation method therefor and the use thereof, a pharmaceutical composition containing DK6-1 and the use of the compound and a composition containing one or more such compounds in the preparation of a drug for treating and preventing human immunodeficiency virus (HIV).
Inventors:
KANG DONGWEI (CN)
LIU XINYONG (CN)
ZHAN PENG (CN)
LIU XINYONG (CN)
ZHAN PENG (CN)
Application Number:
PCT/CN2020/077564
Publication Date:
August 26, 2021
Filing Date:
March 03, 2020
Export Citation:
Assignee:
SHAN DONG UNIV (CN)
International Classes:
C07D495/04; A61K31/519; A61P31/18
Foreign References:
| CN104926829A | 2015-09-23 | |||
| CN104530078A | 2015-04-22 | |||
| CN1322198A | 2001-11-14 | |||
| CN1541215A | 2004-10-27 |
Other References:
KANG, DONGWEI ET AL.: "Structure-Based Optimization of Thiophene[3, 2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants", JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, no. 10, 8 May 2017 (2017-05-08), XP055642174, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.7b00332
Attorney, Agent or Firm:
JINAN JINDI INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
Download PDF: