THIOAMIDES AND SALTS THEREOF AND CYTOKINE PRODUCTION INHIBITORS CONTAINING BOTH

Title:

THIOAMIDES AND SALTS THEREOF AND CYTOKINE PRODUCTION INHIBITORS CONTAINING BOTH

Document Type and Number:

WIPO Patent Application WO/2005/077895

Kind Code:

A1

Abstract:

The invention provides cytokine production inhibitors useful as preventive or therapeutic agents for diseases accompanied with abnormally enhanced immune function. Cytokine production inhibitors containing as the active ingredient thioamides represented by the general formula (I) or salts thereof: wherein A is N, NO, C-NO₂, or C-CN; Hal is halogeno; M¹ is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, a heterocycle, amino, O, S, SO, or SO₂; M² is amino, O, S, or a single bond; R¹ is halogeno, alkyl, or the like; R² R³, R⁴ and R⁵ are each independently H, alkyl, or the like; R⁶ is halogeno, alkyl, or the like; Cy is cycloalkyl, cycloalkenyl, aryl, or a heterocycle; k, p and q are each independently an integer of 0 to 3; and r is an integer of 0 to 5.

Inventors:

KATO FUMINORI (JP)
KIMURA HIROHIKO (JP)
TAMAI KIYOSHI (JP)
YAMAMOTO KAZUHIRO (JP)
SANO MITSUO (JP)
MORI SHINYA (JP)
OKADA TAKASHI (JP)
UEKI TOSHIHIKO (JP)
AZUMA KUMIKO (JP)

Application Number:

PCT/JP2005/002348

Publication Date:

August 25, 2005

Filing Date:

February 16, 2005

Export Citation:

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Assignee:

ISHIHARA SANGYO KAISHA (JP)
KATO FUMINORI (JP)
KIMURA HIROHIKO (JP)
TAMAI KIYOSHI (JP)
YAMAMOTO KAZUHIRO (JP)
SANO MITSUO (JP)
MORI SHINYA (JP)
OKADA TAKASHI (JP)
UEKI TOSHIHIKO (JP)
AZUMA KUMIKO (JP)

International Classes:

A61K31/18; A61K31/352; A61K31/401; A61K31/404; A61K31/4045; A61K31/41; A61K31/415; A61K31/4192; A61K31/423; A61K31/425; A61K31/426; A61K31/428; A61K31/437; A61K31/44; A61K31/4409; A61K31/4439; A61K31/444; A61K31/4545; A61K31/455; A61K31/47; A61K31/4965; A61K31/50; A61K31/505; A61K31/517; A61K31/5377; A61K31/538; A61K31/541; A61P3/10; A61P5/14; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P19/02; A61P21/04; A61P25/00; C07D237/20; A61P27/14; A61P27/16; A61P29/00; A61P37/00; A61P37/06; A61P37/08; A61P43/00; C07C233/66; C07C233/69; C07C233/71; C07C233/78; C07C311/17; C07C323/42; C07C327/48; C07D207/09; C07D209/04; C07D209/08; C07D209/42; C07D213/64; C07D213/69; C07D213/70; C07D213/74; C07D213/81; C07D213/82; C07D213/83; C07D215/20; C07D215/22; C07D231/18; C07D231/20; C07D235/08; C07D237/04; C07D239/30; C07D239/34; C07D239/42; C07D239/60; C07D241/12; C07D241/18; C07D249/18; C07D257/04; C07D263/58; C07D277/20; C07D277/36; C07D277/74; C07D311/08; C07D311/46; C07D401/12; C07D471/04; (IPC1-7): C07C327/48; A61K31/166; A61K31/325; A61K31/275; A61K31/41; A61K31/4164; A61K31/4192; A61K31/426; A61K31/428; A61K31/44; A61K31/4409; A61K31/4412; A61K31/4439; A61K31/444; A61K31/4545; A61K31/455; A61K31/47; A61K31/4709; A61K31/4965; A61K31/505; A61K31/5377; A61P3/10; A61K31/541; A61P5/14; A61P11/02; A61P11/06; A61P17/00; A61P17/04; A61P19/02; A61P21/04; A61P25/00; A61P27/14; A61P29/00; A61P37/02; A61P37/08; A61P43/00

Foreign References:

JP2003506466A	2003-02-18
JP2002503723A	2002-02-05
JPH09176100A	1997-07-08
JPS52100476A	1977-08-23
JP2002338537A	2002-11-27

Other References:

ISAGAWA K. ET AL: "N-(Chlorbenzoyl Amino Alkyl) Piperidine rui no Gosei.", NIHON KAGAKU ZASSHI., vol. 90, no. 10, 1969, pages 1051 - 1053, XP002991832

Attorney, Agent or Firm:

Senmyo, Kenji (38 Kanda-Higashimatsushitacho, Chiyoda-k, Tokyo 42, JP)

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