THIOETHER COMPOUND HAVING SOFT DRUG PROPERTY AND USE THEREOF, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Title:

THIOETHER COMPOUND HAVING SOFT DRUG PROPERTY AND USE THEREOF, AND PHARMACEUTICAL COMPOSITION AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2024/099403

Kind Code:

A1

Abstract:

A thioether compound having a soft drug property and a use thereof, and a pharmaceutical composition and a use thereof. The compound has a structural formula of formula I. A thioether structure in the compound has pharmacological activity, and can be quickly converted into sulfoxide and sulfone metabolites without pharmacological activity according to set metabolic pathways after taking effect. In this way, the toxicity of prototype drugs, active metabolites and reactive metabolites to a body is avoided while drugs take effect, and the safety is relatively higher.

Inventors:

YANG YANQING (CN)
ZHU LI (CN)
LI YULIANG (CN)
ZHANG HUI (CN)
DU DANIEL YUNLONG (CN)

Application Number:

PCT/CN2023/130830

Publication Date:

May 16, 2024

Filing Date:

November 09, 2023

Export Citation:

Click for automatic bibliography generation Help

Assignee:

PRIME GENE THERAPEUTICS CO LTD (CN)

International Classes:

C07D401/12; A61K31/40; A61K31/4439; A61P17/04; A61P29/00; A61P35/00; C07D417/04; C07D417/12

Domestic Patent References:

WO1997028128A1	1997-08-07
WO2018208630A1	2018-11-15

Foreign References:

CN103201274A	2013-07-10
CN1422268A	2003-06-04
CN1425002A	2003-06-18
CN106458952A	2017-02-22
CN108602807A	2018-09-28

Other References:

OHSAWA, TATSUSHI ET AL.: "Novel Synthesis of the Pyrrolizidine Skeleton by Sulfenocycloamination. Total Synthesis of (±)-retronecine and (±)-turneforcidine", JOURNAL OF ORGANIC CHEMISTRY, vol. 48, no. 21, 31 December 1983 (1983-12-31), pages 3644 - 3648, XP001013139, DOI: 10.1021/jo00169a005
VERMA, VISHAL A. ET AL.: "α-Aryl Pyrrolidine Sulfonamides as TRPA1 Sntagonists", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 26, 25 November 2015 (2015-11-25), pages 495 - 498, XP029380254, DOI: 10.1016/j.bmcl.2015.11.088

Attorney, Agent or Firm:

BEIJING HUANRUN LAW FIRM (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: INTERMEDIATES AND PROCESS OF COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE

Next Patent: NITROGEN-CONTAINING SPIROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF