Title:
THIOGLYCOSIDE GLIFLOZIN ANALOGUE, PREPARATION METHOD THEREFOR, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/222144
Kind Code:
A1
Abstract:
An SGLT2 (sodium glucose transport protein 2) inhibitor having a novel molecular structure, a preparation method therefor, and a use thereof. The SGLT2 inhibitor is a thioglycoside gliflozin analogue; same is designed using C-glycoside and O-glycoside gliflozin as templates, and is formed by linking glycosyl and aglycone parts via sulfur atoms. In bioactivity testing, the thioglycoside gliflozin analogue exhibits low cytotoxicity and resistance to β-glucosidase hydrolysis, and the inhibitory activity on SGLT2 is equivalent to a corresponding gliflozin drug, and thus the thioglycoside gliflozin analogue is a potential drug for treating type-2 diabetes. The structural general formula of the thioglycoside gliflozin analogue is as follows: (I).
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Inventors:
DONG HAI (CN)
FENG GUANGJING (CN)
WANG SHIYUN (CN)
LI HAILIN (CN)
FENG GUANGJING (CN)
WANG SHIYUN (CN)
LI HAILIN (CN)
Application Number:
PCT/CN2023/107675
Publication Date:
November 23, 2023
Filing Date:
July 17, 2023
Export Citation:
Assignee:
SHANGHAI KELY BIOPHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/7034; C07H15/203; A61K31/7042; A61K31/7048; A61P3/10; C07H1/00; C07H15/26
Domestic Patent References:
| WO2002044192A1 | 2002-06-06 | |||
| WO2002064606A1 | 2002-08-22 | |||
| WO2005063785A2 | 2005-07-14 | |||
| WO2003011880A1 | 2003-02-13 |
Foreign References:
| CN112538099A | 2021-03-23 | |||
| CN1437608A | 2003-08-20 |
Other References:
罗涛等 (LUO, TAO ET AL.): "通过抑制酰基迁移而改良的硫代糖苷的合成 (Non-official translation: Synthesis of Thioglycosides Improved by Inhibiting Acyl Group Migration)", 中国化学会第三届全国糖化学会 (NON-OFFICIAL TRANSLATION: THE THIRD NATIONAL SACCHARIFICATION SOCIETY OF CHINESE CHEMICAL SOCIETY), 22 September 2019 (2019-09-22)
Attorney, Agent or Firm:
WUHAN CO-HONOR INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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