Title:
THIOPURINE-BASED COMPOUND, COMPOSITION, METHOD OF PREPARATION AND APPLICATIONS
Document Type and Number:
WIPO Patent Application WO/2022/178840
Kind Code:
A1
Abstract:
A compound for measurement of thiopurine pathway directed systems imaging and therapy including a chelator and a thiopurine ligand is provided. A method of synthesizing the compound is also provided, and the compound may be further prepared in pharmaceutical formulations or kits for therapy or molecular imaging.
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Inventors:
CHANG WEI-CHUNG (CN)
YANG DAVID J (CN)
CHUNG MIN-CHING (CN)
KE CHI-SHIANG (CN)
KUO TSUNG-TIEN (CN)
YANG DAVID J (CN)
CHUNG MIN-CHING (CN)
KE CHI-SHIANG (CN)
KUO TSUNG-TIEN (CN)
Application Number:
PCT/CN2021/078187
Publication Date:
September 01, 2022
Filing Date:
February 26, 2021
Export Citation:
Assignee:
SEECURE TAIWAN CO LTD (CN)
International Classes:
C07D473/38; A61K49/00; A61K49/10; A61K51/04; A61P35/00; C07D473/00; C07F15/00
Domestic Patent References:
| WO2007074213A1 | 2007-07-05 |
Foreign References:
| CN101074231A | 2007-11-21 |
Other References:
TSAO NING, CHANDA MITHU, YU DONG-FANG, KURIHARA HIROAKI, ZHANG YIN-HAN, MENDEZ RICHARD, DAVID J.YANG: "99mTc-N4amG: Synthesis biodistribution and imaging in breast tumor-bearing rodents", APPLIED RADIATION AND ISOTOPES, vol. 72, 28 February 2013 (2013-02-28) - 10 October 2012 (2012-10-10), pages 105 - 113, XP055963885, DOI: 10.1016/j.apradiso.2012.07.018
NAM KI SOO, JUNG KI-HYE, CHANG YONGMIN, KIM TAE-JEONG: "Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) Conjugate of [(p-aniline benzothiazole)methyl]pyridine as a Tumor-Targeting MRI Contrast Agent", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 34, no. 12, 20 December 2013 (2013-12-20), KR , pages 3654 - 3658, XP055963889, ISSN: 0253-2964, DOI: 10.5012/bkcs.2013.34.12.3654
See also references of EP 4126867A4
NAM KI SOO, JUNG KI-HYE, CHANG YONGMIN, KIM TAE-JEONG: "Gadolinium Complex of 1,4,7,10-Tetraazacyclododecane-1,4,7-trisacetic acid (DO3A) Conjugate of [(p-aniline benzothiazole)methyl]pyridine as a Tumor-Targeting MRI Contrast Agent", BULLETIN OF THE KOREAN CHEMICAL SOCIETY, vol. 34, no. 12, 20 December 2013 (2013-12-20), KR , pages 3654 - 3658, XP055963889, ISSN: 0253-2964, DOI: 10.5012/bkcs.2013.34.12.3654
See also references of EP 4126867A4
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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