Title:
THREE-DIMENSIONAL IMPLANTABLE MATRIX WITH REDUCED FOREIGN BODY RESPONSE
Document Type and Number:
WIPO Patent Application WO/2022/074427
Kind Code:
A1
Abstract:
An implantable and biodegradable polymeric matrix (10) with reduced foreign body response for the regeneration and/or reconstruction and/or creation of soft and connective tissue and/or organs has: a density equal to or lower than 40 kg/m 3; a plurality of local thicknesses of a solid component (12), with an arithmetic mean equal to or lower than 95 μm, an average size of pores/void spaces (11) equal to or lower than 15,000 μm; a surface roughness R a of the solid component (12) with an arithmetic mean equal to or lower than 3 μm; a contact angle θ of the solid component (12) lower than 110°, preferably in the range 10° to 90° and more preferably in the range 30° to 60°.
Inventors:
GERGES IRINI (IT)
TOCCHIO ALESSANDRO (US)
MARTELLO FEDERICO (IT)
TAMPLENIZZA MARGHERITA (IT)
CHINCARINI GIULIA MARIA FOSCARINA (IT)
KOMAN STEFANO (IT)
TOCCHIO ALESSANDRO (US)
MARTELLO FEDERICO (IT)
TAMPLENIZZA MARGHERITA (IT)
CHINCARINI GIULIA MARIA FOSCARINA (IT)
KOMAN STEFANO (IT)
Application Number:
PCT/IB2020/059352
Publication Date:
April 14, 2022
Filing Date:
October 06, 2020
Export Citation:
Assignee:
TENSIVE SRL (IT)
International Classes:
A61L27/56
Domestic Patent References:
| WO2016038083A1 | 2016-03-17 | |||
| WO2017029633A1 | 2017-02-23 | |||
| WO2017037649A1 | 2017-03-09 |
Foreign References:
| US20200189177A1 | 2020-06-18 |
Other References:
GERGES IRINI ET AL: "Exploring the potential of polyurethane-based soft foam as cell-free scaffold for soft tissue regeneration", ACTA BIOMATERIALIA, ELSEVIER, AMSTERDAM , NL, vol. 73, 12 April 2018 (2018-04-12), pages 141 - 153, XP085403703, ISSN: 1742-7061, DOI: 10.1016/J.ACTBIO.2018.04.011
KUCINSKA-LIPKA J ET AL: "Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications", POLYMER BULLETIN, SPRINGER, HEIDELBERG, DE, vol. 75, no. 5, 25 July 2017 (2017-07-25), pages 1957 - 1979, XP036484320, ISSN: 0170-0839, [retrieved on 20170725], DOI: 10.1007/S00289-017-2124-X
POOJA SINGHAL ET AL: "Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams", JOURNAL OF POLYMER SCIENCE PART B: POLYMER PHYSICS, vol. 50, no. 10, 4 March 2012 (2012-03-04), pages 724 - 737, XP055164907, ISSN: 0887-6266, DOI: 10.1002/polb.23056
ANDERSON, J.M. ET AL.: "Seminars in immunology", 2008, ACADEMIC PRESS, article "Foreign body reaction to biomaterials", pages: 86 - 100
MEMPIN, M. ET AL.: "The A, B and C's of Silicone Breast Implants: Anaplastic Large Cell Lymphoma, Biofilm and Capsular Contracture", MATERIALS, vol. 11.12, 2018, pages 2393
FITZAL, F. ET AL.: "Is breast implant-associated anaplastic large cell lymphoma a hazard of breast implant surgery?", OPEN BIOLOGY, vol. 9.4, 2019, pages 190006
CHHAYA M. P. ET AL.: "Transformation of Breast Reconstruction via Additive Biomanufacturing", SCIENTIFIC REPORTS, vol. 6, 2016, pages 28030
MITSAK, A. G.: "Mechanical characterization and non-linear elastic modelling of poly (glycerol sebacate) for soft tissue engineering", JOURNAL OF THE MECHANICAL BEHAVIOUR OF BIOMEDICAL MATERIALS, vol. 11, 2012, pages 3 - 15, XP028926494, DOI: 10.1016/j.jmbbm.2011.11.003
DADO, D. ET AL.: "Mechanical control of stem cell differentiation", REGENERATIVE MEDICINE, vol. 7, no. 1, 2012, pages 101 - 116, XP055555325, DOI: 10.2217/rme.11.99
RA JO, A. ET AL.: "Fabrication of cylindrical PCL scaffolds using a knitting technique and assessment of cell proliferation in the scaffolds", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 11.1, 2014, pages 16 - 22
JOVER ET AL.: "Inhibition of enzymes involved in collagen cross-linking reduces vascular smooth muscle cell calcification", THE FASEB JOURNAL, 2018
"Extracellular Matrix for Tissue Engineering and Biomaterials", 2018, HUMANA PRESS
KUCINSKA-LIPKA J ET AL: "Polyurethane porous scaffolds (PPS) for soft tissue regenerative medicine applications", POLYMER BULLETIN, SPRINGER, HEIDELBERG, DE, vol. 75, no. 5, 25 July 2017 (2017-07-25), pages 1957 - 1979, XP036484320, ISSN: 0170-0839, [retrieved on 20170725], DOI: 10.1007/S00289-017-2124-X
POOJA SINGHAL ET AL: "Ultra low density and highly crosslinked biocompatible shape memory polyurethane foams", JOURNAL OF POLYMER SCIENCE PART B: POLYMER PHYSICS, vol. 50, no. 10, 4 March 2012 (2012-03-04), pages 724 - 737, XP055164907, ISSN: 0887-6266, DOI: 10.1002/polb.23056
ANDERSON, J.M. ET AL.: "Seminars in immunology", 2008, ACADEMIC PRESS, article "Foreign body reaction to biomaterials", pages: 86 - 100
MEMPIN, M. ET AL.: "The A, B and C's of Silicone Breast Implants: Anaplastic Large Cell Lymphoma, Biofilm and Capsular Contracture", MATERIALS, vol. 11.12, 2018, pages 2393
FITZAL, F. ET AL.: "Is breast implant-associated anaplastic large cell lymphoma a hazard of breast implant surgery?", OPEN BIOLOGY, vol. 9.4, 2019, pages 190006
CHHAYA M. P. ET AL.: "Transformation of Breast Reconstruction via Additive Biomanufacturing", SCIENTIFIC REPORTS, vol. 6, 2016, pages 28030
MITSAK, A. G.: "Mechanical characterization and non-linear elastic modelling of poly (glycerol sebacate) for soft tissue engineering", JOURNAL OF THE MECHANICAL BEHAVIOUR OF BIOMEDICAL MATERIALS, vol. 11, 2012, pages 3 - 15, XP028926494, DOI: 10.1016/j.jmbbm.2011.11.003
DADO, D. ET AL.: "Mechanical control of stem cell differentiation", REGENERATIVE MEDICINE, vol. 7, no. 1, 2012, pages 101 - 116, XP055555325, DOI: 10.2217/rme.11.99
RA JO, A. ET AL.: "Fabrication of cylindrical PCL scaffolds using a knitting technique and assessment of cell proliferation in the scaffolds", TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 11.1, 2014, pages 16 - 22
JOVER ET AL.: "Inhibition of enzymes involved in collagen cross-linking reduces vascular smooth muscle cell calcification", THE FASEB JOURNAL, 2018
"Extracellular Matrix for Tissue Engineering and Biomaterials", 2018, HUMANA PRESS
Attorney, Agent or Firm:
ROBBA, Pierpaolo et al. (IT)
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