Title:
TIACUMICIN PRODUCTION
Document Type and Number:
WIPO Patent Application WO2004014295
Kind Code:
A3
Abstract:
Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
Inventors:
SHUE YOUE-KONG (US)
DU CHI-JEN FRANK (CN)
CHIOU MING-HIS (CN)
WU MEI-CHIAO (CN)
CHEN YUAN-TING (CN)
OKUMU FRANKLIN W (US)
DUFFIELD JONATHAN JAMES (US)
DU CHI-JEN FRANK (CN)
CHIOU MING-HIS (CN)
WU MEI-CHIAO (CN)
CHEN YUAN-TING (CN)
OKUMU FRANKLIN W (US)
DUFFIELD JONATHAN JAMES (US)
Application Number:
PCT/US2003/021977
Publication Date:
April 14, 2005
Filing Date:
July 15, 2003
Export Citation:
Assignee:
OPTIMER PHARMACEUTICALS INC (US)
SHUE YOUE-KONG (US)
DU CHI-JEN FRANK (CN)
CHIOU MING-HIS (CN)
WU MEI-CHIAO (CN)
CHEN YUAN-TING (CN)
OKUMU FRANKLIN W (US)
DUFFIELD JONATHAN JAMES (US)
SHUE YOUE-KONG (US)
DU CHI-JEN FRANK (CN)
CHIOU MING-HIS (CN)
WU MEI-CHIAO (CN)
CHEN YUAN-TING (CN)
OKUMU FRANKLIN W (US)
DUFFIELD JONATHAN JAMES (US)
International Classes:
C12P1/04; A61K31/7048; A61K39/00; A61P1/00; A61P31/04; C07H17/08; C12N1/20; C12P19/62; C12R1/01; (IPC1-7): C12P17/18; A61K31/70
Foreign References:
| US4918174A | 1990-04-17 |
Other References:
DEMAIN ET AL: "Manual of Industrial Microbiology and Biotechnology", 1 January 1986, ISBN: 0914826727, pages: 123 - 126, XP009066373
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