Title:
TISSUE ENGINEERING USING INJECTABLE, OXIDIZED ALGINATE HYDROGELS
Document Type and Number:
WIPO Patent Application WO/2013/025763
Kind Code:
A3
Abstract:
Disclosed herein is a cell implantation pre-matrix composition comprising oxidized high molecular weight alginate and oxidized low molecular weight alginate, for combination with cells and polymerization into a hydrogel. Also disclosed are methods of generating a tissue at a site in a subject by the administration of the hydrogel described herein. The generation of fat tissue in a subject by the methods described herein is envisioned.
Inventors:
MOONEY DAVID J (US)
KIM WOO SEOB (KR)
KIM WOO SEOB (KR)
Application Number:
PCT/US2012/050876
Publication Date:
May 10, 2013
Filing Date:
August 15, 2012
Export Citation:
Assignee:
HARVARD COLLEGE (US)
MOONEY DAVID J (US)
KIM WOO SEOB (KR)
MOONEY DAVID J (US)
KIM WOO SEOB (KR)
International Classes:
A61L27/52; A61L27/40; A61L27/50; A61L27/54; C12N5/071
Foreign References:
| US20080085295A1 | 2008-04-10 | |||
| EP0927196B1 | 2008-11-05 |
Other References:
HAO, X. ET AL.: "Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction", CARDIOVASCULAR RESEARCH, vol. 75, 2007, pages 178 - 185
KONG, H. J. ET AL.: "Quantifying the relation between adhesion ligand-receptor bond formation and cell phenotype", PNAS, vol. 103, 2006, pages 18534 - 18539
KONG, H. J. ET AL.: "Quantifying the relation between adhesion ligand-receptor bond formation and cell phenotype", PNAS, vol. 103, 2006, pages 18534 - 18539
Attorney, Agent or Firm:
RESNICK, David, S. et al. (100 Summer StreetBoston, Massachusetts, US)
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