Title:
TISSUE NON-SPECIFIC ALKALINE PHOSPHATE (TNAP): A THERAPEUTIC TARGET FOR ARTERIAL CALCIFICATION
Document Type and Number:
WIPO Patent Application WO2006039480
Kind Code:
A3
Abstract:
This invention relates generally to the field of mineralization, and specifically to the role of TNAP in regulating the levels of extracellular inorganic pyrophosphate. The invention provides methods for modulating the activity of TNAP activity; methods for screening for modulators of TNAP activity; modulators of TNAP activity; and methods for treating pathologic conditions known of suspected to be affected by modulation of TNAP activity.
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Inventors:
MILLAN JOSE LUIS (US)
Application Number:
PCT/US2005/035180
Publication Date:
August 24, 2006
Filing Date:
September 29, 2005
Export Citation:
Assignee:
BURNHAM INST MEDICAL RESEARCH (US)
MILLAN JOSE LUIS (US)
MILLAN JOSE LUIS (US)
International Classes:
C12N9/16; C07H21/04; C12N1/20; C12N15/00
Foreign References:
| US6905689B2 | 2005-06-14 |
Other References:
DATABASE GENBANK [online] HIRSCH ET AL.: "Human tissue non-specific alkalinephosphatase precursor", Database accession no. (ADP65195)
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