TLR5 LIGANDS, THERAPEUTIC METHODS, AND COMPOSITIONS RELATED THERETO

Title:

TLR5 LIGANDS, THERAPEUTIC METHODS, AND COMPOSITIONS RELATED THERETO

Document Type and Number:

WIPO Patent Application WO/2012/040164

Kind Code:

A3

Abstract:

The disclosure relates to antiviral therapeutic methods and related compositions. In certain embodiments, the disclosure relates to methods of treating or preventing a viral infection by administering a pharmaceutical composition comprising a TLR5 ligand, such as a flagellin, to a subject in need thereof.

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Inventors:

GEWIRTZ ANDREW T (US)
ZHANG BENYUE (US)

Application Number:

PCT/US2011/052301

Publication Date:

June 21, 2012

Filing Date:

September 20, 2011

Export Citation:

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Assignee:

UNIV EMORY (US)
GEWIRTZ ANDREW T (US)
ZHANG BENYUE (US)

International Classes:

A61K38/16; A61K38/17; A61K39/12; A61P31/00; A61P31/12

Foreign References:

US20090297552A1	2009-12-03
US20100104516A1	2010-04-29
US20080124361A1	2008-05-29

Other References:

HUI ZENG ET AL.: "Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apototic pathways", AM J PHYSIOL GASTROINTEST LIVER PHYSIOL., vol. 290, 2006, pages G96 - G108

Attorney, Agent or Firm:

MASON, James, C. et al. (Office of Technology Transfer1599 Clifton Road NE, 4th Floo, Atlanta Georgia, US)

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