TOLUIDINE SULFONAMIDES AND THEIR USE

WIPO Patent Application WO/2010/076033

A9

The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).

ALONSO JORGE (DE)
LOPEZ ARANTXA (DE)
MUELBAIER MARCEL (DE)
AMMENN JOCHEN (DE)
WENDT BERND (DE)
LEWIS JOE (DE)
SCHULTES CRISTOPH (DE)
JANSSEN BERND (US)

PCT/EP2009/009337

August 26, 2010

December 30, 2009

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EUROPEAN MOLECULAR BIOLOGY LAB EMBL (DE)
ELARA PHARMACEUTICALS GMBH (DE)
ALONSO JORGE (DE)
LOPEZ ARANTXA (DE)
MUELBAIER MARCEL (DE)
AMMENN JOCHEN (DE)
WENDT BERND (DE)
LEWIS JOE (DE)
SCHULTES CRISTOPH (DE)
JANSSEN BERND (US)

C07C311/21; A61K31/18; A61K31/341; A61K31/381; A61K31/41; A61P35/00; C07D207/416; C07D213/76; C07D231/42; C07D249/14; C07D257/04; C07D261/16; C07D277/52; C07D307/66; C07D333/36

ZWICKER, Jörk (München, DE)

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