Title:
TOMM6-INTERACTING EXTRACTS AND COMPOUNDS FOR USE IN THE TREATMENT AND PROPHYLAXIS OF NERVOUS SYSTEM DISEASES, ATHEROSCLEROSIS, HEPATITIS B INFECTION AND HUMAN PAPILLOMA VIRUS (HPV) INFECTION
Document Type and Number:
WIPO Patent Application WO/2019/224300
Kind Code:
A3
Abstract:
The present invention is directed to a TOMM6 (Translocase of Outer Membrane 6kDa subunit homologue; Mitochondrial import receptor subunit TOM6 homolog)-interacting plant or fungal extract comprising an anthraquinone or anthraquinone derivative, a TOMM6-interacting anthraquinone or anthraquinone derivative, and TOMM6-interacting compounds for use in the treatment or prophylaxis of a nervous system disease, atherosclerosis, Hepatitis B infection and/or human papilloma virus (HPV) infection. Furthermore, the present invention relates to a corresponding method of therapeutic or prophylactic treatment of a nervous system disease or disorder, atherosclerosis, Hepatitis B infection and/or human papilloma virus (HPV) infection, as well as to a method for the identification of a TOMM6-interacting compound or composition. Also, the present invention provides a non-human transgenic animal expressing a transgenic, preferably human TOMM6 or a TOMM6 homolog.
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Inventors:
QUITTERER URSULA (CH)
ABDALLA SAID (DE)
ABDALLA SAID (DE)
Application Number:
PCT/EP2019/063318
Publication Date:
February 06, 2020
Filing Date:
May 23, 2019
Export Citation:
Assignee:
ETH ZUERICH (CH)
International Classes:
A61K31/421; A61K31/122; A61K31/4418; A61K31/4439; A61K31/454; A61K36/062; A61K36/07; A61K36/09; A61K36/74; A61P25/00; A61P25/28
Foreign References:
| CN105596321A | 2016-05-25 | |||
| KR101841604B1 | 2018-03-26 | |||
| FR2476072A1 | 1981-08-21 |
Other References:
HOFFMANN ET AL: "HIGHER RATE OF NEUROPSYCHIATRIC ADVERSE EVENTS LEADING OT DOLUTEGRAVIR DISCONTINUATION IN WOMEN AND OLDER PATIENTS", HIV MEDICINE,, vol. 18, no. 18, 1 January 2017 (2017-01-01), pages 56 - 63, XP002789818
PFANNER ET AL: "MITOCHONDRIAL BIOGENESIS: THE TOM AND TIM MACHINE", CURRENT BIOLOGY,, vol. 7, 1 January 1997 (1997-01-01), pages R100 - R103, XP002789819, DOI: 10.1016/S0960-9822(06)00048-0
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2008, KORIYAMA Y ET AL: "A retinol binding protein, purpurin protects injury-induced apoptosis and regenerate axons in rat CNS neurons", XP002795707, Database accession no. PREV201200148561
MORI ET AL.: "TOXICITY AND TUMORIGENICITY OF PURPURIN, A NATURAL HYDROXYANTHRAQUINONE IN RATS: INDUCTION OF BLADDER NEOPLASMS", CANCER LETTERS, vol. 102, 1996, pages 193 - 198, XP002795708
DI BARTOLO ET AL.: "TRAIL-DEFICIENCY ACCELERATES VASCULAR CALCIFICATION IN ATHEROSCLEROSIS VIA MODULATION OF RANKL", PLOS ONE, vol. 8, no. 9, E74211, 2013, pages 1 - 9, XP002795709
KACZANOWSKA ET AL.: "DESING, SYNTHESIS AND IN VITRO EVALUATION OF NOVEL AMINOMETHYL-PYRIDINES AS DPP-4 INHIBITORS", ACS MEDICINAL CHEMISTRY LETTERS, vol. 1, 2010, pages 530 - 535, XP002795710
PFANNER ET AL: "MITOCHONDRIAL BIOGENESIS: THE TOM AND TIM MACHINE", CURRENT BIOLOGY,, vol. 7, 1 January 1997 (1997-01-01), pages R100 - R103, XP002789819, DOI: 10.1016/S0960-9822(06)00048-0
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2008, KORIYAMA Y ET AL: "A retinol binding protein, purpurin protects injury-induced apoptosis and regenerate axons in rat CNS neurons", XP002795707, Database accession no. PREV201200148561
MORI ET AL.: "TOXICITY AND TUMORIGENICITY OF PURPURIN, A NATURAL HYDROXYANTHRAQUINONE IN RATS: INDUCTION OF BLADDER NEOPLASMS", CANCER LETTERS, vol. 102, 1996, pages 193 - 198, XP002795708
DI BARTOLO ET AL.: "TRAIL-DEFICIENCY ACCELERATES VASCULAR CALCIFICATION IN ATHEROSCLEROSIS VIA MODULATION OF RANKL", PLOS ONE, vol. 8, no. 9, E74211, 2013, pages 1 - 9, XP002795709
KACZANOWSKA ET AL.: "DESING, SYNTHESIS AND IN VITRO EVALUATION OF NOVEL AMINOMETHYL-PYRIDINES AS DPP-4 INHIBITORS", ACS MEDICINAL CHEMISTRY LETTERS, vol. 1, 2010, pages 530 - 535, XP002795710
Attorney, Agent or Firm:
KASCHE, André (CH)
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