TOPICAL DEPILATING COMPOSITION

FIELD OF THE INVENTION

The present invention relates to hair depilation methods and topically acceptable hair depilation compositions.

BACKGROUND OF THE INVENTION

Electrolysis hair depilation methods are known in the art. However, these methods are generally relatively expensive and require trained personnel to apply the technique. Electrolysis treatments normally require at least several applications spread over a number of weeks before any noticeable result is obtained. These methods are also not always effective and may not remove all unwanted hair. Some such methods also involve the use of caustic reagents which can burn or sting the skin.

Mechanical hair depilation devices that function by pulling hairs from the skin are also known and while they are generally effective and result in immediate hair removal, their use can results in significant pain and substantial reddening of the treated skin. Hair depilation compositions offer an alternative method for hair removal to electrolysis and mechanical depilation methods. Such compositions, however, again typically contain caustic reagents and exert their effect in an abrasive way, destroying skin and hair cells alike. Examples of depilating agents that have previously been used in such compositions include lauryl lsoquinolinium bromide and extract oϊLarrea Divaricata (the active component of which is nordihydroguauretic acid).

SUMMARY OF THE INVENTION

The present invention relates to the use of hair depilation agent(s) in combination with one or more skin penetration solvents for promoting penetration of the agent(s) to hair follicles.

More particularly, in one aspect of the invention there is provided a topical depilation composition comprising at least one depilating agent and at least one

topically acceptable skin penetrating solvent for penetration of the agent to hair follicles of the skin.

Typically, the skin penetrating solvent will comprise a compound with a salicylate functional group, and at least one compound with a pyrrolidone functional group.

Any suitable depilating agent compatible with the skin penetrating solvent may be used in a composition embodied by the invention. Preferably, the depilating agent will be selected from the group consisting of nordihydroguauretic acid and alkyl isoquinolinium salts. In one or more embodiments of the invention, the composition will include both nordihydroguauretic acid and an alkyl isoquinolinium salt.

Nordihydroguauretic acid may be present in the composition in the form of Chaparral or other extract oϊLarrea Divaricata.

In another aspect there is provided a method for hair depilation of skin of a mammal, comprising topically administering an effective amount of a depilating composition of the invention to the skin.

The depilation of hair may for example comprise one or more of removal of at least some hair from the treated skin, a reduction in the density of hair on the skin, and inhibition of hair growth on the skin.

The use of depilating agents in combination with a skin penetrating solvent as described herein may increase the level of depilating agent(s) penetrating the skin to the hair follicles which may over time with one or more treatments as described herein, chemically substantially prevent hair follicle neogenesis. Hence, one or more compositions embodied by the invention may provide increased destruction of the germinative cells of hair follicles. Particularly preferred compositions embodied by the present invention may also provide one or more of relatively pain free hair removal, accelerated hair thinning, substantial hair loss from treated skin, a soothing effect on the skin after depilation, and an increased interval between depilatory treatments.

All publications mentioned in this specification are herein incorporated by reference. Any discussion of documents, acts, materials, devices, articles or the like which has been included in this specification is solely for the purpose of providing a context for the present invention. It is not to be taken as an admission that any or all of these matters form part of the prior art base or were common general knowledge in the

field relevant to the present invention as it existed in Australia or elsewhere before the priority date of this application.

Throughout this specification the word "comprise", or variations such as "comprises" or "comprising", will be understood to imply the inclusion of a stated element, integer or step, or group of elements, integers or steps, but not the exclusion of any other element, integer or step, or group of elements, integers or steps.

The features and advantages of methods of the present invention will become further apparent from the following detailed description of preferred embodiments together with the accompanying drawings.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS OF THE INVENTION

The compound with a salicylate functional group can for example be selected from the group consisting of octyl salicylate (ethylhexyl salicylate), alkyl salicylates, methyl salicylate, ethyl salicylate, oil of wintergreen, isoamyl salicylate, benzyl salicylate, triethanolamine salicylate, salicylaldehyde, sodium salicylate and other halo salts of salicylic acid, salicylic acid, phenylethyl salicylate, magnesium salicylate, choline salicylate, choline magnesium salicylate, acetylsalicylic acid, and salicylamide. Preferably, a C1-C8 alkyl salicylate is used in a depilating composition embodied by the invention and most preferably, the skin penetrating solvent will comprise octyl salicylate.

The compound with the pyrolidone functional group can for example be selected from the group consisting of N-methyl-2-pyrrolidone, 2-pyrrolidone, y-butyrolactone, N-ethyl-2-pyrrolidone, and dimethyl sulfoxide. Preferably, the skin penetrating solvent will comprise N-methyl-2-pyrrolidone.

A skin penetrating solvent may also or alternatively comprise one or more compounds selected from the group consisting of methyl sulfoxide, glycerine, proplylene glycol, glycerol formal, azole compounds, ethylene glycol, ethylene glycol formal, emu oil, omega 3 oil, omega 6 oil and omega 9 oil.

The alkyl isoquinolinium salt will preferably be a Cio - Ci ₄ fatty acid isoquinolinium salt and most preferably, a lauryl isoquinolinium salt. The lauryl isoquinolinium salt is typically selected from the group consisting of lauryl

isoquinolinium bromide, lauryl isoquinolinium chloride, lauryl isoquinolinium iodide and lauryl isoquinolinium fluoride. Preferably, lauryl isoquinolinium bromide is used in a depilating composition of the invention.

It is particularly preferred to use a water extract oϊLarrea Divaricata in a depilating composition as described herein.

The pH of the composition will normally be in a range of from about 2.0 to about 11.0 and preferably, from about 5.5 to about 8.5. The pH can be modified with any suitable acid (eg. phosphoric acid, hydrocloric acid, or a food acid such as citric acid etc ), bases (eg. a hydroxide such as sodium hydroxide, minomethyl propanol, priethanolamine), conventionally known buffer (eg. citrates, acetates, carbonates, phosphates, bicarbonates and the like ), or other organic acid (eg. citrates, acetates, stearates and the like).

Typically, the composition will comprise the at least one depilating agent in an amount of from about 0.0001% w/w to about 90% w/w of the composition, and the skin penetrating solvent in an amount in a range of from about 0.1% w/w to about 90% w/w of the composition. Most preferably, respective of the depilating agents will be present in an amount of from about 1.0% w/w to about 20% w/w of the composition, and the skin penetrating solvent will be present in an amount in a range of from about 1% to about 15% w/w of the composition. A particularly preferred embodiment of a depilating composition of the invention comprises :

(a) from 0.0001 to 90% by weight lauryl isoquinolinium bromide;

(b) from 0.0001% to 90% by weight extract of Larrea Divaricata;

(c) from 0.01% to 90 % by weight N-methyl-2-pyrrolidone; and (d) from 0.01% to 90% by weight octyl salicylate.

Compound (a) will usually be present in a range of from about 0.005% w/w to about 20.0% w/w and more preferably, from 0.1% w/w to 1.0 % w/w.

Compound (b) will usually be present in a range of from about 0.01% w/w to about 20.0% w/w and more preferably, from 0.5% w/w to 6.0%w/w. Compound (c) will usually be present in a range of from about 0.1% w/w to about 20.0%w/w, more preferably from 1% to 6.0% w/w.

Compound (d) will usually be present in a range of from about 0.1% w/w to about 20.0%w/w, more preferably from 2% to 7.0% w/w.

Compositions embodied by the invention can also contain surfactants, solvents, waxes, oils, emollients, essential oils, gelling agents, preservatives and other excipients such as fragrances and colouring agents.

Suitable surfactants include conventional anionic, nonionic and amphoteric surfactants, and combinations thereof. Suitable anionic surfactants include alkali metal (C ₁₂ - ₂₂ ) ^a lkyl sulphates, for instance sodium lauryl sulphate, and sodium laureth sulphate and N-acyl sarcosinates and N-acyl taurines in which the acyl moiety has from 12 to 16 carbon atoms, for instance, N-lauroyl, N-myristoyl and N-palmitoyl sarcosine alkali metal salts. Suitable nonionic surfactants include (Q _-16 )- and (C ₁₂₄₆ )-f ^a tty alcohol polyglycosides, for instance decyl polyglycose or lauryl polyglycose, available under the trade names Plantaren 2000 and Plantaren 1200 (Henkel). Other suitable nonionic surfactants include polycondensates of ethylene oxide and propylene oxide (poloxamers) and polyethoxylated sorbitol monoesters such as the products marketed under the trade name Tween (ICI). Further polycondensates that may be used include polycondesates of ethylene of natural oils, butters and silicone (e.g. castor oil, olive oil, soya oil, almond oil, sunflower oil, cocoa butter, coconut oil, corn oil and the like). Suitable amphoteric surfactants include (long chain alkyl) amido (short chain alkyl) betaines such as coamidopropyl betaine, and coco betaine. In a particularly preferred embodiment, the surfactant system consists of an anionic surfactant, or a combination of an anionic primary surfactant and a nonionic or amphoteric secondary or booster surfactant. Suitable such combinations include an alkali metal (Ci ₂ -i8)alkyl sulphate and a (long chain alkyl) amido (short chain alkyl) betaine or a fatty alcohol polyglycoside and preferably, sodium laureth sulphate and sodium lauryl sulphate, cocamidopropyl betaine, decyl polyglycose, and sodium lauroyl sarcosinate or lauryl polyglycose.

The surfactant is normally a water-soluble non-soap or synthetic organic detergent. Suitable such surfactants include the water-soluble salts of: higher fatty acid monoglyceride monosulphates (for example sodium hydrogenated coconut fatty acid monoglyceride mono sulphate); higher alkyl sulphates (for example sodium lauryl sulphate); alkylarylsulphonates (for example sodium dodecylbenzenesulphonates); and higher alkyl sulphoacetates (for example sodium lauryl sulphoacetate). There may also be used the saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic acids having 12 to 16 carbon atoms in the acyl radical and in which the amino acid

moiety is derived from lower aliphatic saturated mono-aminocarboxylic acids having from 2 to 6 carbon atoms, such as the fatty acid amides of glycine, sarcosine, alanine, 3- aminopropanoic acid and valine, and particularly N-lauroyl, myristoyl and palmitoyl sarcosinate compounds. The surfactant(s) may be present in an amount of from about 0.05% w/w to about 30% w/w of the composition, preferably from 0.5% w/w to 20% w/w and more preferably, from 1% w/w to 15% w/w of the composition.

Generally, the liquid aqueous components in the topical composition will comprise one or more of water, glycerine, sorbitol and/or a glycol, and mixtures thereof. Suitably, the glycol is propylene glycol or a polyethylene glycol. It is also preferred to use a gelling agent in the composition, such as natural or synthetic gums or gum like materials, such as for example, Irish Moss, gum tragacanth, guar gum, sodium carboxymethylcellulose, xanthan gum, carbomer, hydroxyethylcellulose, carrageenan, starch or thickening silica. The gelling agent content of the composition will usually be in an amount up to about 20% w/w of the composition and preferably, in a range of from 0.01% w/w to 5% w/w of the composition.

A composition embodied by the invention may also further comprise one or more of emulsifying waxes, butters and oils, such as natural oils, silicone based oils, and synthetic oils and emollients. Suitable emulsifying waxes include Polawax GP200 (Croda), stearic acid, glyceryl monostearate, cetyl alcohol, stearyl alcohol, cetostearyl alcohol, behenic acid, behenyl alcohol, PEG 100 stearate, PEG 20 stearate and the like. Suitable butters include shea butter, mango butter, cocoa butter and the like. Natural oils that may be used include jojoba oil, olive oil, calendula oil, tea tree oil, soya oil, almond oil, sunflower oil, apricot kernal oil, coconut oil, flaxseed oil, evening primrose oil, corn oil, grape seed oil and castor oil. Suitable synthetic oils and emollients include silicone oils, octyl palmitate, isoproply myristate, isoproply palmitate, caprylic / capric triglycerides, C 12-Cl 5 alkyl lactate, C 12 -C 15 alkyl benzoate and the like. Suitable silicone oils include cyclomethicones, dimethicone, dimethiconol, amodimethicone, and Bis-PEG/PPG- 16/16 PEG/PPG-16/16 dimethicone. Further agents and ingredients conventionally used in the art of topical composition formulations may also be included in compositions of the invention, such as skin healing agents, for example vitamin A, vitamin E, allantoin, alpha bisabalol, comfrey extracts, panthenol, disodium lauriminodipropionate tocopheryl phosphates,

calendula oil, essential oils such as patchouli, cedar, cypress, wintergreen, peppermint, citrius, vanilla, rose, jasmine and the like, colouring agents, preservative such as methyl paraben, ethyl paraben, propyl paraben, butyl paraben, isobutylparaben, isopropylparaben phenoxyethanol, naticide, grapefruit seed extract, rosemary extract, neopien, imidazolidinyl urea, diazolidinyl urea, iodopropynyl butylcarbamate, benzyl alcohol, iodopropynyl butylcarbamate, sodium hydroxymethylglycinate, caprylyl glycol, dehydroacetic acid, sorbic acid, PEG-4 laurate, phenoxypropanol, tea tree oil, chloromethylisothiazoline, methylisothiazoline, methyldibromo gularonitrile, 2-bromo- 2-nitropane-l- 3-diol, DMDM hydantoin, sodium benzoate, sodium hydroxybenzoate, emulsifying agents, silicones, alcohol, and menthol.

Topical compositions as described herein can be provided in various forms such as liquids, gels, sprays, creams, lotions, suspensions, masks, foams, strips, patches, solid and liquid soaps. The compositions may contain conventional base materials, suitable fragrances and/or essential oils as desired, and may be formulated in known manner. Compositions of the present invention can for instance be produced by admixture of the various ingredients.

Suitable topically acceptable carrier formulations and methodology for the preparation of compositions embodied by the present invention is for instance found in handbooks and texts well known to the skilled addressee such as "Remington: The Science and Practice of Pharmacy (Mack Publishing Co., 1995)", the contents of which is incorporated herein in its entirety by reference.

The depilation of hair as described herein may involve regular applications of the relevant composition over a predetermined period of time. For instance, the composition may be topically applied daily, at intervals of 2 or 3 days, or weekly. Preferably, the composition is applied to the skin on a daily basis. Typically, the longer the composition is in contact with the skin, the more effective the hair removal treatment will be. The period over which the composition is regularly applied may be as long as necessary to obtain the desired effect, and can extend for several days up to several months or more. The mammal may be any mammal from which a biological sample may be obtained and subjected to a method embodied by the invention. The mammal, may for instance, be a rodent such as a mouse or rat, cat, dog, primate or human being. Typically, the mammal will be a human being.

The present invention will now be further described by reference to the following non-limiting examples. All weight values shown are % w/w of the relevant composition.

EXAMPLE 1

1.1 Lotion formulations

A skin lotion formulation contains 0.8%w/w lauryl isoquinolinium bromide, 3.0 %w/w of extract oϊLarrea Divaricata, 3.0 % w/w of N-methyl-2-pyrrolidone and 4.0 %w/w octyl salicylate.

A particular example of a skin lotion embodied by the present invention is set out in Table 1.

Table 1: Skin lotion formulation

Amount

Ingredients % w/w q.s to

Water 100%

Glycerine 10.00

Octy Salicylate 5.00

N-Methyl-2-Pyrrolidone 3.00

Extract of Larrea Divaricata 3.00

Cetostearyl Alcohol 2.00

Stearic Acid 2.00

PEG 100 Stearate 2.00

Shea butter 1.50 octyl palmitate 1.00 apricot kernal oil 1.00

Jojoba oil 1.00 flaxseed oil 1.00

Lauryl Isoquinolinium Bromide 0.80 calendula oil 0.50

Aminomethyl propanol 0.60

Bis-PEG/PPG-16/16 PEG/PPG- 16/16. Dimethicone;

Caprylic/Capric Triglyceride 0.50

Polysorbate 20 0.50

D-Panthenol 0.40 disodium lauriminodipropionate tocopheryl phosphates 0.40

Fragrance 0.30 hydrolyzed wheat Protein 0.20

Vitamin E 0.20

Carbomer 0.20

Diazolidinyl Urea 0.20

Methyl paraben 0.20

Proply paraben 0.10

Acrylate/C 10-30 AlkyAcrylate Crosspolymer 0.10

Vitamin A 0.10

To prepare the lotion of Table 1, glycerine, carbomer, methyl paraben, D- panthenol and acrylate/C _lo _ ₃ o alkyacrylate crosspolymer are added to water in a mixing tank with mixing, and the mixture is heated to 75 ⁰ C -8O ⁰ C (step 1). In a side vessel, cetostearyl alcohol, stearic acid, PEG 100 stearate, shea butter, apricot kernal oil, octyl palmitate, Jojoba oil, flaxseed oil, calendula oil, proply paraben and the vitamin E are added and heated to 75 ⁰ C -8O ⁰ C (step 2). The mixture of step 2 is then added to the mixture of step 1 with silverson mixing for 10 mins, and the resulting mixture is then allowed to cool to 5O ⁰ C -55 ⁰ C with further mixing. Aminomethyl propanol premixed with water is then added to the batch, and the batch cooled to 35 ⁰ C -4O ⁰ C with mixing. Bis-PEG/PPG- 16/16 PEG/PPG- 16/16. dimethicone; caprylic/capric triglyceride, vitamin A, disodium lauriminodipropionate tocopheryl phosphates, fragrance and hydrolyzed wheat protein are also premixed and added to the batch with mixing. To this mixture is added premixed octy salicylate, extract of Larrea Divaricata, lauryl isoquinolinium bromide, polysorbate 20, N-methyl-2-pyrrolidone, prior to diazolidinyl ureapremixed with water, also with mixing.

1.2 Shaving creams

A number of shaving cream compositions are exemplified below. In general, shaving cream compositions will contain higher concentrations of the selected depilating agents in view of the reduced period of time that shaving formulations are typically in contact with the skin.

In one exemplary form, a shaving cream formulation contains 0.3%w/w lauryl isoquinolinium bromide, 2.0 %w/w of extract of Larrea Divaricata, 2.0 %w/w N- methyl-2-pyrrolidone and 5.0 %w/w of octyl salicylate. Further examples of shaving creams are set out in Table 2 and Table 3.

Table 2: Shaving cream formulation

Amount

Ingredient % w/w q.s to

Water 100%

Stearic Acid 12.00

Sodium Laureth Sulphate 6.00

Glycerine 5.00

Octy Salicylate 5.00

Olive oil 2.00

N-Methyl-2-Pyrrolidone 2.00

Extract of Larrea Divaricata 1.50

Cetostearyl Alcohol 1.50

PEG 20 Stearate 1.50

PEG35 castor oil 1.00

Jojoba oil 1.00

Aminomethyl propanol 0.80

Lauryl Isoquinolinium Bromide 0.30

Fragrance 0.30 hydroxyethylcellulose 0.30

D-Panthenol 0.20 disodium lauriminodipropionate tocopheryl phosphates 0.20 hydrolyzed wheat Protein 0.20

Diazolidinyl Urea 0.20

Methyl paraben 0.20

Proply paraben 0.10

To prepare the shaving cream of Table 2, glycerine, hydroxyethylcellulose, methyl paraben and D-panthenol are added to a mixing tank with mixing, and the mixture is heated to 75 ⁰ C -8O ⁰ C (step 1). Cetostearyl alcohol, stearic acid, PEG 100 stearate, olive oil, jojoba oil, and proply paraben are added to a separate vessel and heated to 75 ⁰ C -8O ⁰ C (step 2). The mixture of step 2 to is then added to the mixture of step 1 with silverson mixing for 10 mins, and the resulting mixture is allowed to cool to 5O ⁰ C -55 ⁰ C with further mixing. Aminomethyl propanol premixed with water is then added to the batch and the batch is cooled batch to 35 -4O ⁰ C with mixing. Sodium laureth sulphate, PEG35 castor oil, disodium lauriminodipropionate tocopheryl phosphates, fragrance and hydrolyzed wheat protein are then also added to the batch with further mixing. To the batch is then added premixed octy salicylate , extract of Larrea Divaricata, lauryl isoquinolinium bromide, N-methyl-2-pyrrolidone, prior to diazolidinyl urea premixed with water, also with mixing.

Table 3: Shaving cream formulation

Amount

Ingredient % w/w q.s to

Water 100%

Stearic Acid 12.00

Sodium Laureth Sulphate 6.00

Glycerine 5.00

Octy Salicylate 4.00

Olive oil 2.00

N-Methyl-2-Pyrrolidone 2.00

Cocamide DEA 2.00

Extract of Larrea Divaricata 1.50

Cetostearyl Alcohol 1.50

Cocamidopropyl betaine 1.50

PEG 20 Stearate 1.50

Polysorbate 20 1.00

Jojoba oil 1.00

Aminomethyl propanol 0.80

Lauryl Isoquinolinium Bromide 0.20

Fragrance 0.30 hydroxyethylcellulose 0.30

D-Panthenol 0.20 disodium lauriminodipropionate tocopheryl phosphates 0.20 hydrolyzed wheat Protein 0.20

Vitamin E 0.20

Diazolidinyl Urea 0.20

Methyl paraben 0.20

Proply paraben 0.10

To prepare the shaving cream of Table 3, glycerine, hydroxyethylcellulose, methyl paraben and D-panthenol are added to water in a mixing tank, and the mixture is heated to 75 -8O ⁰ C. In a side vessel, cetostearyl alcohol, stearic acid, PEG 100 stearate, olive oil, jojoba oil, PEG 20 stearate, cetostearyl alcohol , vitamin E and proply paraben are added and heated to 75 -8O ⁰ C. The mixture of step 2 to is then added to the mixure of step 1 with silverson mixing for 10 mins, and the batch is allowed to cool to 5O ⁰ C - 55 ⁰ C with mixing. Aminomethyl propanol premixed with water are then add to the batch, and the batch is allowed to cool to 35 -4O ⁰ C with mixing. Sodium laureth sulphate, cocamide DEA, cocamidopropyl betaine, polysorbate 20, disodium lauriminodipropionate tocopheryl phosphates, fragrance and hydrolyzed wheat protein

are then also added with mixing. Premixed octy salicylate , extract of Larrea Divaricata, lauryl isoquinolinium bromide, N-methyl-2-pyrrolidone are then added to the batch, prior to diazolidinyl urea premixed with water, also with mixing.

1.3 Aftershave lotions

Examples of aftershave lotions embodied by the present invention are set out in Table 4 and Table 5.

Table 4: Aftershave lotion formulation

Amount

% w/w

Ingredient q.s to

Water 100%

Glycerine 5.00

Octy Salicylate 4.00

N-Methyl-2-Pyrrolidone 3.00

Extract of Larrea Divaricata 3.00

C 12 -C 15 alkyl benzoate 2.00

Cetostearyl Alcohol 2.00

Stearic Acid 2.00

PEG 20 Stearate 2.00 calendula oil 1.00

Shea butter 1.00

Jojoba oil 1.00

Lauryl Isoquinolinium Bromide 0.80

Bisabolol 0.60

Aminomethyl propanol 0.60

Bis-PEG/PPG-16/16 PEG/PPG- 16/16. Dimethicone;

Caprylic/Capric Triglyceride 0.50

Tea tree oil 0.50

D-Panthenol 0.40 disodium lauriminodipropionate tocopheryl phosphates 0.40

Fragrance 0.30 hydrolyzed wheat Protein 0.20

Vitamin E 0.20

Carbomer 0.20

Diazolidinyl Urea 0.20

Methyl paraben 0.20

Proply paraben 0.10

Acrylate/C 10-30 AlkyAcrylate Crosspolymer 0.10

To prepare the aftershave lotion of Table 4, glycerine, carbomer, methyl paraben, D-panthenol and acrylate/C 10-30 alkyacrylate crosspolymer are added to

water in a mixing tank, and heated to 75 -8O ⁰ C (step 1). Cetostearyl alcohol, stearic acid, PEG 20 stearate, shea butter, C12 -C15 alkyl benzoate, jojoba oil, calendula oil, proply paraben and vitamin E are added to a side vessel and heated to 75 ⁰ C -8O ⁰ C (step T). The mixture of step 1 is then aded to the mixture of step 2 with silverson mixing for 10 mins, and the batch is allowed to cool to 5O ⁰ C -55 ⁰ C with mixing. Aminomethyl propanol premixed with water is then add to the batch, and the batch is coolto 35 ⁰ C - 4O ⁰ C with mixing. Bis-PEG/PPG- 16/16 PEG/PPG- 16/16. dimethicone; caprylic/capric triglyceride, disodium lauriminodipropionate tocopheryl phosphates, fragrance , tea tree oil , bisabolol and hydrolyzed wheat protein are then premixed and also add to the batch with further mixing. Premixed octy salicylate , extract oϊLarrea Divaricata, lauryl isoquinolinium bromide, Polysorbate 20, N-methyl-2-pyrrolidone is then added to the batch, prior to diazolidinyl urea premixed with water, also with mixing.

Table 5: Aftershave lotion formulation

Amount

Ingredient % w/w q.s to

Water 100%

Glycerine 5.00

Octy Salicylate 4.00

N-Methyl-2-Pyrrolidone 3.00

Extract of Larrea Divaricata 3.00

Cetostearyl Alcohol 2.00

Stearic Acid 2.00

PEG 100 Stearate 2.00 octyl palmitate 1.00

C 12-Cl 5 alkyl Lactate 1.00 calendula oil 1.00

Shea butter 1.00

Jojoba oil 1.00

Lauryl Isoquinolinium Bromide 0.80

Bisabolol 0.60

Aminomethyl propanol 0.60

Bis-PEG/PPG-16/16 PEG/PPG- 16/16. Dimethicone;

Caprylic/Capric Triglyceride 0.50

Polysorbate 20 0.50

Tea tree oil 0.50

D-Panthenol 0.40 disodium lauriminodipropionate tocopheryl phosphates 0.40

Fragrance 0.30 hydrolyzed wheat Protein 0.20

Vitamin E 0.20

Carbomer 0.20

Diazolidinyl Urea 0.20

Methyl paraben 0.20

Proply paraben 0.10

Acrylate/C 10-30 AlkyAcrylate Crosspolymer 0.10

Vitamin A 0.10

To prepare the aftershave lotion of Table 5, glycerine, carbomer, methyl paraben, D-panthenol and acrylate/C 10-30 alkyacrylate crosspolymer are added to water in a mixing tank, and heated heated to 75 ⁰ C -8O ⁰ C (step 1). Cetostearyl alcohol, stearic acid, PEG 100 stearate, shea butter, C ₁₂ -C _1S alkyl lactate, jojoba oil, octyl palmitate, calendula oil, proply paraben and vitamin E are added to a side vessel and heated to 75 ⁰ C -8O ⁰ C (step 2). The mixture of step 2 to is then added to the mixture of step 1 with silverson mixing for 10 mins, and the batch allowed to cool to 5O ⁰ C -55 ⁰ C with mixing. Aminomethyl propanol premixed with water is then added to the batch, and the batch cooled to 35 ⁰ C -4O ⁰ C with further mixing. Bis-PEG/PPG-16/16 PEG/PPG- 16/16. dimethicone; caprylic/capric triglyceride, vitamin A, disodium lauriminodipropionate tocopheryl phosphates, fragrance , tea tree oil, bisabolol and hydrolyzed wheat protein are then premixed and added to the batch with further mixing. Subsequently, premixed octy salicylate , extract oϊLarrea Divaricata, lauryl isoquinolinium bromide, Polysorbate 20, N-methyl-2-pyrrolidone, is added to the batch with mixing prior to the addition of diazolidinyl urea premixed with water, also with mixing.

EXAMPLE 2

The shaving cream of Table 1 was used every morning with a razor to shave off facial hair. The aftershave lotion of Table 4 was also applied to the face morning and evening. After a 1 month facial hair were approximately 50% thinner and the density of the facial hair was about 55% less. Another noticeable effect observed was that the face was lighter due to a major decrease in the amount of facial hair. Also, an increase of about 8 hours was obtained before there was noticeable facial hair "stubble" regrowth following shaving. The skin of the face also appeared and felt smooth to the touch during this period.

The aftershave lotion was also applied to the back of the neck for the 3 month period. At the end of this period, hair fibres were considered to be about 90% thinner, and hair density was considered about 80% less than that prior to the commencement of the treatment.

Although the present invention has been exemplified with reference to a number of embodiments, it will be appreciated by persons skilled in the art that numerous variations and/or modifications may be made to the invention without departing from the spirit or scope of the invention as broadly described. The present embodiments are, therefore, to be considered in all respects as illustrative and not restrictive.