Title:
TPK AGONIST AND METHOD FOR TREATING NEURODEGENERATIVE DISEASES USING SAME
Document Type and Number:
WIPO Patent Application WO/2024/012554
Kind Code:
A1
Abstract:
The present disclosure belongs to the field of biomedicine, and specifically relates to a method for preventing or treating neurodegenerative diseases or alleviating symptoms of neurodegenerative diseases. Said method comprises administering an effective amount of a thiamine pyrophosphokinase (TPK) agonist to an individual in need of said agonist.
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Inventors:
MENG LIJUAN (CN)
JING HEFENG (CN)
ZHANG HUAN (CN)
JING HEFENG (CN)
ZHANG HUAN (CN)
Application Number:
PCT/CN2023/107391
Publication Date:
January 18, 2024
Filing Date:
July 14, 2023
Export Citation:
Assignee:
SHANGHAI RAISING PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K31/4365; A61K31/437; A61K31/4985; A61P25/00; A61P25/28; C07D239/70; C07D279/32
Domestic Patent References:
| WO2015070237A1 | 2015-05-14 | |||
| WO2009106534A1 | 2009-09-03 | |||
| WO2012025155A1 | 2012-03-01 | |||
| WO1990015607A1 | 1990-12-27 | |||
| WO1995032205A1 | 1995-11-30 |
Foreign References:
| CN106074546A | 2016-11-09 | |||
| CN1418215A | 2003-05-14 | |||
| CN103298460A | 2013-09-11 | |||
| CN109793765A | 2019-05-24 | |||
| US20140057900A1 | 2014-02-27 | |||
| US20140163012A1 | 2014-06-12 | |||
| CN109988093A | 2019-07-09 |
Other References:
DATABASE Registry 13 February 2009 (2009-02-13), ANONYMOUS: "4H-Pyrimido[5,4-b]indol-4-one, 8-fluoro-3,5-dihydro-3-[3-oxo-3-[4-[3- (trifluoromethyl)phenyl]-1-piperazinyl]propyl]- (CA INDEX NAME)", XP093128720, retrieved from STNext Database accession no. 1105201-15-7
BERND MOOSMANN ET AL.: "Protective Activity of Aromatic Amines and Imines against Oxidative Nerve Cell Death.", BIOLOGICAL CHEMISTRY, vol. 382, 30 November 2001 (2001-11-30), XP009062916, DOI: 10.1515/BC.2001.195
ERYAN GUO ET AL.: "Effects of Picrasma Quassioides and its Active Constituents on Alzheimer's Disease In Vitro and In Vivo.", BIOORGANIC CHEMISTRY, vol. 92, 5 September 2019 (2019-09-05), XP085857954, DOI: 10.1016/j.bioorg.2019.103258
LABRIÈRE CHRISTOPHE, LOZACH OLIVIER, BLAIRVACQ MÉLINA, MEIJER LAURENT, GUILLOU CATHERINE: "Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 124, 1 November 2016 (2016-11-01), AMSTERDAM, NL , pages 920 - 934, XP093128711, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2016.08.069
CHEN, GANG ET AL.: "Natural Therapeutic Agents for Neurodegenerative Diseases from the Shells of Xanthoceras sorbifolium.", BIOORGANIC CHEMISTRY, vol. 101, 24 June 2020 (2020-06-24), XP086227766, DOI: 10.1016/j.bioorg.2020.104038
DANIELA KARLSSON; ADYARY FALLARERO; GERDA BRUNHOFER; CLAUDIA MAYER; OHM PRAKASH; C. GOPI MOHAN; PIA VUORELA; THOMAS ERKER;: "The exploration of thienothiazines as selective butyrylcholinesterase inhibitors", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 47, no. 1, 25 May 2012 (2012-05-25), NL , pages 190 - 205, XP028450178, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2012.05.014
DONNIER-MARÉCHAL MARION, CARATO PASCAL, LE BROC DELPHINE, FURMAN CHRISTOPHE, MELNYK PATRICIA: "Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 92, 1 March 2015 (2015-03-01), AMSTERDAM, NL , pages 575 - 582, XP093128712, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.01.013
RUDRAKSHULA MADHAVACHARY; NAGANABOINA NAVEEN; YUANZE WANG; QIAN WANG; MARKELLA KONSTANTINIDOU; ALEXANDER DÖMLING: "β‐Carbolinone Analogues from the Ugi Silver Mine", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2018, no. 24, 15 June 2018 (2018-06-15), DE , pages 3139 - 3143, XP072124312, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800557
PUROHIT, P. ET AL.: "Diversity Oriented Synthesis of beta-Carbolinone and Indolo-Pyrazinone Analogues Based on an Ugi Four Component Reaction and Subsequent Cyclization of the Resulting Indole Intermediate.", CHEMINFORM, vol. 47, no. 28, 31 December 2016 (2016-12-31)
BERND MOOSMANN ET AL.: "Protective Activity of Aromatic Amines and Imines against Oxidative Nerve Cell Death.", BIOLOGICAL CHEMISTRY, vol. 382, 30 November 2001 (2001-11-30), XP009062916, DOI: 10.1515/BC.2001.195
ERYAN GUO ET AL.: "Effects of Picrasma Quassioides and its Active Constituents on Alzheimer's Disease In Vitro and In Vivo.", BIOORGANIC CHEMISTRY, vol. 92, 5 September 2019 (2019-09-05), XP085857954, DOI: 10.1016/j.bioorg.2019.103258
LABRIÈRE CHRISTOPHE, LOZACH OLIVIER, BLAIRVACQ MÉLINA, MEIJER LAURENT, GUILLOU CATHERINE: "Further investigation of Paprotrain: Towards the conception of selective and multi-targeted CNS kinase inhibitors", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 124, 1 November 2016 (2016-11-01), AMSTERDAM, NL , pages 920 - 934, XP093128711, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2016.08.069
CHEN, GANG ET AL.: "Natural Therapeutic Agents for Neurodegenerative Diseases from the Shells of Xanthoceras sorbifolium.", BIOORGANIC CHEMISTRY, vol. 101, 24 June 2020 (2020-06-24), XP086227766, DOI: 10.1016/j.bioorg.2020.104038
DANIELA KARLSSON; ADYARY FALLARERO; GERDA BRUNHOFER; CLAUDIA MAYER; OHM PRAKASH; C. GOPI MOHAN; PIA VUORELA; THOMAS ERKER;: "The exploration of thienothiazines as selective butyrylcholinesterase inhibitors", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, ELSEVIER AMSTERDAM, NL, vol. 47, no. 1, 25 May 2012 (2012-05-25), NL , pages 190 - 205, XP028450178, ISSN: 0928-0987, DOI: 10.1016/j.ejps.2012.05.014
DONNIER-MARÉCHAL MARION, CARATO PASCAL, LE BROC DELPHINE, FURMAN CHRISTOPHE, MELNYK PATRICIA: "Synthesis and pharmacological evaluation of benzannulated derivatives as potent and selective sigma-1 protein ligands", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 92, 1 March 2015 (2015-03-01), AMSTERDAM, NL , pages 575 - 582, XP093128712, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2014.01.013
RUDRAKSHULA MADHAVACHARY; NAGANABOINA NAVEEN; YUANZE WANG; QIAN WANG; MARKELLA KONSTANTINIDOU; ALEXANDER DÖMLING: "β‐Carbolinone Analogues from the Ugi Silver Mine", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, WILEY-VCH, DE, vol. 2018, no. 24, 15 June 2018 (2018-06-15), DE , pages 3139 - 3143, XP072124312, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800557
PUROHIT, P. ET AL.: "Diversity Oriented Synthesis of beta-Carbolinone and Indolo-Pyrazinone Analogues Based on an Ugi Four Component Reaction and Subsequent Cyclization of the Resulting Indole Intermediate.", CHEMINFORM, vol. 47, no. 28, 31 December 2016 (2016-12-31)
Attorney, Agent or Firm:
NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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