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Title:
TRANS-2-DECENOIC ACID DERIVATIVE AND MEDICAMENT CONTAINING SAME
Document Type and Number:
WIPO Patent Application WO/2012/060396
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel trans-2-decenoic acid derivative and a pharmaceutically acceptable salt thereof, and a medicament containing the compound described above as an active component and having a neurotrophic factor-like effect and a side effect reducing effect due to administration of anti-cancer agent which are highly safe. A trans-2-decenoic acid derivative or the pharmaceutically acceptable salt thereof, which is a compound of the present invention, is specifically represented by general formula (1) (where Y represents -O-, -NR-, or -S-, R represents a hydrogen atom, an alkyl group, a dialkylamino group, or the like, and W represents a substituent such as a dialkylaminoalkyl group), and is extremely highly useful as a preventive or therapeutic agent for dementia, Alzheimer's disease, Parkinson's disease, depression and the like, a therapeutic or repairing agent for spinal cord injury, or a medicament such as an agent for reducing the side effect due to administration of anti-cancer agent.

Inventors:
IINUMA MUNEKAZU (JP)
FURUKAWA SHOEI (JP)
NAIKI MITSURU (JP)
MATSUMOTO TOMONORI (JP)
SUGIMOTO HACHIRO (JP)
Application Number:
PCT/JP2011/075228
Publication Date:
May 10, 2012
Filing Date:
November 01, 2011
Export Citation:
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Assignee:
NAGOYA IND SCIENCE RES INST (JP)
NIPPON ZOKI PHARMACEUTICAL CO (JP)
IINUMA MUNEKAZU (JP)
FURUKAWA SHOEI (JP)
NAIKI MITSURU (JP)
MATSUMOTO TOMONORI (JP)
SUGIMOTO HACHIRO (JP)
International Classes:
C07C219/20; A61K31/16; A61K31/165; A61K31/231; A61K31/255; A61K31/40; A61P25/00; A61P25/02; A61P25/14; A61P25/16; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07C217/08; C07C233/09; C07C233/38; C07C327/30
Domestic Patent References:
WO2003084542A12003-10-16
WO2005032535A12005-04-14
WO2009038110A12009-03-26
Foreign References:
JP2007510634A2007-04-26
US20090124701A12009-05-14
JP2000007568A2000-01-11
JP2003113085A2003-04-18
JP2002080467A2002-03-19
JP2003261545A2003-09-19
JPH07316092A1995-12-05
JP2007217311A2007-08-30
JP2010505893A2010-02-25
Other References:
JOSE M. CONCELLON, ET AL.: "Stereospecific Cyclopropanation of Highly Substituted C-C Double Bonds Promoted by CrCl2. Stereoselective Synthesis of Cyclopropanecarboxamides and Cyclopropyl Ketones", ORGANIC LETTERS, vol. 9, no. 16, 2007, pages 2981 - 2984, XP055069166
ANN. NEUROL., vol. 51, no. 1, January 2002 (2002-01-01), pages 133 - 6
J. NEURAL TRANSM, vol. 112, no. 5, 14 September 2004 (2004-09-14), pages 703 - 11
NEUROPSYCHOPHARMACOLOGY, vol. 28, no. 2, 29 August 2002 (2002-08-29), pages 397 - 401
BR. J. PSYCHIATRY, vol. 189, October 2006 (2006-10-01), pages 317 - 23
PSYCHOPHARMACOLOGY (BERL, vol. 180, no. 1, 26 January 2005 (2005-01-26), pages 95 - 9
J. NEUROSCI., vol. 2'7, no. 16, 18 April 2007 (2007-04-18), pages 4424 - 34
BIOL. PSYCHIATRY, vol. 61, 2007, pages 661 - 670
BASSO DM ET AL., J. NEUROTRAUMA, vol. 12, 1995, pages 1 - 21
CHAPLAN ET AL., JOURNAL OF NEUROSCIENCE METHODS, vol. 53, no. 1, 1994, pages 55 - 63
DIXON ET AL., ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 20, 1980, pages 441 - 462
See also references of EP 2636666A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
Patent business corporation 3 Edakuni [Hajime] patent firm (JP)
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