Title:
TRANSDERMAL ADMINISTRATION OF TAMSULOSIN
Document Type and Number:
WIPO Patent Application WO/2010/083035
Kind Code:
A3
Abstract:
In an aspect of the invention, a composition for making a patch for the transdermal delivery of tamsulosin is provided. The composition comprises (a) at least about 1 wt% tamsulosin or a pharmaceutically acceptable salt of tamsulosin, (b) at least about 40 wt% polyisobutylene adhesive or hydrophobic synthetic rubber adhesive, (c) about 1 -20 wt% of an aprotic solvent in which tamsulosin dissolves readily, (d) about 1-20 wt% of an unsaturated fatty acid or an alpha-hydroxy acid or a mixture of unsaturated fatty acids or alpha-hydroxy acids or of both unsaturated fatty acids and alpha-hydroxy acids, (e) a lipophilic permeation enhancer, and (f) a matrix modifier.
Inventors:
SINGH PARMINDER (US)
LEE EUN SOO (US)
JAIN AMIT K (US)
LEE EUN SOO (US)
JAIN AMIT K (US)
Application Number:
PCT/US2010/000081
Publication Date:
November 04, 2010
Filing Date:
January 14, 2010
Export Citation:
Assignee:
CORIUM INT INC (US)
SINGH PARMINDER (US)
LEE EUN SOO (US)
JAIN AMIT K (US)
SINGH PARMINDER (US)
LEE EUN SOO (US)
JAIN AMIT K (US)
International Classes:
A61K31/137; A61K9/70; A61K31/18; A61K47/06
Domestic Patent References:
| WO2007119656A1 | 2007-10-25 | |||
| WO2001007018A1 | 2001-02-01 | |||
| WO2000061120A1 | 2000-10-19 |
Foreign References:
| US5843472A | 1998-12-01 | |||
| US6602912B2 | 2003-08-05 | |||
| US20060110434A1 | 2006-05-25 | |||
| US5879701A | 1999-03-09 | |||
| US6562369B2 | 2003-05-13 | |||
| US20040220262A1 | 2004-11-04 |
Other References:
See also references of EP 2387394A4
Attorney, Agent or Firm:
ROSE, Flavio, M. et al. (Levin Cohn, Ferris, Glovsky, And Popeo,P.C.,5 Palo Alto Square - 6th Floor,3000 El Camino Rea, Palo Alto CA, US)
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