TRANSDERMAL PATCH - DAINIPPON SUMITOMO PHARMA CO

Title:

TRANSDERMAL PATCH

Document Type and Number:

WIPO Patent Application WO/2012/105624

Kind Code:

A1

Abstract:

The present invention relates to an external-use preparation for transdermal administration which significantly increases skin permeability of 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine (compound A). This adhesive patch is obtained by forming an adhesive layer on one surface of a support body, and is characterized by said adhesive layer containing (i) compound A or a physiologically acceptable acid addition salt thereof, (ii) an adhesive, (iii) lactic acid, and (iv) an additive comprising a specific permeation enhancer. Thereby, the adhesive patch achieves significantly better skin permeability.

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Inventors:

MAEDA HIROO (JP)
YAMAMOTO KAZUMITSU (JP)
TANAKA MASAYASU (JP)

Application Number:

PCT/JP2012/052312

Publication Date:

August 09, 2012

Filing Date:

February 01, 2012

Export Citation:

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Assignee:

DAINIPPON SUMITOMO PHARMA CO (JP)
MAEDA HIROO (JP)
YAMAMOTO KAZUMITSU (JP)
TANAKA MASAYASU (JP)

International Classes:

A61K31/496; A61K9/70; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/22; A61K47/24; A61K47/32; A61K47/34; A61K47/44; A61P25/18; A61P43/00

Domestic Patent References:

WO2007142295A1	2007-12-13
WO2002032431A1	2002-04-25

Foreign References:

JPH07506562A	1995-07-20
JP2003526678A	2003-09-09

Other References: