Title:
TRANSFORMANT CONTAINING PRESENILIN 2 VARIANT GENE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/1998/021315
Kind Code:
A1
Abstract:
Transformation of cells capable of producing or secreting A$g(b)1-42 with a PS-2 variant gene can provide transformed cells which can be subcultured and can produce or secrete a large amount of A$g(b)1-42, and use of the cells enables an A$g(b)1-42 production or secretion inhibitor to be efficiently screened with high sensitivity.
Inventors:
IWATSUBO TAKESHI (JP)
MARUYAMA KEI (JP)
KAKIHANA MITSURU (JP)
MARUYAMA KEI (JP)
KAKIHANA MITSURU (JP)
Application Number:
PCT/JP1997/004079
Publication Date:
May 22, 1998
Filing Date:
November 10, 1997
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
IWATSUBO TAKESHI (JP)
MARUYAMA KEI (JP)
KAKIHANA MITSURU (JP)
IWATSUBO TAKESHI (JP)
MARUYAMA KEI (JP)
KAKIHANA MITSURU (JP)
International Classes:
C07K14/47; (IPC1-7): C12N5/10; C07K14/47; C12N15/12; C12P21/02
Other References:
BIOCHEMISTRY, Vol. 34, (1995), A. ASAMI-ODAKA et al., "Long Amyloid beta-Protein Secreted from Aild-Type Human Neuroblastoma IMR-32", p. 10272-10278.
NEURON, Vol. 19, (1997), DAVID R. BORCHELT et al., "Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins", p. 939-945.
SCIENCE, Vol. 259, (1993), XIAO-DAN CAI et al., "Release of Excess Amyloid beta Protein from a Mutant Amyloid beta Protein Precursor", p. 514-516.
NATURE, Vol. 360, (1992), MARTIN CITRON et al., "Mutation of the beta-Amyloid Precursor Protein in Familial Alzheimer's Disease Increases beta-Protein Production", p. 672-674.
SCIENCE, Vol. 269, (1995), EPHRAT LEVY-LAHAD et al., "A Familial Alzheimer's Disease Locus on Chromosome I", p. 970-973.
NEURON, Vol. 19, (1997), DAVID R. BORCHELT et al., "Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins", p. 939-945.
SCIENCE, Vol. 259, (1993), XIAO-DAN CAI et al., "Release of Excess Amyloid beta Protein from a Mutant Amyloid beta Protein Precursor", p. 514-516.
NATURE, Vol. 360, (1992), MARTIN CITRON et al., "Mutation of the beta-Amyloid Precursor Protein in Familial Alzheimer's Disease Increases beta-Protein Production", p. 672-674.
SCIENCE, Vol. 269, (1995), EPHRAT LEVY-LAHAD et al., "A Familial Alzheimer's Disease Locus on Chromosome I", p. 970-973.
Attorney, Agent or Firm:
Asahina, Tadao (17-85, Jusohonmachi 2-chome, Yodogawa-k, Osaka-shi Osaka 532, JP)
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