Title:
TRANSGENIC ANIMAL FOR LUNG CANCER MODEL, AND PRODUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/099437
Kind Code:
A1
Abstract:
The present invention relates to a lung cancer-inducible transgenic animal and a production method therefor and, more specifically, to: a lung cancer-inducible transgenic animal to which an estrogen antagonist is administered so as to upregulate an EML4-ALK fusion protein; and a production method therefor. Lung cancer can be induced, in the lung cancer-inducible transgenic animal according to the present invention, within a week when an estrogen antagonist is administered only twice, and the induced lung cancer has the same property as that of an EML4-ALK positive lung cancer patient such that conventional various transgenic animals for researching lung cancer can be effectively replaced. In addition, it is expected that the lung cancer-inducible transgenic animal can be applied and used in lung cancer research and in the research of various diseases associated with an EML4-ALK fusion protein.
Inventors:
CHO BYOUNG CHUL (KR)
LEE HAN WOONG (KR)
PYO KYOUNG-HO (KR)
YUN MI RAN (KR)
KIM HYE RYUN (KR)
SUNG YOUNG HOON (KR)
LEE HAN WOONG (KR)
PYO KYOUNG-HO (KR)
YUN MI RAN (KR)
KIM HYE RYUN (KR)
SUNG YOUNG HOON (KR)
Application Number:
PCT/KR2016/014161
Publication Date:
June 15, 2017
Filing Date:
December 05, 2016
Export Citation:
Assignee:
UNIV-INDUSTRY FOUND YONSEI UNIV (KR)
International Classes:
C12N15/85; A01K67/027; C07K14/82; C12N9/10; C12N15/62; C12N15/65; G01N33/50
Foreign References:
| US20130143247A1 | 2013-06-06 | |||
| KR20090092834A | 2009-09-01 | |||
| KR20100096670A | 2010-09-02 |
Other References:
SODA: "A mouse model for EML4-ALK-positive lung cancer", PNAS, vol. 105, no. 50, 2008, pages 19893 - 19897, XP055264459
RAWLINS: "The a ''MAZE'' ing world of lung-specific transgenic mice", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 46, no. 3, 2012, pages 269 - 282, XP055598888, ISBN: 1044-1549, DOI: 10.1165/rcmb.2011-0372PS
PYO: "Establishment of a conditional transgenic mouse model recapitulating EML4-ALK-positive human non-small cell lung cancer", JOURNAL OF THORACIC ONCOLOGY, vol. 12, no. 3, 9 November 2016 (2016-11-09), pages 491 - 500, XP055598893, ISSN: 1556-0864, DOI: 10.1016/j.jtho.2016.10.022
RAWLINS: "The a ''MAZE'' ing world of lung-specific transgenic mice", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, vol. 46, no. 3, 2012, pages 269 - 282, XP055598888, ISBN: 1044-1549, DOI: 10.1165/rcmb.2011-0372PS
PYO: "Establishment of a conditional transgenic mouse model recapitulating EML4-ALK-positive human non-small cell lung cancer", JOURNAL OF THORACIC ONCOLOGY, vol. 12, no. 3, 9 November 2016 (2016-11-09), pages 491 - 500, XP055598893, ISSN: 1556-0864, DOI: 10.1016/j.jtho.2016.10.022
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
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