Title:
TRANSGENIC ANIMAL
Document Type and Number:
WIPO Patent Application WO/2002/011530
Kind Code:
A1
Abstract:
It is intended to a transgenic nonhuman mammal which is usable as a disease model animal for preventives or remedies for chondrogenic failure, osteogenetic failure, osteoporosis, arthritis deformans, rheumatoid arthritis, arthritis, synovitis, metabolic arthritis, eye diseases, malignant tumor and complications thereof and, therefore, makes it possible to clarify the pathological mechanisms of these diseases, examine methods for treating these diseases and screen remedies therefor.
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Inventors:
YOSHIMURA KOJI (JP)
NISHIMURA ATSUSHI (JP)
NISHIDA MAYUMI (JP)
HOSONO KAZUHIRO (JP)
NISHIMURA ATSUSHI (JP)
NISHIDA MAYUMI (JP)
HOSONO KAZUHIRO (JP)
Application Number:
PCT/JP2001/006826
Publication Date:
February 14, 2002
Filing Date:
August 08, 2001
Export Citation:
Assignee:
TAKEDA CHEMICAL INDUSTRIES LTD (JP)
YOSHIMURA KOJI (JP)
NISHIMURA ATSUSHI (JP)
NISHIDA MAYUMI (JP)
HOSONO KAZUHIRO (JP)
YOSHIMURA KOJI (JP)
NISHIMURA ATSUSHI (JP)
NISHIDA MAYUMI (JP)
HOSONO KAZUHIRO (JP)
International Classes:
A01K67/027; A61P19/00; A61P19/02; A61P19/10; A61P27/02; A61P29/00; A61P35/00; C12N9/64; C12N15/85; (IPC1-7): A01K67/027; A61K45/00; A61P19/00; A61P19/02; A61P19/10; A61P27/02; A61P29/00; A61P35/00; C12N5/16; C12N5/18; C12N15/09; G01N33/15; G01N33/50
Domestic Patent References:
| WO1997040157A1 | 1997-10-30 |
Foreign References:
| JPH10309149A | 1998-11-24 |
Other References:
KOHNO ET AL.: "Structure of the promoter of the rat type II procollagen gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 260, no. 7, 1985, pages 4441 - 4447, XP002949721
KREBSBACH ET AL.: "Identification of a minimum enhancer sequence for the type II collagen gene reveals several core sequence motifs in common with the link protein gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 8, 1996, pages 4298 - 4303, XP002949722
MUELLER ET AL.: "Structure of the human MMP-19 gene", GENE, vol. 252, 11 July 2000 (2000-07-11), pages 27 - 37, XP002949723
PENDAS ET AL.: "Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 7, 1997, pages 4281 - 4286, XP002949724
MASSOVA ET AL.: "Matrix metalloproteinases: structures, evolution and diversification", THE FASEB JOURNAL, vol. 12, 1998, pages 1075 - 1095, XP002949725
STRACKE ET AL.: "Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 20, 19 May 2000 (2000-05-19), pages 14809 - 14816, XP002949726
STRACKE ET AL.: "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matric protein (COMP)", FEBS LETTERS, vol. 478, 2 July 2000 (2000-07-02), pages 52 - 56, XP002949727
KOLB ET AL.: "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient", IMMUNOLOGY LETTERS, vol. 57, 1997, pages 83 - 88, XP002949728
KREBSBACH ET AL.: "Identification of a minimum enhancer sequence for the type II collagen gene reveals several core sequence motifs in common with the link protein gene", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 8, 1996, pages 4298 - 4303, XP002949722
MUELLER ET AL.: "Structure of the human MMP-19 gene", GENE, vol. 252, 11 July 2000 (2000-07-11), pages 27 - 37, XP002949723
PENDAS ET AL.: "Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location and tissue distribution", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 7, 1997, pages 4281 - 4286, XP002949724
MASSOVA ET AL.: "Matrix metalloproteinases: structures, evolution and diversification", THE FASEB JOURNAL, vol. 12, 1998, pages 1075 - 1095, XP002949725
STRACKE ET AL.: "Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 20, 19 May 2000 (2000-05-19), pages 14809 - 14816, XP002949726
STRACKE ET AL.: "Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matric protein (COMP)", FEBS LETTERS, vol. 478, 2 July 2000 (2000-07-02), pages 52 - 56, XP002949727
KOLB ET AL.: "The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient", IMMUNOLOGY LETTERS, vol. 57, 1997, pages 83 - 88, XP002949728
Attorney, Agent or Firm:
Kobayashi, Sumiko (Yaesu 2-chome Chuo-ku, Tokyo, JP)
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