Title:
TRANSGENIC NON-HUMAN ANIMAL WITH ATTENUATED PROTEASOME FUNCTION
Document Type and Number:
WIPO Patent Application WO/2023/063400
Kind Code:
A1
Abstract:
Provided is a transgenic non-human animal enabling an analysis of an evaluation of proteasome function and activity on an individual basis. The present invention relates to a transgenic non-human animal and the like with an attenuated proteasome function.
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Inventors:
SAEKI YASUSHI (JP)
TSUCHIYA HIKARU (JP)
YASUDA SAYAKA (JP)
SOMA AI (JP)
SHITARA HIROSHI (JP)
TANAKA KEIJI (JP)
TSUCHIYA HIKARU (JP)
YASUDA SAYAKA (JP)
SOMA AI (JP)
SHITARA HIROSHI (JP)
TANAKA KEIJI (JP)
Application Number:
PCT/JP2022/038287
Publication Date:
April 20, 2023
Filing Date:
October 06, 2022
Export Citation:
Assignee:
TOKYO METROPOLITAN INST MEDICAL SCIENCE (JP)
International Classes:
A01K67/027; A61K45/00; A61P1/00; A61P1/16; A61P13/12; A61P25/00; A61P43/00; C12N15/57; G01N33/15; G01N33/50
Foreign References:
| JP2013039065A | 2013-02-28 | |||
| JP2015513317A | 2015-05-07 |
Other References:
TANAKA KEIJI: "Proteasomes: Elucidation of the principle of operation and physiological pathology", 2018 FISCAL YEAR ANNUAL RESEARCH REPORT, 6 July 2021 (2021-07-06), XP093058972, Retrieved from the Internet [retrieved on 20230629]
SAEKI YASUSHI: "Understand the mechanism of the ubiquitin proteasome system and develop treatment strategies for related diseases!", LABORATORIES, DEPARTMENT OF MEDICAL INFORMATICS AND LIFE SCIENCES, GRADUATE SCHOOL OF FRONTIER SCIENCES, UNIV. OF TOKYO, 1 April 2021 (2021-04-01), XP093058973, Retrieved from the Internet [retrieved on 20230629]
SéBASTIEN KüRY, THOMAS BESNARD, FRéDéRIC EBSTEIN, TAHIR N. KHAN, TOMASZ GAMBIN, JESSICA DOUGLAS, CARLOS A. BAC: "De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder", THE AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS , CHICAGO , IL, US, vol. 100, no. 2, 1 February 2017 (2017-02-01), US , pages 352 - 363, XP055482689, ISSN: 0002-9297, DOI: 10.1016/j.ajhg.2017.01.003
YAMAMOTO, MIYUKI AND 6 OTHERS: "Morphological study of the submandibular gland in mice with reduced proteasome activity", ACTA ANATOMICA NIPPONICA, vol. 85, 2010, pages 142, ISSN: 0022-7722
SAEKI YASUSHI: "Understand the mechanism of the ubiquitin proteasome system and develop treatment strategies for related diseases!", LABORATORIES, DEPARTMENT OF MEDICAL INFORMATICS AND LIFE SCIENCES, GRADUATE SCHOOL OF FRONTIER SCIENCES, UNIV. OF TOKYO, 1 April 2021 (2021-04-01), XP093058973, Retrieved from the Internet
SéBASTIEN KüRY, THOMAS BESNARD, FRéDéRIC EBSTEIN, TAHIR N. KHAN, TOMASZ GAMBIN, JESSICA DOUGLAS, CARLOS A. BAC: "De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder", THE AMERICAN JOURNAL OF HUMAN GENETICS, AMERICAN SOCIETY OF HUMAN GENETICS , CHICAGO , IL, US, vol. 100, no. 2, 1 February 2017 (2017-02-01), US , pages 352 - 363, XP055482689, ISSN: 0002-9297, DOI: 10.1016/j.ajhg.2017.01.003
YAMAMOTO, MIYUKI AND 6 OTHERS: "Morphological study of the submandibular gland in mice with reduced proteasome activity", ACTA ANATOMICA NIPPONICA, vol. 85, 2010, pages 142, ISSN: 0022-7722
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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