TRANSGLUTAMINASE CROSSLINKED COLLAGEN BIOMATERIAL FOR MEDICAL IMPLANT MATERIALS

WIPO Patent Application WO2006027622

A3

The present invention provides a method for producing an improved biomaterial comprising treating a collagen biomaterial with a transglutaminase under conditions which permit the formation of cross-links within the collagen. Preferably, the transglutaminase is a tissue transglutaminase, a plasma transglutaminase or a microbial transglutaminase. In a preferred embodiment, the collagen biomaterial further comprises a cell adhesion factor, such as fibronectin. The invention further provides biomaterials obtainable by the methods of the invention, and medical implants and wound dressings comprising the same.

GRIFFIN MARTIN (GB)
COLLIGHAN RUSSELL (GB)
CHAU DAVID (GB)
VERDERIO EDWARDS ELISABETTA (GB)

PCT/GB2005/003520

November 23, 2006

September 12, 2005

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UNIV ASTON (GB)
GRIFFIN MARTIN (GB)
COLLIGHAN RUSSELL (GB)
CHAU DAVID (GB)
VERDERIO EDWARDS ELISABETTA (GB)

A61L27/60; A61F2/10; A61L15/32; A61L27/24; A61L27/38; C12N5/00

WO1997040701A1

1997-11-06

ERWANTO Y ET AL: "EFFECT OF HEATING ON POLYMERIZATION OF PIG SKIN COLLAGEN USING MICROBIAL TRANSGLUTAMINASE", ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, SUWEON, KR, vol. 15, no. 8, 2002, pages 1204 - 1209, XP001182377, ISSN: 1011-2367
ORBAN JANINE M ET AL: "Crosslinking of collagen gels by transglutaminase", J. BIOMED. MATER. RES. PART A; JOURNAL OF BIOMEDICAL MATERIALS RESEARCH - PART A MAR 15 2004, vol. 68, no. 4, 15 March 2004 (2004-03-15), pages 756 - 762, XP002391635

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